Characterizing pilomatricomas in children: a single institution experience

Enlarging tumor of the lateral chest wall in a 14‐year‐old boy

“…Pilomatricoma is a benign adnexal tumor that arises from hair matrix cells [ 1 ] . The majority of these tumors show a mutation of the CTNNB1 gene (3p22-p21.3), resulting in upregulation of -catenin, thus promoting cell growth and proliferation [ 2,3 ] .…”

“…While classic pilomatricoma is a common tumor in childhood, there is another incidence peak after the 6th decade of life [ 3 ] . The induration is attributable to calcifi cation and present in 84 % of cases; histological evidence of ossification is found in 21 % [ 1 ] .…”

A Compressible Bulla on the Upper Back of a Teen

“…Unlike classic pilomatricomas, the uncommon bullous pilomatricoma variant has not been reported in association with genetic syndromes, nor have there been reports of bullous pilomatricomas transforming to malignant pilomatricarcinomas . Surgical excision with negative margins is the accepted standard of care for treatment of all pilomatricomas, and postexcision recurrence rates are low .…”

Childhood pilomatricomas: Associated anomalies

“…There are two peaks of occurrence: childhood and in the sixth decade of life. In children, pilomatricomas occur between the ages of 6 to 11 . The head and neck are the most common locations (45%‐71%), but pilomatricomas can arise at any site, including the upper limbs (18%‐45.5%), trunk (4%‐14%) and lower limbs (< 5%) .…”

“…In children, pilomatricomas occur between the ages of 6 to 11. [2][3][4][5][6][7] The head and neck are the most common locations (45%-71%), but pilomatricomas can arise at any site, including the upper limbs (18%-45.5%), trunk (4%-14%) and lower limbs (< 5%). 2 A single pilomatricoma is the usual presentation, but multiple pilomatricomas have been reported.…”