Malignant struma ovarii in an 11-year-old girl

Moayerifar, Mani; Koohmanaee, Shahin; Moayerifar, Maziar; Nakhochari, Ali Moradi; Rad, Afagh Hassanzadeh; Dalili, Setila

doi:10.1016/j.epsc.2017.09.035

Cited by 3 publications

(5 citation statements)

References 12 publications

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“…Pediatric MSO has been acknowledged in pediatric populations in the last three decades. To date, fewer than five cases of pediatric MSO have been reported [3][4][5]. Therefore, MSO can manifest across all age groups including pediatrics.…”

Section: Discussionmentioning

confidence: 99%

“…Most cases of pediatric MSO typically present with pelvic pain [3][4][5]. Other nonspecific gynecologic symptoms have also been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Other nonspecific gynecologic symptoms have also been reported. Although rare, some patients may also exhibit signs indicative of hyperthyroidism, such as weight loss, agitation, heat intolerance, tremors, and palpitations [3]. In these circumstances, nonspecific pelvic pain may follow symptoms of hyperthyroidism, warranting further investigation and imaging correlation [3].…”

Section: Discussionmentioning

confidence: 99%

“…Although rare, some patients may also exhibit signs indicative of hyperthyroidism, such as weight loss, agitation, heat intolerance, tremors, and palpitations [3]. In these circumstances, nonspecific pelvic pain may follow symptoms of hyperthyroidism, warranting further investigation and imaging correlation [3]. Therefore, any nonspecific pelvic pain with a background of hyperthyroidism should warrant further diagnostic workup to exclude the possibility of having MSO.…”

Section: Discussionmentioning

confidence: 99%

“…It typically exhibits a benign nature, with only 10% of cases reported as malignant struma ovarii (MSO), most commonly presenting as papillary thyroid carcinoma [2]. Despite being recognized in adults, pediatric MSO has never been acknowledged up until recently [3][4][5]. The signs and symptoms of MSO are varied and nonspecific, typically including abdominal pain and discomfort, abnormal vaginal bleeding, and menstrual irregularities [6].…”

Section: Introductionmentioning

confidence: 99%

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Thyroid Carcinoma Arising From Struma Ovarii at Adolescence: A Challenging Case With Favorable Outcome

Al-Shammaa,

Abdlkadir,

Al-Adhami

et al. 2023

Cureus

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Malignant struma ovarii (MSO) is a rare and aggressive ovarian tumor that mostly affects adults but can occur in adolescents. Prompt recognition, accurate diagnosis, and multidisciplinary management are essential for favorable outcomes. Herein, we report the youngest case of an 11-year-old girl with a large MSO. First, conventional imaging revealed a large left ovarian mass, leading to a left oophorectomy. Subsequently, histopathological examination confirmed papillary thyroid carcinoma within MSO. Thyroid and fertility-preserving surgery were chosen after multidisciplinary consultation. Despite challenges, the patient had a positive outcome with no recurrence after 36 months. Therefore, the adoption of less invasive surgical approaches and vigilant follow-up can achieve remission, but more research is needed to further enhance our understanding of the disease's risk stratification and optimal treatment strategies.

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Section: Discussionmentioning

confidence: 99%

“…Most cases of pediatric MSO typically present with pelvic pain [3][4][5]. Other nonspecific gynecologic symptoms have also been reported.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Thyroid Carcinoma Arising From Struma Ovarii at Adolescence: A Challenging Case With Favorable Outcome

Al-Shammaa,

Abdlkadir,

Al-Adhami

et al. 2023

Cureus

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Struma ovarii with atypical features and synchronous primary thyroid cancer: a case report and review of the literature

Siegel

Wolsky

Alvarez

et al. 2019

Arch Gynecol Obstet

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Malignant struma ovarii: From case to analysis

Ayhan

Kılıç

Ersak

et al. 2021

J of Obstet and Gynaecol

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Aim: To evaluate the clinico-pathologic features, treatment options, prognostic factors, and survival outcomes of malignant struma ovarii based on a systematic literature review in association with our case study. Methods: A systematic review of the medical literature was performed to identify articles about malignant struma ovarii from January 1983 until July 2020. We evaluated 178 cases. Results: The 5-year progression-free survival (PFS) and overall survival (OS) of the entire cohort was 72.5% and 91%, respectively. In univariate analysis, younger age (<43 years), whole strumal cyst diameter >95 mm, presence of a histologic type other than papillary classic-type thyroid carcinoma within the tumor and lymphovascular space invasion were related to poor PFS. Patients who received radioactive iodine ablation (RIA) before the treatment failure had significantly higher PFS than those who did not receive RIA (94.9% vs. 64.8%, p = 0.041, respectively). In univariate analysis, PFS was significantly higher in patients who underwent gynecologic surgery followed by thyroidectomy and RIA compared with those who had surgical treatment only (94.5% vs. 64.3%, p = 0.05, respectively). However, this result could not be identified as an independent prognostic factor in multivariate analysis (p = 0.207). Younger age and absence of capsular involvement were related to significantly increased OS. Histologic type was the only independent prognostic factor for PFS (hazard ratio: 3.30, 95% confidence interval: 1.122-9.748; p = 0.030) Conclusion: The most common histologic subtype was the papillary classic type. The presence of a histologic type other than the classic papillary thyroid carcinoma within the tumor was an independent adverse prognostic factor.

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Malignant struma ovarii in an 11-year-old girl

Cited by 3 publications

References 12 publications

Thyroid Carcinoma Arising From Struma Ovarii at Adolescence: A Challenging Case With Favorable Outcome

Thyroid Carcinoma Arising From Struma Ovarii at Adolescence: A Challenging Case With Favorable Outcome

Struma ovarii with atypical features and synchronous primary thyroid cancer: a case report and review of the literature

Malignant struma ovarii: From case to analysis

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