Cancer of the Nasal Cavity and Paranasal Sinuses:<i>A Clinico-pathological Study of 277 Patients</i>

Harbo, Grethe; Grau, Cai; Bundgaard, Troels; Overgaard, Marie; Elbrønd, O.; Søgaard, H; Overgaard, Jens

doi:10.3109/02841869709100731

Cited by 139 publications

(116 citation statements)

References 21 publications

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“…Poor prognosis was also associated with a mixed anatomic location (p \ 0.0001), a high stage at presentation (stage IV, p \ 0.013), skull base involvement (p = 0.005), recurrence (p \ 0.0001), and a predominantly ([70 %) solid histology (p = 0.006). Although with variable results, these findings are supported by others who have studied individual factors [45].…”

Section: Prognosissupporting

confidence: 68%

“…p16 overexpression was seen in all of our cases (luminal nuclear and cytoplasmic reaction; stronger cytoplasmic reaction than in those cases that had associated pleomorphic adenoma), but does not necessarily imply biologically integrated HPV as a potential etiology, as it does with oropharyngeal carcinoma [12]. None of the cases tested contained high-risk HPV (which includes 16,18,31,33,35,39,45,51,52,56,58, and 66) by in situ hybridization, different from a recent series reporting the presence of HPV 33 specifically [141].…”

Section: Immunohistochemical Studiesmentioning

confidence: 59%

“…The overall mortality rate was 53 % (mean 6.5 years). The overall survival for STACC of 67.4 % at 5-years is better than for age-and stage-matched patients with sinonasal tract squamous cell carcinoma with 34-57 % alive at 5-years [11,44,45]. However, for STACC, the prolonged nature of the disease suggests that the histologic type and not just the stage must be taken into consideration when planning management and follow-up protocols.…”

Section: Prognosismentioning

confidence: 99%

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Sinonasal Tract and Nasopharyngeal Adenoid Cystic Carcinoma: A Clinicopathologic and Immunophenotypic Study of 86 Cases

Thompson

Penner

Ho³

et al. 2013

Head and Neck Pathol

119

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'Primary sinonasal tract and nasopharyngeal adenoid cystic carcinomas (STACC) are uncommon tumors that are frequently misclassified, resulting in inappropriate clinical management. Eighty-six cases of STACC included 45 females and 41 males, aged 12-91 years (mean 54.4 years). Patients presented most frequently with obstructive symptoms (n = 54), followed by epistaxis (n = 23), auditory symptoms (n = 12), nerve symptoms (n = 11), nasal discharge (n = 11), and/or visual symptoms (n = 10), present for a mean of 18.2 months. The tumors involved the nasal cavity alone (n = 25), nasopharynx alone (n = 13), maxillary sinus alone (n = 4), or a combination of the nasal cavity and paranasal sinuses (n = 44), with a mean size of 3.7 cm. Patients presented equally between low and high stage disease: stage I and II (n = 42) or stage III and IV (n = 44) disease. Histologically, the tumors were invasive (bone: n = 66; neural: n = 47; lymphovascular: n = 33), composed of a variety of growth patterns, including cribriform (n = 33), tubular (n = 16), and solid (n = 9), although frequently a combination of these patterns was seen within a single tumor. Pleomorphism was mild with an intermediate N:C ratio in cells containing hyperchromatic nuclei. Reduplicated basement membrane and glycosaminoglycan material was commonly seen. Necrosis (n = 16) and atypical mitotic figures (n = 11) were infrequently present. Pleomorphic adenoma was present in 9 cases; de-differentiation was seen in two patients. Immunohistochemical studies showed positive reactions for pan-cytokeratin, CK7, CK5/6, CAM5.2, and EMA, with myoepithelial reactivity with SMA, p63, calponin, S100 protein and SMMHC. CD117, CEA, GFAP and p16 were variably present. CK20 and HR HPV were negative. STACC needs to be considered in the differential diagnosis of most sinonasal malignancies, particularly poorly differentiated carcinoma, olfactory neuroblastoma and pleomorphic adenoma. Surgery (n = 82), often accompanied by radiation therapy (n = 36), was generally employed. A majority of patients developed a recurrence (n = 52) 2-144 months after initial presentation. Overall mean follow-up was 19.4 years (range 0.4-37.5 years): 46 patients died with disease (mean 6.4 years); 5 were alive with disease (mean 5.4 years), and 35 patients were either alive or had died of unrelated causes (mean 16.3 years). ACC of the SNT is uncommon. Recurrences are common. The following parameters, when present, suggest an increased incidence of either recurrence or dying with disease: mixed site of involvement, high stage disease (stage IV), skull base involvement, tumor 123Head and Neck ) 8:88-109 DOI 10.1007 recurrence, a solid histology, perineural invasion, bone invasion, and lymphovascular invasion.

