Malnutrition in long‐term haemodialysis survivors

Chazot, Charles; Laurent, Guy; Charra, Bernard; Blanc, Corinne; Vo-Van, Cyril; Gadrey, Jean; Vanel, Thiery; Terrat, Jean Claude; Ruffet, Martial

doi:10.1093/ndt/16.1.61

Cited by 77 publications

(38 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A large proportion of patients on maintenance hemodialysis (HD) have PEM, and this condition is strongly associated with increased morbidity and mortality. [1][2][3] Reduced protein energy intake, adverse dialysis-related events, chronic inflammation, and concomitant acute and chronic illness are the main factors responsible for malnutrition in HD patients. [4][5][6][7][8][9][10] Obesity has been identified as an independent risk factor for cardiovascular disease in the general population.…”

Section: Introductionmentioning

confidence: 99%

Increased Body Mass Index Is Not a Reliable Marker of Good Nutrition in Hemodialysis Patients

et al. 2007

View full text Add to dashboard Cite

Objective. The aim of the study was to assess the body fat (BF) composition in hemodialysis (HD) patients using anthropometry and bioelectrical impedance analysis (BIA) and investigate relationships between BIA-determined BF composition and nutritional parameters in different weight groupings. Design. Cross-sectional study. Setting. A tertiary-care university hospital. Methods. 164 HD patients (M/F: 89/75, mean age: 48.4 ± 15.8 years, mean HD duration: 58.2 ± 42.6 months) were divided into three groups according to body mass index (BMI): normal weight (NW: BMI 18.5-24.9), overweight (OW: BMI 25-29.9), obese (OB, BMI ≥ 30). Biochemical parameters and BF composition using anthropometry and foot-to-foot BIA were compared between three groups. Results. Ninety-six (59%) patients were NW, 40 (24%) were OW, and 28 (17%) were OB. Average mean skinfold thickness (p = 0.005), mid-arm circumference (p = 0.001), BF% (p = 0.001), and fat-free mass (FFM) (p = 0.03) were all significantly greater in the OB group than in the NW group. Compared to the NW patients, the OB group had significantly higher serum levels of glucose (p = 0.03), total cholesterol (p = 0.02), and triglycerides (p = 0.02), but significantly lower serum albumin (p = 0.05) and blood urea nitrogen (p = 0.05). The OB group also had significantly higher white blood cell count (p=0.002) and serum CRP (p = 0.001) than the NW group. Conclusions. The results suggest that BIA-determined BF composition is correlated with body mass index. In addition, obesity is associated with elevated CRP and white blood cell count and lower serum albumin level in HD patients.

show abstract

Section: Introductionmentioning

confidence: 99%

Increased Body Mass Index Is Not a Reliable Marker of Good Nutrition in Hemodialysis Patients

et al. 2007

View full text Add to dashboard Cite

show abstract

“…Согласно литературным данным, улучшение параметров питания способствует снижению за-болеваемости и смертности в данной популяции [62,63]. Результаты ряда исследований, в том чис-ле рандомизированных, свидетельствуют о лучшем статусе питания у пациентов, получающих высоко-объемную ГДФ по сравнению с СТГД.…”

