Alterations in Trace Elements and Oxidative Stress in Uremic Patients with Dementia

Guo, Chih-Hung; Ko, Wang‐Sheng; Chen, Pei-Chung; Hsu, Guoo-Shyng Wang; Lin, Chia-Yeh; Wang, Chia-Liang

doi:10.1007/s12011-009-8342-9

Cited by 19 publications

(11 citation statements)

References 43 publications

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“…Carbonyls were increased already at severe stage of CKD and its production was intensifying in both HD and PD patients. Our results were in agreement with previous findings which associated the increased levels of lipid peroxidation with the severity of coronary atherosclerosis in patients with CKD [23]. …”

Section: Discussionsupporting

confidence: 94%

Effect of Different Stages of Chronic Kidney Disease and Renal Replacement Therapies on Oxidant-Antioxidant Balance in Uremic Patients

Tbahriti

Kaddous

Bouchenak

et al. 2013

Biochemistry Research International

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Oxidative stress seems to be involved in the path physiology of cardiovascular complications of chronic kidney disease (CKD). In this study, we determined the effect of different stages of CKD and substitutive therapies on oxidative stress. One hundred sixty-seven patients (age: 44 ± 06 years; male/female: 76/91) with CKD were divided into 6 groups according to the National Kidney Foundation classification. Prooxidant status was assessed by assaying thiobarbituric acid reactive substances, hydroperoxides, and protein carbonyls. Antioxidant defence was performed by analysis of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, vitamin E, Iron, and bilirubin. TBARS and LPO were higher in HD patients compared to other groups (P < 0.001), while protein carbonyls were more increased in PD patients. The antioxidant enzymes were declined already at severe stage of CKD and they were declined notably in HD patients (P < 0.001). Similar observation was found for vitamin E, Fe, and bilirubin where we observed a significant decrease in the majority of study groups, especially in HD patients (P < 0.001). The evolution of CKD was associated with elevated OS. HD accentuates lipid, while PD aggravates protein oxidation. However, the activity of antioxidant enzymes was altered by impaired renal function and by both dialysis treatments.

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Section: Discussionsupporting

confidence: 94%

Effect of Different Stages of Chronic Kidney Disease and Renal Replacement Therapies on Oxidant-Antioxidant Balance in Uremic Patients

Tbahriti

Kaddous

Bouchenak

et al. 2013

Biochemistry Research International

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“…Their negative effect on SI, sperm quality, and quantity may be explained by the effect of 200 mg/l dose, disturbing testosterone homeostasis, but two other mechanisms may also play a role. Guo and colleagues [69]suggested that aluminum induces production of nitrogen monoxide (NO), a suppressor of circulating and testicular testosterone. Alternatively, Zhu and collaborators [70] suggested that the main reason for reduced spermatogenesis in male rats was a decline in testicular enzyme activity and an imbalance in the concentrations of other trace elements (Zn, Fe, Cu) in the testes.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Aluminum Exposure on Reproductive Ability in the Bank Vole (Myodes glareolus)

Miska-Schramm

Kapusta

Kruczek

2016

Biol Trace Elem Res

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Human impact on the environment is steadily increasing the amounts of aluminum in the ecosystems. This element accumulates in plants and water, potentially exposing herbivores to its harmful effect. In heavily polluted sites, a decrease in the density of small rodent populations has been observed. This decline may be caused by many factors, including decreased fertility. The aim of the presented research was to determine how aluminum, administered at concentrations similar to those recorded in industrial districts (Al I = 3 mg/l, Al II = 200 mg/l), affects the reproductive abilities of small rodents. As the indicators of reproductive abilities, body weight, weight of the testes and accessory sex glands of males, and uterus weight of females were estimated. In females, the number of matured follicles (types 6, 7, and 8) was analyzed, while in males, the quantity and quality (matured, viable, swollen, motile, head abnormalities) of epididymal sperm cells were assessed. Moreover, the development of testes, measured by spermatogenic index, was determined. The model species was the bank vole. Our results have proven that aluminum impairs adult individuals’ reproductive abilities by decreasing the quality and quantity of sperm cells and by causing morphologically abnormal development of the gonads. However, no difference in male organometric parameters was found, and only in females treated with 3 mg/l Al, the uterus weight was higher than control. No differences were found in the total number of matured follicles. These results suggest that the decline in rodent numbers in industrial districts is due, at least in part, to poorer males’ reproductive abilities, resulting from exposure to aluminum contamination.

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“…Oxidative stress results from changes in the levels of trace elements. It has been reported that increased Mg level is associated with the increased production of MDA in dementia patients [ 58 ]. Our result also showed an increasing pattern of Mg concentration along with increase in liver TBARS level.…”

Section: Discussionmentioning

confidence: 99%

In VivoEffect of Arsenic Trioxide on Keap1-p62-Nrf2 Signaling Pathway in Mouse Liver: Expression of Antioxidant Responsive Element-Driven Genes Related to Glutathione Metabolism

et al. 2013

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Arsenic is a Group I human carcinogen, and chronic arsenic exposure through drinking water is a major threat to human population. Liver is one of the major organs for the detoxification of arsenic. The present study was carried out in mice in vivo after arsenic treatment through drinking water at different doses and time of exposure. Arsenic toxicity is found to be mediated by reactive oxygen species. Nuclear factor (erythroid-2 related) factor 2 (Nrf2)/Keap1 (Kelch-like ECH-associated protein 1)/ARE (antioxidant response element)—driven target gene system protects cells against oxidative stress and maintains cellular oxidative homeostasis. Our result showed 0.4 ppm, 2 ppm, and 4 ppm arsenic trioxide treatment through drinking water for 30 days and 90 days induced damages in the liver of Swiss albino mice as evidenced by histopathology, disturbances in liver function, induction of heat shock protein 70, modulation of trace elements, alteration in reduced glutathione level, glutathione-s-transferase and catalase activity, malondialdehyde production, and induction of apoptosis. Cellular Nrf2 protein level and mRNA level increased in all treatment groups. Keap1 protein as well as mRNA level decreased concomitantly in arsenic treated mice. Our study clearly indicates the important role of Nrf2 in activating ARE driven genes related to GSH metabolic pathway and also the adaptive response mechanisms in arsenic induced hepatotoxicity.

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Alterations in Trace Elements and Oxidative Stress in Uremic Patients with Dementia

Cited by 19 publications

References 43 publications

Effect of Different Stages of Chronic Kidney Disease and Renal Replacement Therapies on Oxidant-Antioxidant Balance in Uremic Patients

Effect of Different Stages of Chronic Kidney Disease and Renal Replacement Therapies on Oxidant-Antioxidant Balance in Uremic Patients

The Effect of Aluminum Exposure on Reproductive Ability in the Bank Vole (Myodes glareolus)

In VivoEffect of Arsenic Trioxide on Keap1-p62-Nrf2 Signaling Pathway in Mouse Liver: Expression of Antioxidant Responsive Element-Driven Genes Related to Glutathione Metabolism

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