Malignant transformation of oral lichen planus by a chronic inflammatory process. Use of topical corticosteroids to prevent this progression?

Abstract

The maintenance of a minimum dose of topical corticosteroids could prevent the inflammatory progression of oral lichen planus to oral cancer.

Expression of CD133 in various premalignant and proliferative lesions

“…Inflammatory process is able to create a microenvironment that can affect the growth, proliferation and differentiation of cells that end up on the condition of genetic mutations. 26 Mutated cells will lead to uncontrolled proliferation and known malignancy (cancer). Stem cells are also influenced by micro-environmental conditions surrounding and under certain conditions can be transformed into stem cells, called cancer stem cells.…”

“…Socio-demographic characteristics of this study showed that premalignant lesions are more common in women than men, aged over 40 years and this is in accordance with many other studies. 24,26 Tongue is the most common predilection of PML compared to other area. This result is also the same with many other studies.…”

Precáncer y cáncer bucal

“…Algunos investigadores muestran una prevalencia del 0,1 al 4%, y la mayoría de los pacientes son mujeres mayores de 50 añ os y en período posmenopá usico. La clasificació n clínica má s sencilla consiste en 3 formas, denominadas liquen plano oral (LPO) reticular (blanco), LPO atró fico-erosivo (rojo), y la combinació n de ambos; la reticular es la forma má s frecuente 34 . El LPO atró fico-erosivo aparece principalmente en la lengua, la mucosa yugal y la encía.…”

“…Entre los factores desencadenantes tiene un papel relevante el factor psicoló gico, y su asociació n con enfermedades sisté micas como la hepatitis C, la diabetes o la hipertensió n es discutida 36 . Es importante realizar controles perió dicos, ya que tiene potencial de malignidad 34,37 . Tambié n es primordial recordar que hay una serie de lesiones difíciles de distinguir de las manifestaciones clínicas del LPO: son las denominadas reacciones liquenoides.…”

Oral Lichen Planus: Diagnosis and Management

“…23 Anyhow, such malignant transformation can not be prevented, although it has been speculated that the use of topical steroids may prevent such event. 24 …”