Malignant transformation within benign adnexal skin tumours

Abstract

The growth stimulus in these benign adnexal neoplasms resulting in malignant transformation may be attributed to the acquisition of additional genetic events or to immunosuppression due to an underlying neoplastic disease. Therefore, patients with systemic diseases or malignancy should be carefully examined and followed for sudden changes in pre-existing benign cutaneous tumours.

Multiple eccrine poromas in the setting of total body irradiation and immunosuppression

“…In addition, malignant transformation of eccrine poroma has been reported. 2,[19][20][21] This may be of particular concern in an immunocompromised patient, warranting careful monitoring by a dermatologist.…”

Characterizing pilomatricomas in children: a single institution experience

“…The term "pilomatrix carcinoma" was used for the first time in 1980 by Lopansri and Minm [43] to describe a pilomatricoma with numerous abnormal mitotic figures and an infiltrative border. Pilomatrix carcinomas have been further described as having enlarged epithelial cells, clusters of undifferentiated basaloid cells, invasion of adjacent blood vessels, and infiltration of capsular tissue [2,44]. In comparison with benign lesions, pilomatrix carcinomas most commonly affect middle-aged males, although a case of pilomatrix carcinoma in an 8-year-old girl has been reported [45][46][47].…”

Primary cutaneous carcinosarcoma: case report with expanded immunohistochemical analysis

“…A summary of the clinicopathologic features of primary cutaneous CS based on a literature review 1–12 is given in Table 2. As some reports did not provide complete information, the total numbers of cases analyzed differ for some characteristics.…”

“…A single characteristic that differentiated cases in which sarcomatous development appeared was the older age of the patients whose BCCs were transplanted. Recently, two reports of cutaneous CS described it as trichoblastic CS 4 or malignant biphasic trichogenic tumor, 5 based on the presence of immature hair buds and abortive papillae. Nevertheless, the possibility that the tumor was initially nodular BCC with unusually prominent differentiation towards follicular germs and papillae that developed a malignant mesenchymal component has not been excluded 4 .…”