Malnutrition and inflammation in peritoneal dialysis patients

Fein, Paul A.; Mittman, Neal; Gadh, Rajdeep; Chattopadhyay, Jyotiprakas; Blaustein, Daniel A.; Mushnick, Robert; Avram, Morrell M.

doi:10.1046/j.1523-1755.64.s87.13.x

Cited by 30 publications

(33 citation statements)

References 31 publications

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“…Patients with lower serum magnesium had a significantly greater age and serum albumin was lower, compared with those with higher serum magnesium. These results are in accordance with others [17,41] and may indicate that lower magnesium is related to malnutrition in these patients.…”

Section: Discussionsupporting

confidence: 94%

Lower Serum Magnesium Is Associated with Cardiovascular Risk Factors and Mortality in Haemodialysis Patients

et al. 2014

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Background: Hypomagnesaemia is a cardiovascular (CV) risk factor in the general population. The aim of this study was to evaluate the relationship between pre-dialysis magnesium (Mg) and CV risk markers, [including pulse pressure (PP), left ventricular mass index (LVMI) and vascular calcifications (VC)], and mortality in haemodialysis (HD) patients. Methods: We performed a 48-month prospective study in 206 patients under pre-dilution haemodiafiltration with a dialysate Mg concentration of 1 mmol/l. Results: Lower Mg concentrations were predictors of an increased PP (≥65 mm Hg) (p = 0.002) and LVMI (≥140 g/m2) (p = 0.03) and of a higher VC score (≥3) (p = 0.01). Patients with Mg <1.15 mmol/l had a lower survival at the end of the study (p = 0.01). Serum Mg <1.15 mmol/l was an independent predictor of all-cause (p = 0.01) and CV mortality (p = 0.02) when adjusted for multiple CV risk factors. Conclusions: Lower Mg levels seem to be associated with increased CV risk markers, like PP, LVMI and VC, and with higher mortality in HD patients.

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Section: Discussionsupporting

confidence: 94%

Lower Serum Magnesium Is Associated with Cardiovascular Risk Factors and Mortality in Haemodialysis Patients

et al. 2014

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“…It is also related to cognitive and neuropsychiatric deficits in some neurodegenerative disorders [27]. Lower levels of serum albumin, pre-albumin, and creatinine were well established as being associated with increased mortality in dialysis patients [28]. However, the present investigation showed no significant difference at albumin, dry weight, BMI, TSF, AMA values, and creatinine levels between nondementia and dementia patients.…”

Section: Discussioncontrasting

confidence: 57%

Alterations in Trace Elements and Oxidative Stress in Uremic Patients with Dementia

Guo¹,

Ko²,

Chen³

et al. 2009

Biol Trace Elem Res

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The present study was conducted to compare the trace elements and oxidative status between uremic patients with and without dementia. Chronic hemodialysis patients with dementia (n = 20) and without dementia (n = 25), and age-matched healthy volunteers (n = 20) were enrolled. The nutritional status, blood levels of trace elements aluminum (Al), zinc (Zn), copper (Cu), magnesium (Mg) and iron (Fe), malondialdehyde (MDA), and protein carbonyl production, antioxidant enzymes glutathione peroxidase (GPx), and glutathione reductase (GR) activities were measured. No significant difference in nutritional status or clinical characteristics was observed between nondementia and dementia patients. However, uremic patients with dementia have significantly higher Al, Cu, and Mg and lower Zn concentrations, as well as increased Cu/Zn ratio in comparison to nondementia patients. There were statistically significant increased MDA and carbonyl production and decreased GPx and GR activities in dementia patients. Furthermore, the significant associations of Al, Mg, and Cu/Zn ratio with oxidative status in patients with dementia were noted. The dementia may initially worsen with abnormal metabolism of trace elements and oxidative stress occurrence. Our results suggest that abnormalities in trace element levels are associated with oxidative stress and may be a major risk factor in the dementia development of uremic patients.

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“…Similar findings have been suggested by Fein et al. (22) who showed that DM patients had a higher CRP than non‐DM patients on PD. Ducloux et al.…”

Section: Discussionsupporting

confidence: 89%

“…In the present study, the level of the cubic root of hs-CRP was significantly higher in the DM patient group over time. Similar findings have been suggested by Fein et al (22) who showed that DM patients had a higher CRP than non-DM patients on PD. Ducloux et al (23) suggested that the level of CRP, a general cardiovascular marker in patients on dialysis, was associated with an increased incidence of cardiovascular disease in PD patients.…”

Section: The Effect Of Pd In Diabetic Patients 481supporting

confidence: 90%

Difficulty in Improving Malnutrition and Low‐grade Inflammation in Diabetic Patients on Peritoneal Dialysis

et al. 2008

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Continuous ambulatory peritoneal dialysis (CAPD) is commonly used for renal replacement therapy in diabetes mellitus (DM) patients. We investigated the changes of peritoneal transport characteristics, nutritional status, and adequacy and inflammation parameters in diabetic CAPD patients (N = 17) compared to non-diabetic patients (N = 23). Peritoneal equilibrium testing, nutritional, biochemical, and anthropometric parameters and adequacy were prospectively assessed at 1 (baseline), 6 and 12 months after initiating CAPD. The levels of several nutritional parameters were lower and did not change in DM patients over time (P < 0.05) and significantly improved in the non-DM patients over time (P < 0.05). Total weekly creatinine clearance and residual renal function exhibited a rapid decline (P < 0.05) and inflammation parameter levels were higher in DM patients (P < 0.05). Our results showed the difficulty in improvement of nutritional status and inflammatory parameters in diabetic patients during at least the first year of CAPD compared to non-DM patients.

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Malnutrition and inflammation in peritoneal dialysis patients

Cited by 30 publications

References 31 publications

Lower Serum Magnesium Is Associated with Cardiovascular Risk Factors and Mortality in Haemodialysis Patients

Lower Serum Magnesium Is Associated with Cardiovascular Risk Factors and Mortality in Haemodialysis Patients

Alterations in Trace Elements and Oxidative Stress in Uremic Patients with Dementia

Difficulty in Improving Malnutrition and Low‐grade Inflammation in Diabetic Patients on Peritoneal Dialysis

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