Malnutrition and experimental lung allergy

Cunha, Maria Gabriela Bernardo da; Naspitz, Charles K.; Macedo-Soares, Fernanda; Amâncio, Olga Maria Silvério; Jancar, Sônia

doi:10.1111/j.1365-2222.1997.tb01159.x

Cited by 7 publications

(1 citation statement)

References 16 publications

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“…A low protein diet in balb/c mice reduces the skin responses to a histamine liberator [149], histamine [149] and allergens [150]. Defects in humoral immunity have also been shown in mice following both acute [151] and chronic starvation [152], and rat studies have shown a reduction in IgE binding sites on mast cells [153], reduction in IgE and inhibition of anaphylaxis in the lungs of sensitized animals [154], and reduction in IL‐4 and mast cells [155] when nutritional intake was reduced. Conversely, several pro‐inflammatory cytokines and mediators including IL‐6 and TNF‐α are associated with increased adipose tissue [156].…”

Section: Foods Nutrients and Allergic Diseasementioning

confidence: 99%

Nutrition and allergic disease

et al. 2006

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Summary The prevalence of asthma and allergic diseases has increased dramatically over the past few decades with the highest incidence occurring in children. Most asthma and related atopic disorders have their origins in early life. Thus, it is imperative to understand the early life origins of the disease in order to identify targets for prevention and early intervention. Although atopic diseases have genetic determinants, the increased incidence of these diseases has occurred far too rapidly for genetic changes to explain the increase. This, most likely, results from changes in environmental influences acting on a pre‐existent genetic susceptibility. One of the environmental changes over the last 20–40 years that could have contributed to the recent increase in atopic diseases is diet. Food allergy is often one of the earliest manifestations of atopy, and sensitization to food is a risk factor for the subsequent appearance of respiratory allergy and asthma. However, studies investigating the effects of dietary restrictions on the prevention of allergy have been disappointing. On the other hand, current data suggests that exclusive breastfeeding should be encouraged for at least 4–6 months in infants at both high and low risk of atopy. Increased risk of asthma has also been observed in low birth weight infants, suggesting that under‐nutrition can detrimentally alter foetal development. Epidemiological and immunological studies also suggest that dietary modification or supplementation in the foetal and early life could reduce the development of atopic diseases. The current dietary hypotheses relate to antioxidants, lipids, electrolytes and probiotics. The aims of this report are: (i) to assess the best methods to analyse nutrient intake and nutrient status; (ii) to review the existing epidemiological evidence for an association between dietary intake (nutrients and food) and allergic diseases; and (iii) to define the windows of opportunity for nutritional supplementation to be used as a preventative strategy for asthma and allergy.

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Section: Foods Nutrients and Allergic Diseasementioning

confidence: 99%

Nutrition and allergic disease

et al. 2006

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Intravenous Glutamine Administration Modulates TNF-α/IL-10 Ratio and Attenuates NFkB Phosphorylation in a Protein Malnutrition Model

et al. 2016

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Protein malnutrition (PM) is a major public health problem in developing countries, affecting the inflammatory response and increasing susceptibility to opportunistic infections. For this reason, an adequate nutritional intervention can improve the quality of life of patients. Glutamine (GLN) is a nonessential amino acid, but can be considered "conditionally essential" for macrophage function in stress situations, in which it plays a role in the improvement of the inflammatory response. Concerning this issue, in the current study, it was of interest to evaluate some biological aspects of peritoneal cells from a protein malnutrition (PM) mouse model challenged with lipopolysaccharide (LPS) and treated intravenously with GLN. Two-month-old male Balb/c mice were subjected to a low-protein diet (2 % protein) and stimulated intravenously with LPS 1 h prior to the injection of 0.75 mg/kg GLN. Malnourished animals showed a reduced number of total peritoneal cells. Malnourished animals stimulated with LPS or LPS plus GLN did not show differences in peritoneal cell counts; however, the control group showed increased cellularity after LPS stimulus, which was reversed after GLN injection. Further, in the animals from both groups stimulated with LPS, GLN decreased the circulating levels of TNF-α and the levels of TNF-α produced by peritoneal cells; additionally, GLN decreased the IL-10 circulating levels in the malnourished animals stimulated with LPS. In addition, peritoneal cells of the control and malnourished groups stimulated with LPS showed a negative modulation of the NFkB signaling pathway after GLN injection. In conclusion, this study shows that GLN has the capacity to reduce TNF-α synthesis as well as to act as a negative regulator of NFkB phosphorylation, leading to a positive outcome in the control of TNF-α production.

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Effect of body mass on exercise-induced bronchospasm and atopy in African children

Calvert

Burney

2005

Journal of Allergy and Clinical Immunology

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Malnutrition and experimental lung allergy

Cited by 7 publications

References 16 publications

Nutrition and allergic disease

Nutrition and allergic disease

Intravenous Glutamine Administration Modulates TNF-α/IL-10 Ratio and Attenuates NFkB Phosphorylation in a Protein Malnutrition Model

Effect of body mass on exercise-induced bronchospasm and atopy in African children

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