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Section: Prognosissupporting

confidence: 68%

Section: Immunohistochemical Studiesmentioning

confidence: 59%

Section: Prognosismentioning

confidence: 99%

See 1 more Smart Citation

Sinonasal Tract and Nasopharyngeal Adenoid Cystic Carcinoma: A Clinicopathologic and Immunophenotypic Study of 86 Cases

Thompson

Penner

Ho³

et al. 2013

Head and Neck Pathol

119

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“…Malignant tumors originating from the nose or the paranasal sinuses are rare, [1][2][3][4] representing 3% of all malignancies of the head and neck region. [1][2][3]5,6 They arise in air-filled cavities, which usually become infiltrated by tumor before signs and symptoms develop; therefore, most patients at diagnosis present with advanced stage disease and have extensive involvement of adjacent sites.…”

Section: Introductionmentioning

confidence: 99%

Paranasal sinus squamous cell carcinoma incidence and survival based on Surveillance, Epidemiology, and End Results data, 1973 to 2009

Ansa

Goodman

Ward

et al. 2013

Cancer

175

171

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BACKGROUND: Paranasal sinus squamous cell carcinomas (PNSSCC) account for 3% of all head and neck malignancies. There has been little information on the trends in incidence and survival, and no randomized trials have been conducted to guide therapy. METHODS: Patients with PNSSCC reported to the Surveillance, Epidemiology, and End Results (SEER) Program from 1973 through 2009 were categorized by sex, age, year of diagnosis, primary site, stage, and treatment. The incidence and survival were then compared across different demographic and disease-related categories by calculating rate ratios (RRs) and mortality hazard ratios along with the corresponding 95% confidence intervals (CIs). RESULTS: In total, 2553 patients with PNSSCC were identified. While incidence of PNSSCC showed a gradual decline, survival remained largely unchanged.

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“…9,10,11 Primary sinonasal mucosal melanoma is a rare entity, which constitutes about 1.5-9% of all malignancies in this site. 12,13 Sinonasal melanoma tends to have a high rate of locoregional and distant failure and to carry poor outcome with a median survival of 9-52 months and an overall 5-year survival rate of 0% to 50%. [4][5][6][7][8] To date, more than one thousand cases of sinonasal melanomas have been reported in the literature.…”

Section: Discussionmentioning

confidence: 99%

Melanoma primário de mucosa do trato nasossinusal: relato de 18 pacientes e análise de 1077 pacientes na literatura

Khademi¹,

Bahranifard²,

Nasrollahi³

et al. 2011

Braz. j. otorhinolaryngol. (Impr.)

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The present study aimed at reporting on the characteristics, prognostic factors and treatment outcomes of 18 cases of nasosinusal mucosa melanoma, and do a literature review on the subject.Methods: between 1995 and 2005, 18 patients consecutively diagnosed with nasosinusal mucosa melanoma were managed in our institution. We reviewed the literature in PubMed and Scopus in order to find the main series from studies associated with this topic. We found a total of 35 series, involving 1,077 patients with nasosinusal mucosa melanoma.Results: we found 16 men and 2 women, with age at presentation between 51 and 80 years (median of 58 years). All these patients were submitted to surgical excision followed by radiotherapy with or without chemotherapy. The survival median was 15 months, and the 5-year general survival had a percentage value of 23%. Considering our univariate analysis: tumor staging and complete remission after initial treatment were deemed relevant prognostic factors. Nonetheless, considering the multivariate analysis, only disease stage was statistically significant. Conclusion:nasosinusal melanoma is a rare and aggressive tumor, with high loco-regional and distant failure rates, and poor treatment outcomes. Notwithstanding, in a literature review we found significant improvements considering the 5-year survival for recent series when compared to previously reported ones. Braz J Otorhinolaryngol. 2011;77(1):58-64. ORIGINAL ARTICLE

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Cancer of the Nasal Cavity and Paranasal Sinuses:A Clinico-pathological Study of 277 Patients

Cited by 139 publications

References 21 publications

Sinonasal Tract and Nasopharyngeal Adenoid Cystic Carcinoma: A Clinicopathologic and Immunophenotypic Study of 86 Cases

Sinonasal Tract and Nasopharyngeal Adenoid Cystic Carcinoma: A Clinicopathologic and Immunophenotypic Study of 86 Cases

Paranasal sinus squamous cell carcinoma incidence and survival based on Surveillance, Epidemiology, and End Results data, 1973 to 2009

Melanoma primário de mucosa do trato nasossinusal: relato de 18 pacientes e análise de 1077 pacientes na literatura

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