Malignant Seminoma with Metastasis, Sertoli Cell Tumor, and Pheochromocytoma in a Spotted Dolphin (<i>Stenella frontalis</i>) and Malignant Seminoma with Metastasis in a Bottlenose Dolphin (<i>Tursiops truncatus</i>)

Estep, J. S.; Baumgartner, Ruth; Townsend, Forrest I.; Pabst, D. Ann; McLellan, William A.; Friedlaender, Ari S.; Dunn, Dale G.; Lipscomb, T. P.

doi:10.1354/vp.42-3-357

Cited by 13 publications

(11 citation statements)

References 7 publications

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“…27 A stranded spotted dolphin was found to have metastatic testicular seminoma, adrenal pheochromocytoma, and a Sertoli cell tumor; there was no data on SDHB immunohistochemistry. 28 Our observations and these reports suggest that seminoma may be an infrequent component of the SDH tumor syndrome, and additional studies are needed to further explore this connection.…”

Section: Discussionmentioning

confidence: 60%

Mapping of Succinate Dehydrogenase Losses in 2258 Epithelial Neoplasms

Miettinen

Sarlomo-Rikala

McCue

et al. 2014

Applied Immunohistochemistry &Amp; Molecular Morphology

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Losses in the succinate dehydrogenase (SDH) complex characterize 20–30% of extra-adrenal paragangliomas and 7–8% of gastric GISTs, and rare renal cell carcinomas. This loss is reflected as lack of the normally ubiquitous immunohistochemical expression of the SDH subunit B (SDHB). In paragangliomas, SDHB loss correlates with homozygous loss of any of the SDH subunits, typically by loss-of-function mutations. The occurrence of SDHB losses in other epithelial malignancies is unknown. In this study, we immunohistochemically examined 2258 epithelial, mostly malignant neoplasms including common carcinomas of all sites. Among renal cell carcinomas, SDHB loss was observed in 4 of 711 cases (0.6%) including a patient with an SDHB-deficient GIST. Histologically the SDHB-negative renal carcinomas varied. There was one clear cell carcinoma with a high nuclear grade, one papillary carcinoma type 2, one unclassified carcinoma with a glandular pattern, and one oncocytoid low-grade carcinoma as previously described for SDHB-negative renal carcinoma. None of these patients was known to have paragangliomas or had loss of SDHA expression in the tumor. Three of these patients had metastases at presentation (2 in the adrenal, one in the retroperitoneal lymph nodes). There were no cases with SDHB-loss among 64 renal oncocytomas. SDHB-losses were not seen in other carcinomas, except in one prostatic adenocarcinoma (1/57), one lymphoepithelial carcinoma of the stomach, and one (1/40) seminoma. Based on this study, SDHB-losses occur in 0.6% of renal cell carcinomas and extremely rarely in other carcinomas. Some of these renal carcinomas may be clinically aggressive. The clinical significance and molecular genetics of these SDHB-negative tumors requires further study.

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Section: Discussionmentioning

confidence: 60%

Mapping of Succinate Dehydrogenase Losses in 2258 Epithelial Neoplasms

Miettinen

Sarlomo-Rikala

McCue

et al. 2014

Applied Immunohistochemistry &Amp; Molecular Morphology

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“…by the University of Clinical signs in humans, dogs, and cats can include Illinoisʼs Zoological Pathology Program Molecular headache, hypertension, weakness and collapse, Diagnostic Laboratory and were negative. exercise intolerance, gastrointestinal distress, car-Skeletal preparation revealed that thoracic ver-diac arrhythmias, anxiety and pacing (McNiel & tebrae nine and ten were fused with complete loss Husbands, 2005), agitation, tachypnea and hyphaof the intervertebral disc spacing. The transverse ema in cats (Wimpole et al, 2010), lethargy, and and spinous processes exhibited roughening of the tachyarrhythmia and collapse in dogs (Gostelow surface with boney loss and sites of boney prolif-et al, 2013).…”

Section: Postmortem Examinationmentioning

confidence: 99%

“…Morphological differences have been found between white-beaked dolphins of the eastern and western Atlantic (Mikkelsen & Lund, 1994). The genus Lagenorhynchus is believed to be a polyphyletic taxon (Cipriano, 1997;LeDuc et al, 1999;McGowen, 2011).…”

Section: Introductionmentioning

confidence: 99%

A North Carolina Stranding of a White-Beaked Dolphin (Lagenorhynchus albirostris), Family Delphinidae:A New Southerly Record

Thayer¹,

Harms²,

Rittmaster³

et al. 2018

Aquat Mamm

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An adult 273.7-kg, 266-cm male white-beaked dolphin (Lagenorhynchus albirostris) stranded in Beaufort, North Carolina, on 16 April 2015 at 34.698125 N,-76.650476 W. Morphometrics, gross necropsy, and histopathologic evaluation were performed. Bilateral adrenal gland tumors (pheochromocytomas) were found and may have contributed to stranding. This is the first recorded white-beaked dolphin specimen to strand along the North Carolina coast, and it is the most southerly reported stranding of a white-beaked dolphin in the world.

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“…The potential for metastatic testicular neoplasia in cetaceans has been reported by Estep et al (2005). In that report, 2 cases of seminomas extended to retroperitoneal lymph nodes.…”

mentioning

confidence: 94%

“…Cowan et al (1986) and Geraci et al (1987) described 2 cases of interstitial (Leydig) cell tumor in common dolphins Delphinus delphis. Estep et al (2005) reported a seminoma with metastasis to a retroperitoneal lymph node and a Sertoli cell tumor in a spotted dolphin Stenella frontalis, in which a pheochromocytoma was concomitantly observed, and a seminoma with metastasis to the mesentery in a bottlenose dolphin.…”

mentioning

confidence: 99%