Elevated preoperative neutrophil : lymphocyte ratio as a preoperative indicator of mature cystic teratoma with malignant transformation

Nanki, Yoshiko; Chiyoda, Tatsuyuki; Kataoka, Fumio; Nomura, Hiroyuki; Nakadaira, Naoki; Iwasa, Naomi; Hashimoto, S.; Arima, Hirokazu; Susumu, Nobuyuki; Aoki, Daisuke

doi:10.1111/jog.13271

Cited by 7 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Six studies were excluded from tabulation and analysis after reading the full text [13,[18][19][20][21][22]. Among them, three were excluded due to insufficient data [18][19][20][21]. Finally, Sagi-Dain et al…”

Section: Excluded Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Is There a Role of Elevated CA 19-9 Levels in the Evaluation of Clinical Characteristics of Mature Cystic Ovarian Teratomas? A Systematic Review and Meta-analysis

Prodromidou¹,

Pandraklakis²,

Loutradis³

et al. 2019

Cureus

View full text Add to dashboard Cite

The role of preoperative CA 19-9 levels in patients with ovarian mature cystic teratoma (MCT) and the association of elevated levels of the biomarker with patients' and tumor characteristics were evaluated. Four electronic databases were searched for articles published up to September 2019. Trials that evaluated the significance of elevated CA 19-9 in patients with ovarian MCTs and publications with > 20 patients were considered eligible for inclusion. Seven studies that included 995 patients with an ovarian MCT who were evaluated with elevated (n = 364) or normal (n = 631) CA 19-9 levels were included. Mean tumor size was significantly increased in patients with elevated CA 19-9 levels (p = 0.038). The rate of ovarian torsion was significantly increased in the elevated CA 19-9 group (p = 0.04). The present study highlights the importance of CA 19-9 as a marker in the diagnosis of MCT, and a meta-analysis supports that it could raise a high degree of clinical suspicion of early recognition of torsion and early surgical management due to complications related to increased size. Nonetheless, the diagnostic value of CA 19-9 is still limited and CA 19-9 can still serve only as a supplementary diagnostic tool in patients with MCTs.

show abstract

Section: Excluded Studiesmentioning

confidence: 99%

“…included patients with benign diseases and did not report separate outcomes for those with MCT whereas Wang et al enrolled only patients with torsion in their study group and were both excluded [13][14][15][16][17][18][19][20][21][22].…”

Section: Excluded Studiesmentioning

confidence: 99%

Is There a Role of Elevated CA 19-9 Levels in the Evaluation of Clinical Characteristics of Mature Cystic Ovarian Teratomas? A Systematic Review and Meta-analysis

Prodromidou¹,

Pandraklakis²,

Loutradis³

et al. 2019

Cureus

View full text Add to dashboard Cite

show abstract

“…SCTs can express a diversity of serum tumor markers such as elevated AFP, CEA, CA72-4, and CA19-9 [ 17 – 20 ] and these tumor markers are helpful in identifying SCT in clinical practice. Especially, the CA19-9-positive rates in immature, mature, and malignant SCTs have been reported as 57%, 57%, and 48.6%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Mucinous tumor arising in a giant sacrococcygeal teratoma

Zhang

Xiao-long²,

Zeng³

et al. 2017

Medicine

View full text Add to dashboard Cite

Rationale:Teratomas, which most frequently affect adult females, are the most common type of germ cell tumor, it always comprises derivatives of at least 2 germ layers. The most common site of primary teratomas is the ovary. Sacrococcygeal teratomas (SCTs), which are exceedingly rare in adults, are generally found in newborns or children.Patient concerns:A 39-year-old woman presented to our clinic with a 1-year history of gradually aggravated difficulty in micturition and defecation, and a tumor in her right buttock present since birth. Appropriate preoperative examinations showed a large (15.6 cm × 12.2 cm × 30.0 cm) multicystic SCT.Diagnoses:Histologic examination confirmed a mucinous tumor arising in a giant SCT.Interventions:Abdominoperineal rectal resection was performed.Outcomes:The patient recovered well and was discharged on day 33 of admission.Lessons:We report the first case of a mucinous tumor arising in an SCT, in which the teratoma presented mature tissue elements derived only from the endodermal germ layer (keratinous debris).

show abstract

“…We can only depend on some risk factors as follow: i) postmenopausal age; ii) diameter more than 10cm or growing rapidly; iii) elevated serum tumor markers especially SCC antigen and CA125; iv) the presence of a solid component that extends transmurally and invades the adjacent structures in magnetic resonance imaging (MRI). [1,3,[5][6][7] Cases with these factors usually had a worse prognosis. [4] Our patient is a postmenopausal woman with a 142*115mm mass and mildly elevated the level of tumor markers.…”

Section: Risk Factors Of Malignant Transformation In Omctsmentioning

confidence: 99%

Recurrence of ovarian squamous cell carcinoma with MET gene copy number variation: a case report and review of literature

Dong

Yuan

Yao

2020

Preprint

View full text Add to dashboard Cite

Background: Malignant transformation such as ovarian squamous cell carcinoma (SCC) in ovarian mature cystic teratoma (OMCT) is a rare tumor. The gene mutation of ovarian SCC remains unclear. We herein report a recurrent case of ovarian squamous cell carcinoma with MET gene copy number variation. Case presentation: A 60-year-old woman presented with recurrence of ovarian SCC 8 months after primary surgery. Adhesiolysis, right abdominal wall mass excision, prosthetics, enterectomy, enterostomy and partial cystectomy were performed by laparoscope. Pathologic examination demonstrated metastatic squamous cell carcinoma in ileocecus, rectum and abdominal wall muscle. MET gene copy number was elevated with copy number of six in this case. Postoperatively, the patient was treated with four cycles of combination chemotherapy with docetaxel and carboplatin. The patient was free of disease at 20 months’ follow-up. Conclusions: Optimal cytoreductive surgery combined with platinum-based chemotherapy is recommended currently for not only primary tumor but also recurrence. For patients with malignant transformation in OMCT, prompt diagnosis and individualized treatment are crucial for better prognosis. Increased copy number of MET may be correlated with her poor PFS and can be a potential therapeutic target for this case.

show abstract

Elevated preoperative neutrophil : lymphocyte ratio as a preoperative indicator of mature cystic teratoma with malignant transformation

Cited by 7 publications

References 21 publications

Is There a Role of Elevated CA 19-9 Levels in the Evaluation of Clinical Characteristics of Mature Cystic Ovarian Teratomas? A Systematic Review and Meta-analysis

Is There a Role of Elevated CA 19-9 Levels in the Evaluation of Clinical Characteristics of Mature Cystic Ovarian Teratomas? A Systematic Review and Meta-analysis

Mucinous tumor arising in a giant sacrococcygeal teratoma

Recurrence of ovarian squamous cell carcinoma with MET gene copy number variation: a case report and review of literature

Contact Info

Product

Resources

About