Effect of Different Stages of Chronic Kidney Disease and Renal Replacement Therapies on Oxidant-Antioxidant Balance in Uremic Patients

Tbahriti, Hadja Fatima; Kaddous, A.; Bouchenak, Malika; Mekki, Khedidja

doi:10.1155/2013/358985

Cited by 73 publications

(65 citation statements)

References 35 publications

(36 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, the potentiation of this antioxidant pathway could be a promising strategy to prevent uremia-induced endothelial dysfunction. In fact, a decrease in plasma levels of GSH or GPx have been shown in CKD patients [9,[45][46][47], and a decreased GSH/GSSG ratio in ECs exposed to uremic media have been previously reported [35]. This later finding is in contrast to our results, since a slight increase in GSH in uremic endothelial cells has been observed, which could be a compensatory response against the prooxidant state present in endothelial cells in response to the uremic milieu.…”

Section: Discussioncontrasting

confidence: 89%

Antioxidant and Anti-Inflammatory Strategies Based on the Potentiation of Glutathione Peroxidase Activity Prevent Endothelial Dysfunction in Chronic Kidney Disease

Vera

Torramadé-Moix

Martin-Rodriguez

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Accelerated atherosclerosis in chronic kidney disease (CKD) is preceded by endothelial dysfunction (ED), which exhibits a proinflammatory and prothrombotic phenotype and enhanced oxidative stress. In this study, the effect of several compounds with anti-inflammatory and/or antioxidant properties on uremia-induced endothelial dysfunction has been evaluated in an in vitro model. Methods: Endothelial cells (ECs) were exposed to sera from uremic patients in the absence and presence of the flavonoids apigenin, genistein and quercetin, the antioxidant enzyme mimetics (AEM) ebselen (glutathione peroxidase mimetic), EUK-134 and EUK-118 (both superoxide dismutase mimetics), and the pharmacological drug N-acetylcysteine (NAC). We explored changes in the expression of adhesion receptors on the cell surface, by immunofluorescence, the production of radical oxygen species (ROS), by fluorescence detection, and the activation of signaling proteins related to inflammation, by both a phosphospecific antibody cell-based ELISA and immunoblotting techniques. Results: Uremic media induced a significantly increased expression of ICAM-1, overproduction of radical oxygen species (ROS) and activation of p38 mitogen activated protein kinase (p38MAPK) and Nuclear Factor kB (NFkB) in ECs. Quercetin, the AEM and NAC showed a significant inhibitory effect on both ICAM-1 expression and ROS generation (p<0.05). All the compounds reduced p38MAPK activation, but only the AEM, especially ebselen, and NAC, both potentiating the glutathione peroxidase pathway, also inhibited NFkB activation. These two compounds were capable of increasing endothelial glutathione levels, especially in response to uremia. Conclusion: Our results indicate that the potentiation of the antioxidant pathways can be an effective strategy to improve endothelial dysfunction in uremia and a potential target to reduce the cardiovascular risk in this population.

show abstract

Section: Discussioncontrasting

confidence: 89%

Antioxidant and Anti-Inflammatory Strategies Based on the Potentiation of Glutathione Peroxidase Activity Prevent Endothelial Dysfunction in Chronic Kidney Disease

Vera

Torramadé-Moix

Martin-Rodriguez

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…21 In contrast, CRF quantifies the overall corneal viscoelastic resistance to indentation. 18 Patients with chronic renal disease have high levels of oxidative stress, 22 and oxidative stress has been shown to affect collagen synthesis and extracellular matrix compounds. [23][24][25] Uremic toxins may disrupt the balance between proapoptotic and antiapoptotic factors as well as between preinflammatory and anti-inflammatory factors.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Intraocular Pressure by Ocular Response Analyzer in Patients Undergoing Hemodialysis

Yüksel

Duru

et al. 2016

Journal of Glaucoma

View full text Add to dashboard Cite

show abstract

“…The level of TBARS and lipid hydroperoxides and protein carbonyls increased with stage of chronic kidney disease in another study, and there was an inverse change in activity of superoxide dismutase, catalase, glutathione reductase, glutathione peroxidase and levels of vitamin E [74]. …”

Section: Chronic Diseases Associated With Oxidative Stressmentioning

confidence: 99%

Role of Tyrosine Isomers in Acute and Chronic Diseases Leading to Oxidative Stress - A Review

Molnár¹,

Kun²,

Sélley³

et al. 2016

CMC

View full text Add to dashboard Cite

Oxidative stress plays a major role in the pathogenesis of a variety of acute and chronic diseases. Measurement of the oxidative stress-related end products may be performed, e.g. that of structural isomers of the physiological para-tyrosine, namely meta- and ortho-tyrosine, that are oxidized derivatives of phenylalanine. Recent data suggest that in sepsis, serum level of meta-tyrosine increases, which peaks on the 2nd and 3rd days (p<0.05 vs. controls), and the kinetics follows the intensity of the systemic inflammation correlating with serum procalcitonin levels. In a similar study subset, urinary meta-tyrosine excretion correlated with both need of daily insulin dose and the insulin-glucose product in non-diabetic septic cases (p<0.01 for both). Using linear regression model, meta-tyrosine excretion, urinary meta-tyrosine/para-tyrosine, urinary ortho-tyrosine/para-tyrosine and urinary (meta- + ortho-tyrosine)/para-tyrosine proved to be markers of carbohydrate homeostasis.In a chronic rodent model, we tried to compensate the abnormal tyrosine isomers using para-tyrosine, the physiological amino acid. Rats were fed a standard high cholesterol-diet, and were given para-tyrosine or vehicle orally. High-cholesterol feeding lead to a significant increase in aortic wall meta-tyrosine content and a decreased vasorelaxation of the aorta to insulin and the glucagon-like peptide-1 analogue, liraglutide, that both could be prevented by administration of para-tyrosine.Concluding, these data suggest that meta- and ortho-tyrosine are potential markers of oxidative stress in acute diseases related to oxidative stress, and may also interfere with insulin action in septic humans. Competition of meta- and ortho-tyrosine by supplementation of para-tyrosine may exert a protective role in oxidative stress-related diseases.

show abstract

Effect of Different Stages of Chronic Kidney Disease and Renal Replacement Therapies on Oxidant-Antioxidant Balance in Uremic Patients

Cited by 73 publications

References 35 publications

Antioxidant and Anti-Inflammatory Strategies Based on the Potentiation of Glutathione Peroxidase Activity Prevent Endothelial Dysfunction in Chronic Kidney Disease

Antioxidant and Anti-Inflammatory Strategies Based on the Potentiation of Glutathione Peroxidase Activity Prevent Endothelial Dysfunction in Chronic Kidney Disease

Evaluation of Intraocular Pressure by Ocular Response Analyzer in Patients Undergoing Hemodialysis

Role of Tyrosine Isomers in Acute and Chronic Diseases Leading to Oxidative Stress - A Review

Contact Info

Product

Resources

About