Precáncer y cáncer bucal

López‐López, José; Omaña-Cepeda, Carlos; Jané‐Salas, Enric

doi:10.1016/j.medcli.2014.11.014

Cited by 12 publications

(4 citation statements)

References 52 publications

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“…in patients treated with OSCC. The dentist's attitude towards oral cancer should be aimed at preventing the disease (recognizing and controlling premalignant lesions and eliminating local chronic irritants), early diagnosis through examinations at periodic visits, providing adequate information to the patient (both in terms of prevention and of the disease itself), referral and reorientation of cancer patients to cancer treatment units and preventive dental treatment in those patients who are going to receive cancer treatment ( 3 ). For these reasons, this same group could play a fundamental role in its early detection using future reliable diagnostic tools ( 7 ).…”

Section: Discussionmentioning

confidence: 99%

“…It is recognized that more than 90% are oral cavity squamous cell carcinomas (OSCC) ( 1 , 2 ). On many occasions, the presence of oral premalignant (or potentially malignant) lesions (OPML) in the oral mucosa warns of the future malignancy of the process ( 3 ). The diagnosis of OSCC is based on a clinical diagnosis, based on visual inspection and the ability to detect alterations in the oral mucosa, followed by a biopsy of the suspicious tissue and its histopathological analysis ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

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Role of selected salivary inflammatory cytokines in the diagnosis and prognosis of oral squamous cell carcinoma. A Systematic Review and Meta-analysis

Benito-Ramal¹,

Egido-Moreno²,

González-Navarro³

et al. 2023

Med Oral

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Background Oral squamous cell carcinoma (OSCC) is gradually increasing its incidence in our society. Unfortunately, this entity is diagnosed at an advanced stage in most patients, a fact that implies greater difficulty in its treatment and a worse prognosis. This systematic review aims to assess whether the cytokines IL-6, IL-8 and TNF-α are potential salivary biomarkers that allow early diagnosis of cancer. Material and Methods An electronic search was performed in three databases (Pubmed, Scopus and Web of Science). We used the following keywords: "salivary cytokines", "saliva cytokines", "salivary interleukins", "biomarkers", "oral squamous cell carcinoma" and "diagnosis", combined with the Boolean operators "AND" and "OR". Results 128 publications were found and finally 23 articles were included in the review and 15 in the meta-analysis. It has been observed that the majority of OSCC patients express higher salivary concentrations of IL-6, IL-8 and TNF-α compared to the control (CL) and premalignant lesion (OPML) groups. It has also been observed that the different premalignant lesions do not have statistically significant differences in the salivary concentration of the cytokines, and on the other hand, differences have been observed between the different TNM stages. The meta-analysis has shown that the difference in concentration of IL-6, IL-8 and TNF-α is statistically significant between the CL group and the OSCC, and also between the CL group and OPML. Conclusions There is sufficient evidence to affirm that IL-6, IL-8 and TNF-α are useful salivary cytokines in the early diagnosis and prognosis of OSCC. Although future studies are necessary to establish greater reliability of these biomarkers and thus be able to develop a valid diagnostic test. Key words: Salivary cytokines, IL-6, IL-8, TNF-α, oral squamous cell carcinoma, diagnosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of selected salivary inflammatory cytokines in the diagnosis and prognosis of oral squamous cell carcinoma. A Systematic Review and Meta-analysis

Benito-Ramal¹,

Egido-Moreno²,

González-Navarro³

et al. 2023

Med Oral

View full text Add to dashboard Cite

show abstract

“…Ante la sospecha de una úlcera neoplásica, se deberá realizar una biopsia incisional de la lesión; si el resultado histopatoló-gico confirma el diagnóstico de sospecha de carcinoma de células escamosas, se derivará al paciente de inmediato a su centro de referencia, donde diferentes especialistas (oncólogos, cirujanos orales y maxilofaciales, radioterapeutas, quimioterapeutas, odontólogos, psicólogos y nutricionistas) proporcionarán el tratamiento más adecuado de acuerdo al estadio (TNM) en que se encuentre el tumor 12 .…”

Section: Tratamiento De Las úLceras Neoplásicasunclassified

“…Frente a este proceso patológico es recomendable realizar un análisis sanguíneo completo, que incluya hemograma, ácido fólico, ferritina y vitamina B 12 , para descartar posibles causas sistémicas o enfermedades de base como deficiencias vitamínicas, enfermedades gastrointestinales o deficiencias inmunitarias (tabla 1) y, eventualmente, tratarlas 5,13 . …”

Section: Tratamiento De Las Aftasunclassified