Malignant Tumours of the Paranasal Sinuses and Nasal Cavity a Series of 180 Patients

Gadeberg, C.; Hjelm-Hansen, M.; Søgaard, H; Elbrønd, O.

doi:10.3109/02841868409136009

Cited by 33 publications

(4 citation statements)

References 7 publications

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“…An association between exposure to a mixture of hard and soft wood dust and an increased risk of epidennoid and anaplastic carcinoma of the nasal cavity has also been suggested [Hernberg et al, 19831. Thus there is evidence that the carcinogenic factor(s) is present in soft woods as well as hard woods [Acheson, 1976;Elwood, 1981;Hernberg et al, 1983;Gadeberg et al, 1984;Gallagher and Threlfall, 1985;Voss et al, 1985;Hayes et al, 1986;Bolm-Audorff et al, 19891. The type of wood dust to which the worker is exposed (predominantly hard or soft wood) seems to determine the major tumor type.…”

Section: Risk Factorsmentioning

confidence: 99%

Carcinogenic effects of wood dust: Review and discussion

L¹,

Dement

1993

American J Industrial Med

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Occupational exposure to wood dust (alone or chemically treated) is associated with an increased risk of developing adenocarcinoma of the nasal cavity. The specific causative agents, i.e., wood dust alone (natural products), wood dust with additives used in the processing or manufacturing of wood products, and/or physical determinants of wood dust and the associated risk factors, are not known or understood. The strongest association of exposure to wood dust and development of nasal cancer is observed in those occupations where workers are exposed to hard wood dust and chemical additives are not used. The time between first occupational exposure to wood dust and the development of adenocarcinoma of the nasal cavity averages 40 years (range 7-70 years). The epidemiological data available are not sufficient to make a definitive assessment between wood dust exposure and increased risk for cancer other than nasal cancer. The toxicity, mutagenicity, and carcinogenicity of wood dust to laboratory animals or in vitro with animal or microbial cells have not been thoroughly studied. Thus there is no direct experimental evidence on the potential hazards of wood dust. Data are insufficient or lacking on 1) wood dust exposure levels in ambient air and worker's breathing zone, and the deposition in the nasal cavity; 2) hard vs. soft wood dusts; 3) particle size and shape; 4) chemical composition of wood dust and the extent of contamination with chemical additives; and 5) interaction between inhaled wood dust, chronic irritation, and tobacco smoking. These data are required so that one can understand the association between wood dust exposure and nasal cavity tumors, along with demographic differences in cancer rates, and to develop strategies for intervention and reduction of disease causing agents in order to reduce risk to wood industry workers.

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Section: Risk Factorsmentioning

confidence: 99%

Carcinogenic effects of wood dust: Review and discussion

L¹,

Dement

1993

American J Industrial Med

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“…In 1984, a paper from our centre, studying classification and prognosis for 180 malignant tumours in the nasal cavity and paranasal sinus, was published (2). This niaterial has been thoroughly re-evaluated and is included in the present series.…”

mentioning

confidence: 99%

Cancer of the Nasal Cavity and Paranasal Sinuses:A Clinico-pathological Study of 277 Patients

et al. 1997

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“…Due to early recognition and easy access to treatment, they usually have a more favourable prognosis than their counterpart of the sinonasal region. Sinonasal keratinising squamous cell carcinoma represents up to 45-50% of the malignant tumours of this region in several series [93,259]. At the Hospital Clinic of the University of Barcelona, where non-keratinising squamous cell carcinomas (see Sect.…”

Section: Icd-o:8071/3mentioning

confidence: 99%