Hepatocellular adenoma, approximately half and predominantly inflammatory subtype, in 38 Japanese patients with several differences in age, gender, and clinical background factors from Western populations

Izu, Asami; Sugitani, Masahiko; Kinukawa, Noriko; Matsumura, Hiroshi; Ogawa, Masahiro; Moriyama, Mitsuhiko; Yamazaki, Shintaro; Takayama, Tadatoshi; Hano, Hiroshi; Yao, Takashi; Kanda, Hiroaki; Suzuki, Koyu; Hayashi, Seisyu; Ariizumi, Syunichi; Yamamoto, Masakazu; Morishita, Yukio; Matsumoto, Koshi; Nakamura, Naoya; Nakano, Masayuki

doi:10.1111/hepr.13613

Cited by 7 publications

(8 citation statements)

References 11 publications

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“…In western countries, only ~10% of HCAs are observed in males. A slight male preponderance or a practically equal distribution of male and female patients have been reported in studies from eastern countries with very low OC use 22,113,114 . In these studies, IHCA was the most frequent subtype observed both in the total study population and in the male patients.…”

Section: Hca In Particular Clinicopathological Contextsmentioning

confidence: 67%

“…A slight male preponderance or a practically equal distribution of male and female patients have been reported in studies from eastern countries very low OC use. 22,113,114 In these studies, IHCA was the most frequent subtype observed both in the total study population and in the male patients. Overweight and obesity were associated with the IHCA subtype in two of the three studies, 22,113 and the third study 114 mentioned excessive alcohol intake in all IHCA patients but none patients with the other subtypes.…”

Section: H C a I N M A L E Smentioning

confidence: 79%

“…In these studies, IHCA was the most frequent subtype observed both in the total study population and in the male patients. Overweight and obesity were associated with the IHCA subtype in two of the three studies, 22,113 and the third study 114 mentioned excessive alcohol intake in all IHCA patients but none patients with the other subtypes. It is of note that a recent study from Turkey mentioned a female preponderance of HCA despite low numbers of patients using OCs in the study population 115 …”

Section: Hca In Particular Clinicopathological Contextsmentioning

confidence: 92%

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Hepatocellular adenoma: what we know, what we do not know, and why it matters

et al. 2022

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Hepatocellular adenoma: what we know, what we do not know, and why it mattersIn the last two decades there has been significant progress in research on and diagnosis of hepatocellular adenoma (HCA), resulting in the establishment of a molecular and immunohistological HCA classification. This review aims to fine-tune the current expertise in order to enhance the histopathological diagnostic possibilities, by refining issues that are already known, addressing diagnostic difficulties, and identifying still unknown aspects of HCA. We discuss novel methods to identify HCA subtypes, in particular the sonic hedgehog HCAs and the interpretation of glutamine synthetase patterns for the recognition of b-cateninmutated HCAs. The major complications of HCAs, i.e. bleeding and malignant transformation, are considered, including the dilemmas of atypical and borderline lesions. HCAs in different clinical and geographical settings, e.g. pregnancy, cirrhosis and non-western countries, are also discussed. The natural history of the different HCA subtypes in relation to age, sex and risk factors is a feature that is still insufficiently investigated. This is also true for the risks of clinical bleeding and malignant transformation in association with HCA subtypes. As HCA is a relatively rare tumour, a multicentre and multidisciplinary approach across geographical boundaries will be the appropriate method to establish prospective programmes with which to identify, classify and manage HCAs, focusing on several aspects, e.g. aetiology, underlying liver disease, complications, regression, and growth. Updating what we know and identifying and addressing what we do not know matters for optimal patient management.

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Section: Hca In Particular Clinicopathological Contextsmentioning

confidence: 67%

Section: H C a I N M A L E Smentioning

confidence: 79%

Section: Hca In Particular Clinicopathological Contextsmentioning

confidence: 92%

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Hepatocellular adenoma: what we know, what we do not know, and why it matters

et al. 2022

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“…However, epidemiological data from Asia, where the use of OCPs and the incidence of obesity are lower, are unclear. Limited studies from Taiwan, China and Japan showed a male predominance in patients with HCA[ 7 - 11 ]. Further exploration of these epidemiological differences is needed to better understand the pathogenesis of HCA.…”

Section: Introductionmentioning

confidence: 99%

Hepatocellular adenoma: Where are we now?

Wang¹,

Zhang²

2022

WJG

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Hepatocellular adenoma (HCA) is a benign hepatocellular neoplasm, commonly occurs in young women with a history of oral contraceptive use. Complications including hemorrhage and malignant transformation necessitate the need for a thorough understanding of the underlying molecular signatures in this entity. Recent molecular studies have significantly expanded our knowledge of HCAs. The well-developed phenotype-genotype classification system improves clinical management through identifying “high risk” subtype of HCAs. In this article, we attempt to provide updated information on clinical, pathologic and molecular features of each subtype of HCAs.

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“… 5 Thus, our high proportion of β-HCA or β-IHCA (40%) is in accordance with the literature. I-HCA represents the major subtype in surgical series, 10 more often resected than H-HCA due to the risk of malignant transformation and the potential association with β-catenin mutations. Moreover, I-HCA resected in our study were large tumors, with a mean size of 9.2 cm (5.5-16), all of which were larger than 5 cm.…”

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confidence: 99%

Reply to: “Malignant transformation of hepatocellular adenoma”

et al. 2022

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Hepatocellular adenoma, approximately half and predominantly inflammatory subtype, in 38 Japanese patients with several differences in age, gender, and clinical background factors from Western populations

Cited by 7 publications

References 11 publications

Hepatocellular adenoma: what we know, what we do not know, and why it matters

Hepatocellular adenoma: what we know, what we do not know, and why it matters

Hepatocellular adenoma: Where are we now?

Reply to: “Malignant transformation of hepatocellular adenoma”

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