Malignant Vaginal Melanoma with Metastases to the Papilla of Vater in a Dialysis Patient: A Case Report

Abstract

Malignant vaginal melanoma is an extremely rare clinical condition, with less than 150 cases reported to date. A dialysis patient had primary vaginal melanoma with metastases to the papilla of Vater. Gastroduodenoscopy revealed a polypoid tumor. Histological findings revealed vimentin, S-100 protein, HMB45, MelanA-positive sarcoma-like cells. This staining pattern indicated that this tumor was a malignant melanoma of the papilla. Analysis of an autopsy specimen of the papilla of Vater revealed metastasis from the primary vaginal melanoma. Metastasis of a malignant tumor to the gastrointestinal tract, especially to the papilla, is uncommon. Melanoma should be considered in the differential diagnosis of primary gastrointestinal tract malignancy.

A Case of Obstructive Jaundice Caused by Metastasis of Ovarian Cancer to the Duodenal Major Papilla

“…In addition, many reported cases to date stated breast cancer, kidney cancer, or malignant melanoma as the primary lesion. [5][6][7][8][9] There is only one reported case of obstructive jaundice caused by ovarian cancer due to extramural pushing/infiltration from lymph node metastasis. 12 To the best of our knowledge, there has been no reported case of obstructive jaundice caused by direct metastasis to the duodenal major papilla.…”

“…Almost all intrabiliary tumors that cause obstructive jaundice originate in the biliary duct, although there are reports of rare cases of biliary/papillary metastasis arising from colorectal cancer, breast cancer, lung cancer, malignant melanoma, and other malignancies. [2][3][4][5][6][7][8][9] Obstructive jaundice caused by metastatic biliary tract/papillary lesions sometimes occurs because of compression or infiltration of bile ducts due to widespread liver metastases, or in exceptional cases, because of direct metastatic involvement of the extrahepatic bile ducts and duodenal major papilla in the absence of hepatic lesions. 7,10,11 We present a case of obstructive jaundice caused by direct metastasis to the duodenal major papilla from ovarian cancer that was treated surgically 11 years ago.…”

Diagnostic benefit of cytological and histopathological examinations for recurrent vaginal cancer metastasizing to the duodenum: A case report

“…Though vaginal cancer may invade locally and disseminate by hematogenous and lymphatic routes, 4 a metastasis to the duodenum is extremely rare. Only 1 case report of vaginal malignant melanoma with metastasis to the papilla of Vater can be found on PubMed 6 . Herein, we report a case of recurrent vaginal cancer metastasizing to the duodenum, for which cytological and histopathological examinations were useful for obtaining a diagnosis.…”

Uterine cervix squamous cell carcinoma metastatic to the Ampulla of Vater: a case report with review of the literature

“…Metastases to the gastrointestinal tract (GI) tract are uncommon, while metastases to the ampulla of Vater are extremely rare and therefore may pose a signifi cant diagnostic pitfall. Not many cases of metastasis to the ampulla of Vater are described, most of them being metastasis of primary melanoma of the skin (3)(4)(5)(6)(7), renal cell carcinomas (8)(9)(10) and a few cases of squamous cell carcinoma (SCC) from diff erent primary sites (11)(12)(13). SCC of the uterine cervix is likely to early metastasize into the adjacent lymph nodes, but hematogenous dissemination is the least common metastatic pathway of this carcinoma (14).…”