Nutrient intake in women with primary and secondary Sjögren's syndrome

Cermák, J; Papas, Athena; Sullivan, Rose M.; Dana, M. Reza; Sullivan, D. A.

doi:10.1038/sj.ejcn.1601543

Cited by 34 publications

(25 citation statements)

References 34 publications

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“…The low dietary intake of vitamin B 6 was determined to be the result of a reduced consumption of foods rich in this vitamin such as grains and cereals. A more recent study also reported several nutritional deficiencies in this type of patients (Cermak et al, 2003).…”

Section: Introductionsupporting

confidence: 56%

Detection and recognition thresholds to the 4 basic tastes in Mexican patients with primary Sjögren's syndrome

et al. 2004

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Background: Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease characterized by inflammatory lymphocytic infiltration of the salivary glands, leading to dryness of the mouth (xerostomia). It has been postulated that xerostomia is the preceding stage for the development of alterations in taste acuity (dysgeusia) in this type of patients. Objectives: To determine detection and recognition thresholds to the 4 basic tastes (sweet, salty, sour and bitter) in pSS patients and compare them to a control group. To determine if the long-term consumption of chile peppers and spicy Mexican diets had an effect on the taste perception and acuity of the pSS patients. Interventions: Detection and recognition thresholds were determined by the method of least noticeable differences on three occasions during three nonconsecutive days. Saliva production was determined by Saxon's test on two separate occasions. Results: Although saliva production was severely reduced in pSS patients (1.3570.55 ml/2 min, Po0.001) compared to controls (6.2672.41 ml/2 min), all subjects recognized the 4 basic tastes when these were tested at suprathreshold concentrations. The detection thresholds for the sweet, sour and bitter tastes were higher in pSS patients, as well as the recognition thresholds for the salty, sour and bitter tastes. A relationship between time of evolution of the disease and saliva production with individual thresholds could not be established. Conclusions: pSS patients exhibited different degrees of dysgeusia depending on the taste being studied, that is, they were mildly dysgeusic for the sweet and salty tastes and clearly dysgeusic for the sour and bitter tastes. Although both pSS patients and controls had consumed 'typical Mexican diets' their entire lives, our results showed that the consumption of chile peppers and spicy foods did not have any effect on the taste perception and acuity of the pSS patients.

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Section: Introductionsupporting

confidence: 56%

Detection and recognition thresholds to the 4 basic tastes in Mexican patients with primary Sjögren's syndrome

et al. 2004

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“…Furthermore, it has been proposed that dietary factors may contribute to the etiology and progression SLE and SjS syndrome, and that nutritional intervention may modify the severity of pathological abnormalities (Lefkowith and Klahr, 1996;Simopoulos, 2002;Cermak et al, 2003;Pestka, 2010). A previous report indicates that n−3 PUFA-supplemented diet has positive effects on autoimmune-prone NZB/W female mice by regulating the activity of antioxidant enzymes (Bhattacharya et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

n−3 fatty acids prevent impairment of neurogenesis and synaptic plasticity in B-cell activating factor (BAFF) transgenic mice

Crupi

Cambiaghi

Deckelbaum

et al. 2012

Preventive Medicine

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Objective. Autoimmune-prone B-cell activating factor transgenic mice, a mouse model of systemic lupus erythematosus and Sjögren's syndrome exhibit neuroinflammation, anxiety-like phenotype, deficit in adult hippocampal neurogenesis and impaired neurogenesis-dependent and neurogenesis-independent dentate gyrus long-term potentiation. Given that n−3 polyunsaturated fatty acids regulate hippocampal plasticity and inflammatory responses, we investigated whether n−3 polyunsaturated fatty acids-enriched diet might prevent age-dependent hippocampal changes in B-cell activating factor transgenic mice.Methods. B-cell activating factor transgenic mice were fed for 12 weeks with either n−3 polyunsaturated fatty acids-enriched or control diet and we tested the effect of this dietary supplementation on hippocampal inflammation, progenitor cell proliferation and neurogenesis-dependent and neurogenesis-independent long-term potentiation.Results. Dietary supplementation with n−-3 polyunsaturated fatty acids significantly decreased hippocampal microglial activation and increased the density of bromodeoxyuridine and doublecortin-positive newly-formed cells in the subventricular zone of hippocampus. Furthermore, B-cell activating factor transgenic mice fed with n-3 polyunsaturated fatty acids-enriched diet displayed normal long-term potentiation at the medial perforant pathway/dentate gyrus connections.Conclusions. The results indicate that n-3 fatty acids prevent neuroinflammation and deficits of hippocampal plasticity in B-cell activating factor transgenic mice and suggest that increased n-3 fatty acids intake might represent a potential therapeutic option to prevent neuropsychiatric symptoms associated with autoimmune diseases.

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“…The study of Cermak et al [7] showed that the diet of patients suffering from dry eye was poorer in EPA and DHA than that of control patients. Moreover, a low dietary n-3/n-6 ratio was positively correlated with a systemic injury and clinical manifestations of exocrine tissue in Gougerot-Sjögren syndrome [9].…”

Section: Introductionmentioning

confidence: 98%

“…DHA is the precursor of neuroprotectin D1 that plays key roles in controlling inflammation [6]. The potential benefits of n-3 PUFAs have been tested in epidemiological studies suggesting the negative impact of a diet containing low amounts of n-3 PUFAs with a high n-6/n-3 ratio [7][8][9]. In particular, the Women's Health Study, conducted on almost 40,000 female health professionals, has shown that high n-3 PUFA intake was inversely associated with the prevalence of dry eye and a high dietary n-6/n-3 ratio with an increased risk of dry eye [8].…”

Section: Introductionmentioning

confidence: 99%

No consequences of dietary n-3 polyunsaturated fatty acid deficiency on the severity of scopolamine-induced dry eye

Viau

Pasquis

Maire

et al. 2010

Graefes Arch Clin Exp Ophthalmol

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Nutrient intake in women with primary and secondary Sjögren's syndrome

Cited by 34 publications

References 34 publications

Detection and recognition thresholds to the 4 basic tastes in Mexican patients with primary Sjögren's syndrome

Detection and recognition thresholds to the 4 basic tastes in Mexican patients with primary Sjögren's syndrome

n−3 fatty acids prevent impairment of neurogenesis and synaptic plasticity in B-cell activating factor (BAFF) transgenic mice

No consequences of dietary n-3 polyunsaturated fatty acid deficiency on the severity of scopolamine-induced dry eye

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