Malignant Transformation of Hepatocellular Adenoma

Abstract

The patient was a 20-year-old male in whom a hepatic hypervascular mass accompanied by intratumoral hemorrhage was detected on examination for epigastric pain. Based on the enlargement of the mass and diagnostic imaging, hepatocellular adenoma (HCA) was suspected and hepatectomy was performed. The lesion was diagnosed as malignant transformation of β-catenin-activated HCA. There are only few reports of cases with malignant transformation of HCA in Japan; it is necessary to accumulate cases to investigate it.

Malignant transformation of liver fatty acid binding protein-deficient hepatocellular adenomas: histopathologic spectrum of a rare phenomenon

“…Two of these patients had follow-up information (1 year and 9 years) with no evidence of recurrent disease. Twenty-six additional β-catenin mutated hepatocellular adenoma patients with malignant transformation previously reported in the literature were included in the analysis [12][13][14][15][16][17][18][19][20][21][22]. These patients were mostly male (65% male and 35% female) with an average age of 42 ± 14 years at the time of diagnosis (range: 20-66 years).…”

“…CharacteristicsLFABP-deficient hepatocellular adenomas β-catenin mutated hepatocellular adenomas a[12][13][14][15][16][17][18][19][20][21][22] P value HCC hepatocellular carcinoma, LFABP liver fatty acid binding protein, BCS Budd-Chiari syndrome, MODY maturity-onset diabetes of the young, DM diabetes mellitus, OCP oral contraceptive pills, GSD glycogen storage disease a β-catenin mutated hepatocellular adenoma cases included 4 cases from primary authors' institution and 26 cases from the literature[12][13][14][15][16][17][18][19][20][21][22] (see Supplementary Table1for details)…”

Hepatocellular adenoma, approximately half and predominantly inflammatory subtype, in 38 Japanese patients with several differences in age, gender, and clinical background factors from Western populations

“…Our results differ in some respects from those of the other two Japanese reports, 8,9 as shown in Table 2, which may reflect differences in the number of HCA cases examined, specimens being Association with HCA and HCC were found in three cases out of 38 HCA cases examined. In Japan, reports of malignant transformation of HCA are few, 13 such that the observations made in this investigation are important. Sasaki et al 8 reported one of their 13 cases (7.7%) to…”

“…Association with HCA and HCC were found in three cases out of 38 HCA cases examined. In Japan, reports of malignant transformation of HCA are few,13 such that the observations made in this investigation are important. Sasaki et al8 reported one of their 13 cases (7.7%) to show an association between HCA and HCC, while three of our 38 cases (7.9%) showed such an association.…”

A New Horizon in Liver Disease

“…Kwok et al [4] report a case of malignant transformation of hepatocellular adenoma (HCA) in a 20-year-old male; this disease is very rare in Japan. Although the factors underlying HCA development are unclear, the diagnosis of β-catenin-activated HCA was correct in this case, in which HCC with similar immunopathological features and structural atypia might have developed from β-catenin-activated HCA.…”