Malignant Transformation in Monostotic Fibrous Dysplasia

Qu, Nan; Yao, Weiwu; Cui, Xiaojiang; Zhang, Huizhen

doi:10.1097/md.0000000000000369

Cited by 60 publications

(17 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The estimated prevalence of malignant transformation has been estimated to range from 0.4 to 6.7% [8] whereas it was 9% in our study. It is probable that the potential publication bias (the probability to write and succeed in publishing a study) has increased the prevalence of FD with malignant transformation and may explain the difference in the higher prevalence of malignant transformation in our study.…”

Section: Discussioncontrasting

confidence: 75%

“…Though some researchers claim that FD has a characteristic appearance in MRI, there are also reports indicating that the diagnosis may only be confirmed after a biopsy [4][5][6][7]. The estimated prevalence of malignant transformation in FD ranges from 0.4 to 6.7% [8]. In radiographs, FD-related malignancies have been described as mineralized, poorly marginalized osteolytic lesions with cortical destruction, though these characteristics may also be present in a benign FD lesion [8].…”

Section: Introductionmentioning

confidence: 99%

“…The estimated prevalence of malignant transformation in FD ranges from 0.4 to 6.7% [8]. In radiographs, FD-related malignancies have been described as mineralized, poorly marginalized osteolytic lesions with cortical destruction, though these characteristics may also be present in a benign FD lesion [8]. Due to the increasing popularity of MR imaging, the MRI characteristics of FD should be more familiar to radiologists [9].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Magnetic resonance imaging characteristics in patients with histopathologically proven fibrous dysplasia—a systematic review

2020

View full text Add to dashboard Cite

Objective To examine the demographics, lesion location, and characteristic magnetic resonance imaging (MRI) findings in patients with histopathologically proven fibrous dysplasia (FD). Materials and methods A systematic literature search of the MRI findings in patients with histologically proven FD was performed. Altogether, 76 articles with 136 patients were evaluated. Results The mean age of the patients was 35.0 + − 18.5 years (range 1 month-75 years). Fifty-eight of the cases were females, 51 males, and in 27 gender was not defined. The most common locations were craniofacial (n = 55 (40%)), long bones (n = 31 (23%)), and spine (n = 24 (18%)). The monostotic form of FD was the most common. Signal intensities (SI) on T1-weighted images were predominantly hypointense (n = 46 (37%)). The SI was highly variable on T2-weighted images with hyperintensity being most common (n = 22 (18%)). Contrast enhancement was found in 75 (55%) FD patients. Secondary aneurysmal bone cysts (ABCs) and malignant transformation in patients without prior radiotherapy was found in some patients. Conclusion Current knowledge of the MRI findings in patients with FD is based mainly on case reports. SI in patients with FD is variable and contrast enhancement is common. FD may explain etiology of spinal bone tumor in some patients. FD with malignant transformation should be considered also in patients without prior radiotherapy. Further studies are needed to clarify if FD displays specific characteristics allowing it to be distinguished from other bone tumors.

show abstract

Section: Discussioncontrasting

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Magnetic resonance imaging characteristics in patients with histopathologically proven fibrous dysplasia—a systematic review

2020

View full text Add to dashboard Cite

show abstract

“…A malignant transformation of FD is rare, which occurs less than 1% of cases [19, 20]. In present study, the clinicians performed biopsy or surgery for 13 of the patients.…”

Section: Discussionmentioning

confidence: 92%

The value of 99mTc-methylene diphosphonate single photon emission computed tomography/computed tomography in diagnosis of fibrous dysplasia

Zhang

et al. 2017

BMC Med Imaging

View full text Add to dashboard Cite

BackgroundFibrous dysplasia (FD) is a rare benign bone disorder in which the normal bone is replaced by immature fibro-osseous tissue. However, some case reports have reported that FD showed significantly increased 99mTc-methylene diphosphonate (99mTc-MDP) uptake on whole-body bone scintigraphy (WBS), which may mimic bone metastasis or skeletal involvement of the patients with known cancer. Thus, the purpose of present study is to observe the reliable characteristics and usefulness of single photon emission computed tomography/computed tomography (SPECT/CT) for the diagnosis of FD.MethodsThis was a retrospective review of 21 patients with FD (14 males and 7 females, mean age 51.2 ± 12.5 years) who were referred to have WBS to determine whether there was any osseous metastasis. WBS and SPECT/CT images were independently interpreted by two experienced nuclear medicine physician together with a diagnostic radiologist. In cases of discrepancy, consensus was obtained by a joint reading. The final diagnosis was based on biopsy proof and radiologic follow-up over at least 1 year.ResultsThe lesions of FD were most frequently found in craniofacial region (15/21). Eighteen of the 21 (85.7%) cases showed moderate and high metabolism on WBS (compared to sternum). On CT imaging, GGO and expansion were the most common finding, were noted in 90.5% and 85.7% of the patients. Lytic lesions were present in 61.9% of the patients, and sclerosis was present in 38.1% of the patients. Cortical disruption was not seen in any patient.ConclusionsFD has certain characteristic appearance on SPECT/CT. It should be enrolled in the differential diagnoses when lesions show elevated 99mTc-MDP uptake on WBS. For SPECT/CT, the CT features of GGO and expansion in the areas of abnormal radiotracer uptake are helpful for the diagnosis of FD.

show abstract

“…It is a useful imaging modality for detecting the distribution of lesions, and scintigraphy has been evaluated for discriminating between monostotic and polyostotic disease, ruling out metastasis of secondary sarcoma, and recurrence after therapy 33. Monostotic FD, especially in the bones of the skull, generally appears as an area of markedly increased uptake reflecting hyperemia as well as osteoid matrix, with a particularly intense homogenous uptake pattern in the delayed phase 34.…”

Section: Discussionmentioning

confidence: 99%

Fibrous dysplasia of the maxilla in an elderly female: Case report on a 14-year quiescent phase

Lee

Park

et al. 2016

Imaging Sci Dent

View full text Add to dashboard Cite

Fibrous dysplasia (FD) is an uncommon skeletal disorder in which normal bone is replaced by abnormal fibro-osseous tissue. Mainly, FD is found in children, and by adulthood it usually becomes quiescent. Our case showed FD of more than 14-year duration in the left maxilla. Our evaluation was that growth ceased in adulthood and had achieved the static stage. Because FD cases in elderly patients are rarely reported, we hereby present a monostotic FD case in a 65-year-old female. We presented sequential radiographic images and scintigraphic images of this case, and combined them with a literature review that emphasized the progression of the disease.

show abstract

Malignant Transformation in Monostotic Fibrous Dysplasia

Abstract: Supplemental Digital Content is available in the text

Cited by 60 publications

References 17 publications

Magnetic resonance imaging characteristics in patients with histopathologically proven fibrous dysplasia—a systematic review

Magnetic resonance imaging characteristics in patients with histopathologically proven fibrous dysplasia—a systematic review

The value of 99mTc-methylene diphosphonate single photon emission computed tomography/computed tomography in diagnosis of fibrous dysplasia

Fibrous dysplasia of the maxilla in an elderly female: Case report on a 14-year quiescent phase

Contact Info

Product

Resources

About