Malignant transformation of fibrous dysplasia into angiosarcoma

Oh, Song Hee; Kang, Ju Hee; Seo, Yu-Kyeong; Kim, Jin Ho; Choi, Yong-Suk; Hwang, Eui-Hwan

doi:10.1007/s11282-019-00404-2

Cited by 5 publications

(2 citation statements)

References 13 publications

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“…Some cases of MS are associated with McCune-Albright syndrome (MAS), which is characterized by café-au-lait spots on the skin and endocrine abnormalities[ 8 ]. Previous studies have reported that although FD is usually a benign lesion, malignant transformation can occur over time[ 9 ]. The possible outcomes of disease deterioration include osteosarcoma, fibrosarcoma, chondrosarcoma and malignant fibroistiocytoma.…”

Section: Discussionmentioning

confidence: 99%

Mazabraud’s syndrome in female patients: Two case reports

Li,

Chen,

Wang

et al. 2024

World J Orthop

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BACKGROUND Mazabraud’s syndrome (MS) is a rare and slowly progressive benign disease characterized by the concurrent presence of fibrous dysplasia of bone and intramuscular myxoma, and is thought to be associated with mutations of the GNAS gene. To date, only about 100 cases of MS have been reported in the literature, but its standard treatment strategy remains unclear. CASE SUMMARY We report two cases of MS in young women who underwent different treatments based on their symptoms and disease manifestations. The first patient, aged 37, received internal fixation and intravenous bisphosphonate for a pathological fracture of the right femoral neck, excision of a right vastus medialis myxoma was subsequently performed for pain control, and asymptomatic psoas myxomas were monitored without surgery. Genetic testing confirmed a GNAS gene mutation in this patient. The second patient, aged 24, underwent right vastus intermedius muscle myxoma resection, and conservative treatment for fibrous dysplasia of the ilium. These patients were followed-up for 17 months and 3 years, respectively, and are now in a stable condition. CONCLUSION Various treatments have been selected for MS patients who suffer different symptoms. The main treatment for myxomas is surgical resection, while fibrous dysplasia is selectively treated if the patient experiences pathological fracture or severe pain. However, given the documented instances of malignant transformation of fibrous dysplasia in individuals with MS, close follow-up is necessary.

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Section: Discussionmentioning

confidence: 99%

Mazabraud’s syndrome in female patients: Two case reports

Li,

Chen,

Wang

et al. 2024

World J Orthop

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“…(82)(83)(84)(85)(86)(87)(88)(89)(90)(91). However, reports of malignancy arising from FD suggest the affected body region should be under long-term monitoring (90,91). Patients with FD have an increased risk of developing breast cancer (92).…”

Section: Fibrous Dysplasiamentioning

confidence: 99%

Symptomatic Mandibular Fibrous Dysplasia With Concurrent Triple X- and Premutation Stage Fragile-X-Syndrome: Case Report With Short Literature Survey

2019

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Background: Certain constitutive chromosomal abnormalities of the human X chromosome are relatively common in conspicuous neuropsychiatric findings. Although tumors or tumor-like lesions are occasionally reported in diseases of the X chromosome, they are numerically negligible, for example, in aneuploidy such as the triple X syndrome (TXS). Case Report: A 16-year-old female patient with a known TXS and premutation stage of fragile X syndrome was referred by her dentist for diagnosis and treatment of unilateral cheek swelling. The examination of the psychologically conspicuous patient revealed a unilateral mandibular tumor with dysesthesia of the mental nerve. Surgical removal of soft, crumbly spongiosa over the nerve canal resulted in sufficient pressure release of the constricted nerve and restoration of epicritic sensitivity. Imaging findings and histological and molecular genetic examination revealed monostotic craniofacial fibrous dysplasia. Conclusion: Although the data in the literature do not give reason to suppose an accumulation of neoplasms in TXS, a numb chin syndrome should be a reason for detailed diagnostics. Careful diagnosis allows for customized therapy. This is the first report on the coincidence of TXS, fragile X syndrome, and fibrous dysplasia in a single individual.

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Three-Dimensional Accuracy of Bone Contouring Surgery for Zygomaticomaxillary Fibrous Dysplasia Using Virtual Planning and Surgical Navigation

Liu

Zhang

et al. 2020

Journal of Oral and Maxillofacial Surgery

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Malignant transformation of fibrous dysplasia into angiosarcoma

Cited by 5 publications

References 13 publications

Mazabraud’s syndrome in female patients: Two case reports

Mazabraud’s syndrome in female patients: Two case reports

Symptomatic Mandibular Fibrous Dysplasia With Concurrent Triple X- and Premutation Stage Fragile-X-Syndrome: Case Report With Short Literature Survey

Three-Dimensional Accuracy of Bone Contouring Surgery for Zygomaticomaxillary Fibrous Dysplasia Using Virtual Planning and Surgical Navigation

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