Our results showed that serum ACE levels were increased in OC patients. Being an important component of RAS, circulating ACE might be associated with ongoing pathobiologic events in ovarian carcinogenesis. Therefore, targeting the RAS pathway could provide a future treatment strategy for this cancer type.

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Aim: To evaluate the clinico-pathologic features, treatment options, prognostic factors, and survival outcomes of malignant struma ovarii based on a systematic literature review in association with our case study. Methods: A systematic review of the medical literature was performed to identify articles about malignant struma ovarii from January 1983 until July 2020. We evaluated 178 cases. Results: The 5-year progression-free survival (PFS) and overall survival (OS) of the entire cohort was 72.5% and 91%, respectively. In univariate analysis, younger age (<43 years), whole strumal cyst diameter >95 mm, presence of a histologic type other than papillary classic-type thyroid carcinoma within the tumor and lymphovascular space invasion were related to poor PFS. Patients who received radioactive iodine ablation (RIA) before the treatment failure had significantly higher PFS than those who did not receive RIA (94.9% vs. 64.8%, p = 0.041, respectively). In univariate analysis, PFS was significantly higher in patients who underwent gynecologic surgery followed by thyroidectomy and RIA compared with those who had surgical treatment only (94.5% vs. 64.3%, p = 0.05, respectively). However, this result could not be identified as an independent prognostic factor in multivariate analysis (p = 0.207). Younger age and absence of capsular involvement were related to significantly increased OS. Histologic type was the only independent prognostic factor for PFS (hazard ratio: 3.30, 95% confidence interval: 1.122-9.748; p = 0.030) Conclusion: The most common histologic subtype was the papillary classic type. The presence of a histologic type other than the classic papillary thyroid carcinoma within the tumor was an independent adverse prognostic factor.

Background: Sperm-associated antigen 9 (SPAG9) has been recently proposed as a novel biomarker for early diagnosis of several human tumors, including ovarian, cervical and breast cancers. Its clinical value remains to be clarified for endometrial cancer (EC). In this study, we investigated the utility of serum SPAG9 levels in diagnosis of EC and its association with important clinicopathological parameters.

Amaç: Sezaryen ile doğumun postpartum depresyona ve maternal bağlanmaya etkisini incelemek. Gereç ve Yöntem: Sezaryen doğum yapan 90 kadın ve vajinal doğum yapan 90 kadın çalışmaya dahil edilmiştir. Tüm kadınlara postpartum 2. haftada depresif belirtilerinin taranması için Edinburg Doğum Sonrası Depresyon Ölçeği, maternal bağlanmanın değerlendirilmesi için ise Maternal Bağlanma Ölçeği uygulanmıştır. Bulgular: İki grup arasında Edinburg Doğum Sonrası Depresyon Ölçeği ve Maternal Bağlanma Ölçeği ortalama puanları açısından istatistiksel olarak anlamlı bir fark yoktu. Ayrıca gruplardaki postpartum depresyon gelişimi için riskli olabilecek puanlara (Edinburg Doğum Sonrası Depresyon Ölçeği puanı >12 olanlar) sahip kadın sıklığı da benzerdi. Sonuç: Sezaryen ile doğumun postpartum depresyona ve maternal bağlanmaya etkisi yoktur. Anahtar Sözcükler: Depresyon; doğum sonrası; sezaryen.Introduction: To examine the effect of cesarean section on postpartum depression and maternal attachment. Methods: 90 women who delivered by cesarean section and 90 women who delivered vaginally were included in the study. The Edinburgh Postpartum Depression Scale was used to screen depressive symptoms and the Maternal Attachment Scale was used to assess maternal attachment at the 2nd postpartum week for all women. Abstract P ostpartum periodda kadınlarda biyolojik olduğu kadar psikolojik ve sosyal değişiklikler de meydana gelmektedir. Bu değişiklikler yeni anne olmuş kadınlarda bazı psikolojik rahatsızlıklara neden olabilir. Postpartum depresyon bu psikolojik bozukluklardan bir tanesidir ve doğum yapmış kadınlarda ortalama %10-15 oranında görülmektedir. [1] Hatta 40 ülkeden yapılmış 143 tane çalışmayı içeren bir derlemede bu oranın %60'lara kadar çıkabileceği rapor edilmiştir. [2]