Malignant Transformation Arising From Mature Cystic Teratoma of the Ovary: A Retrospective Study of 20 Cases

Sakuma, M.; Otsuki, Takeo; Yoshinaga, Kosuke; Utsunomiya, Hiroki; Nagase, Satoru; Takano, Tadao; Niikura, Hitoshi; Itō, Kiyoshi; Otomo, Keiko; Tase, Toru; Watanabe, Yoh; Yaegashi, Nobuo

doi:10.1111/igc.0b013e3181daaf1d

Cited by 59 publications

(51 citation statements)

References 23 publications

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“…Older age ( P = 0.003), greater tumor size ( P = 0.001), higher CA125 ( P = 0.035) or CA19‐9 ( P = 0.022) were associated with MT. The median age of the MT group (49.5 years) was concordant with that in previous reports noting that the incidence of MT peaks in the range 45–60 years 3. At the same time, higher neutrophil count ( P = 0.011) and N/L ratio ( P = 0.002) were associated with MT.…”

Section: Resultssupporting

confidence: 89%

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Elevated preoperative neutrophil : lymphocyte ratio as a preoperative indicator of mature cystic teratoma with malignant transformation

Nanki

Chiyoda

Kataoka

et al. 2017

J of Obstet and Gynaecol

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AimTo examine the usefulness of the neutrophil : lymphocyte (N/L) ratio as a cost‐effective and simple diagnostic marker of mature cystic teratoma (MCT) with malignant transformation (MT).MethodsA retrospective chart review was performed between 1998 and 2013 of 12 MCT patients with MT and between 2009 and 2013 of 130 patients with benign MCT. Data were collected on age, tumor size, white blood cell count with differential counts, tumor marker levels, and presenting features.ResultsOlder age, greater tumor size, higher CA19‐9 or CA125, higher neutrophil count, and higher N/L ratio were associated with MT on univariate analysis. White blood cell count; lymphocyte count; and the tumor marker squamous cell carcinoma antigen were not associated with MT. Older age (≥median), larger tumor size (≥10 cm), and high N/L ratio (≥5.0) were predictors of MT (hazard ratio, 11.51, 5.87, and 11.11, respectively). Six of 12 patients were diagnosed with MT on preoperative magnetic resonance imaging and five of 12 had an N/L ratio ≥5.0.ConclusionsNeutrophil : lymphocyte ratio is a potential preoperative diagnostic marker of MT. The optimal cut‐off should be determined in future large‐scale studies.

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Section: Resultssupporting

confidence: 89%

“…MCT with malignant transformation (MT) is especially rare, with an occurrence of 0.17–2% 2, 3. Squamous cell carcinoma (SCC) is the major histological type of MT, accounting for 80–90% of cases.…”

Section: Introductionmentioning

confidence: 99%

Elevated preoperative neutrophil : lymphocyte ratio as a preoperative indicator of mature cystic teratoma with malignant transformation

Nanki

Chiyoda

Kataoka

et al. 2017

J of Obstet and Gynaecol

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“…Chen et al 42 reported that the survival rate in stage IA disease for oophorocystectomy/oophorectomy did not differ statistically from oophorectomy plus hysterectomy or retroperitoneal lymphadenectomy. Sakuma et al 43 performed a study on patients in stage IA, in which 5 of 8 cases were treated without retroperitoneal lymphadenectomy, and 1 case was managed with USO only. All patients survived without recurrence.…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma Arising From Mature Cystic Teratoma of the Ovary

Chiang

La²,

Peng³

et al. 2011

Int J Gynecol Cancer

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: With our review as basis, we recommend being cautious of the following risk factors: patient age, tumor size, ultrasound characteristics, sonar tumor vessel wave form, computed tomography, and levels of SCC and CA125 tumor markers. We suggest that patients have regular ovarian ultrasound examination. Based on our literature review, stage IA patients who undergo standardized operational procedures do well without adjuvant treatment, but such patients must be confirmed accurately with complete surgical staging to be in stage IA before undergoing conservative management. The optimal approach to the management of patients with advanced stage and recurrent disease is unclear. Surgical cytoreduction with proper staging, adjuvant therapy with platinum-based or paclitaxel-based chemotherapy, and concurrent whole pelvic radiation have been recommended as possible methods of treatment.

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“…The dermoid cyst, extremely rare in the testis, is the most frequent ovarian teratoma. Consequently, the squamous carcinoma accounts for more than half of all somatic malignancies reported [48,49]. Thyroid tissue is a frequent finding in benign teratoma of the ovaries but not existing in the testis, thus also thyroid cancer, generally called "struma maligna ovarii", has been described many times in the ovaries [50].…”

Section: Comparison Of Testicular and Ovarian Teratomasmentioning

confidence: 99%

Teratoma with somatic-type malignant components of the testis. A review and an update

Mikuz

Colecchia

2012

Virchows Arch

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Malignant transformation of germ cell tumors into somatic malignancy is uncommon. Its presentation differs from series to series, with 43 % of adult cases identified within the primary tumors and the remainder at the time of relapse or in the metastasis. Patients with stage I disease enjoy an excellent prognosis; whereas in metastatic sites when not completely resectable, the somatic type malignancies suffer a dismal prognosis. Radical surgery is significant for the prospects of cure and is standard chemotherapy for germ cell tumors; a transformation-oriented treatment can be effective for these patients. A deeper understanding of the biology of this phenomenon is essential for clinicians involved in such malignancies in order to permit a better control of the disease.

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Malignant Transformation Arising From Mature Cystic Teratoma of the Ovary: A Retrospective Study of 20 Cases

Abstract: The prognosis of MT is highly dependent on age, stage, and optimal cytoreduction. Adjuvant treatment has not been standardized, although our experience supports the use of combination platinum/taxane chemotherapy.

Cited by 59 publications

References 23 publications

Elevated preoperative neutrophil : lymphocyte ratio as a preoperative indicator of mature cystic teratoma with malignant transformation

Elevated preoperative neutrophil : lymphocyte ratio as a preoperative indicator of mature cystic teratoma with malignant transformation

Squamous Cell Carcinoma Arising From Mature Cystic Teratoma of the Ovary

Teratoma with somatic-type malignant components of the testis. A review and an update

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