Malignomhäufigkeit und Operationsindikation der Knotenstruma im Endemiegebiet

Abstract

Goitre operations were done in 2114 patients; 1648 patients had a simple solitary nodule or multinodular goitre with regressive changes. Malignancies were found in 54 cases with a clear-cut predominance of papillary carcinomas. Nearly half of the goitres diagnosed as solitary nodules preoperatively were shown to be multinodular. This discrepancy was taken into account in the determination of the rate of malignancy. Malignomas were found in 4.6% of "true" solitary nodules and in 2.8% in multinodular goitres. These findings confirm our liberal indications for operation in multinodular goitres with regressive changes also in the area of endemic goitre. The high incidence of microcarcinomas in our patients can thus be explained.

Prevalence of Thyroid Carcinoma in Clinically Diagnosed Multinodular Goitre in a Tertiary Care Centre- A Retrospective Descriptive Study

“…It is still unclear whether thyroiditis is induced secondarily by thyroid carcinoma or thyroiditis predisposes thyroid gland to development of carcinoma. 2,27,28,29,30 The present study is an attempt to evaluate the prevalence of incidental or occult carcinoma and thyroiditis in thyroidectomies performed for benign nodular thyroid disease. The type of carcinoma associated with benign nodular disease and the duration of the nodular disease is also taken into consideration.…”