Section: улучшение статуса питанияunclassified

Online Hemodiafiltration: Clinical Results and Economic Evaluation

Поз¹,

Строков²,

Копылова³

2014

Russian Journal of Transplantology and Artificial Organs

View full text Add to dashboard Cite

Безопасность ОЛ-ГДФ целиком основывает-ся на строгом и постоянном соблюдении правил проведения процедуры и обслуживания оборудо-вания. В настоящее время около 15% диализных пациентов Западной Европы получают ОЛ-ГДФ, в России эту методику практикует треть центров ге-модиализа (ГД). Ограничивающим фактором для более широкого применения этого метода явля-ются законодательно-административные барьеры на использование приготавливаемой онлайн заме-щающей жидкости [1]. Главный принцип онлайн-приготовления замещающего раствора -постоян-ная стерилизация с помощью ультрафильтрации (УФ) и непосредственное использование -не рассматривается Фармакопеей в качестве стери-лизационного метода. Изготовление лекарства (замещающий раствор) с помощью аппарата (из диализирующей жидкости) с использованием дру-гого устройства (ультрафильтр) -процесс, выхо- Вторая часть обзора посвящена правовым и финансовым аспектам онлайн-гемодиафильтрации, а также ее влиянию на непосредственные и отдаленные результаты лечения. Недавно завершенные рандомизи-рованные исследования подтвердили, что высокообъемная онлайн-гемодиафильтрация позволяет улуч-шить выживаемость пациентов. Эти данные должны переломить инерцию, препятствующую повсемес-тному внедрению онлайн-гемодиафильтрации в качестве основной методики в практику программного гемодиализа.Ключевые слова: онлайн-гемодиафильтрация, регулирование, клиническая эффективность. Second part of review summarizes legal and fi nancial aspects of online hemodiafi ltration and its infl uence on short-term and long-term treatment results. According to recently completed randomized clinical trials, high volume online hemodiafi ltration is able to improve patients' survival rate. The results mentioned in the review must overpower the inertia which obstructs a wide implementation of online hemodiafi ltration into routine clinical practice. ONLINE HEMODIAFILTRATION: CLINICAL RESULTS AND ECONOMIC EVALUATION

show abstract

“…Lower BMI in ESRD is a predictable consequence of the malnutrition found in this disease state. 17 Within the control group (n ϭ 150), there were 76 hypertensive and 74 normotensive individuals. Compared with the normotensives, the hypertensives had higher blood pressure (BP) (systolic BP/diastolic BP, P Ͻ 0.0001/P Ͻ 0.0001) were older (53 Ϯ 1.1 versus 43 Ϯ 0.8 yr, P Ͻ 0.0001) and more likely to have diabetes (28.4% versus 2.7%, P Ͻ 0.0001) and a positive family history of hypertension (74.7% versus 58.1%, P ϭ 0.014).…”

Section: Study Subjectsmentioning

confidence: 99%

Chromogranin A Polymorphisms Are Associated With Hypertensive Renal Disease

Salem

Cadman²,

Chen³

et al. 2008

Journal of the American Society of Nephrology

View full text Add to dashboard Cite

Chromogranin A is released together with epinephrine and norepinephrine from catecholaminergic cells. Specific endopeptidases cleave chromogranin A into biologically active peptide fragments, including catestatin, which inhibits catecholamine release. Previous studies have suggested that a deficit in this sympathetic "braking" system might be an early event in the pathogenesis of human hypertension. Whether chromogranin A (CHGA) polymorphisms predict end-organ complications of hypertension, such as end-stage renal disease, is unknown. Among blacks, we studied common genetic variants spanning the CHGA locus in 2 independent case-control studies of hypertensive ESRD. Two haplotypes were significantly more frequent among subjects with hypertensive ESRD: 1) in the promoter (5Ј) region, G-462A3T-415C3C-89A, haplotype ATC (adjusted odds ratio ϭ 2.65; P ϭ 0.037), and 2) at the 3Ј-end, C11825T (3Ј-UTR, Cϩ87T)3G12602C, haplotype TC (adjusted odds ratio ϭ 2.73, P ϭ 0.0196). Circulating levels of catestatin were lower among those with hypertensive ESRD than controls, an unexpected finding given that peptide levels are usually elevated in ESRD because of reduced renal elimination. We found that the 3Ј-UTR ϩ 87T variant decreased reporter gene expression, providing a possible mechanistic explanation for diminished catestatin. In summary, common variants in chromogranin A associate with the risk of hypertensive ESRD in blacks.

show abstract

Malnutrition in long‐term haemodialysis survivors

Cited by 77 publications

References 26 publications

Increased Body Mass Index Is Not a Reliable Marker of Good Nutrition in Hemodialysis Patients

Increased Body Mass Index Is Not a Reliable Marker of Good Nutrition in Hemodialysis Patients

Online Hemodiafiltration: Clinical Results and Economic Evaluation

Chromogranin A Polymorphisms Are Associated With Hypertensive Renal Disease

Contact Info

Product

Resources

About