Malignant schwannoma of the sinonasal tract

Maheshwari, G. K.; Baboo, H. A.; Gopal, Usha; Baiar, D. B.; Shah, Neelam G.

doi:10.1007/bf02996845

Cited by 5 publications

(8 citation statements)

References 12 publications

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“…This too is rare having been described in probably fewer than 100 cases. 5 The presence of signi cant Bence Jones proteinuria in our case suggested multiple myeloma. Amyloidosis frequently presents with head and neck symptoms and is characterized by the deposition of insoluble proteinaceous material which has typical staining properties with Congo Red displaying apple green birefringence when viewed under polarized light.…”

Section: Discussionmentioning

confidence: 52%

Stridor: unusual presentation of multiple myeloma

2003

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We present a patient with multiple myeloma whose only presenting symptom was stridor caused by a subglottic stenosis. Biopsy suggested the presence of amyloid which prompted immunological investigations that showed hypogammaglobulinaemia and the presence of Bence Jones proteinuria at 0.93 g/24 hours. Further investigation demonstrated a 15 per cent plasma cell infiltrate into the bone marrow and a lytic lesion in the mid-shaft of the right femur. Chemotherapy and localized radiotherapy were commenced. This is a most unusual presentation of multiple myeloma and shows that immunoglobulin profiles should be properly investigated in such cases.

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Section: Discussionmentioning

confidence: 52%

Stridor: unusual presentation of multiple myeloma

2003

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“…Head and neck schwannomas rarely occur in the sinonasal cavities, and they are typically described as solitary encapsulated lesions confined to the nasoethmoid region. [1][2][3][4][5][13][14][15][16][17] The less common cellular schwannoma has been described in the sinonasal tract, and the lack of encapsulation along with bony erosion of this variant was previously noted. 11,16 Although schwannomas are uncommon in this location, and cellular schwannomas even more so, the recognition of this entity in this anatomical site is important.…”

Section: Discussionmentioning

confidence: 99%

“…11,16 Although schwannomas are uncommon in this location, and cellular schwannomas even more so, the recognition of this entity in this anatomical site is important. [1][2][3][4][5][13][14][15][16][17] The reported case reiterates the potential risk of rendering a malignant diagnosis on biopsy, particularly in light of the aggressive radiographic findings. Although bone erosion is well described in cellular schwannomas at a variety of anatomical locations, it appears that those arising in this anatomical site tend to have the additional aggressive feature of being nonencapsulated with an infiltrative growth pattern.…”

Section: Discussionmentioning

confidence: 99%

Atypical Presentation of Sinonasal Cellular Schwannoma: A Nonsolitary Mass with Osseous, Orbital, and Intracranial Invasion

et al. 2014

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Objective Sinonasal cellular schwannoma represents < 4% of head and neck schwannomas. These benign tumors are typically confined to the nasal cavity or ethmoid sinus. We describe an atypical case of sinonasal cellular schwannoma with diffuse paranasal sinus involvement and both intraorbital and intracranial extension. Results A 62-year-old woman presented with a 6-month history of right orbital proptosis and right-sided headache. Subsequent imaging revealed an invasive paranasal sinus mass extending through the skull base and displacing the right orbit. Preoperative biopsies were not diagnostic but revealed a spindle cell lesion suspicious for malignancy based on lack of encapsulation, infiltration of the sinonasal submucosa, and osseous invasion. The patient underwent open skull base surgery, and pathology confirmed a S100-positive nonencapsulated cellular schwannoma. Conclusion An atypical case of sinonasal cellular schwannoma with intracranial extension is reported. Its presentation is contrary to the common view that these are isolated solitary lesions of the nasoethmoid region. We suggest that sinonasal cellular schwannoma be considered in the differential diagnosis of a poorly defined invasive paranasal sinus mass, particularly following biopsy.

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“…Although the patient refused PET-CT to rule out a metastasis, he agreed to a biopsy of the neoplasm in his right lung, and the pathological result was a squamous carcinoma instead of a schwannoma. Schwannomas rarely metastasize to regional lymph nodes, and distant metastases are infrequent [23]. The literature has reported that distant metastases might involve the lungs, and they are associated with intracranial invasion [24].…”

Section: Discussionmentioning

confidence: 99%

“…In cases in which erosion of the osseous walls is shown by CT or MRI, schwannomas could give the wrong impression of invasive malignant tumors. Actually, they are generally benign and hardly ever undergo malignant changes [7,8]. Most cases of schwannomas occur between the 2nd and 5th decade of life and have no gender or race predilection.…”

Section: Discussionmentioning

confidence: 99%

Schwannoma of the Sinonasal Tract and the Pterygopalatine Fossa with or without Intracranial Extension

Zhou¹,

Xing

Gao³

et al. 2015

ORL

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Aims: Compared with those in other head and neck regions, schwannomas in the nasal cavity or paranasal sinuses are rare. The aim of this study was to present the experience of the authors in 11 schwannoma cases of the sinonasal tract and pterygopalatine fossa over a decade. Methods: A retrospective study from 2003 to 2014. Results: Three female and 8 male patients from 22 to 61 years of age (mean age 42 years) were admitted. The most common complaints were unilateral nasal congestion. A total of 10 of the patients received surgery, including 6 functional endoscopic sinus surgeries (FESS). The postoperative course was generally uneventful. Among the patients, 10 remained regionally asymptomatic, and there has been no clinical or radiological evidence of recurrence or residual tumor. Conclusion: Surgical treatment is effective for schwannomas of the sinonasal tract and the pterygopalatine fossa with a low recurrence rate. Conducting CT and MRI (particularly fluid-attenuated inversion recovery) before surgery is mandatory. FESS could become the primary treatment of choice.

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Malignant schwannoma of the sinonasal tract

Cited by 5 publications

References 12 publications

Stridor: unusual presentation of multiple myeloma

Stridor: unusual presentation of multiple myeloma

Atypical Presentation of Sinonasal Cellular Schwannoma: A Nonsolitary Mass with Osseous, Orbital, and Intracranial Invasion

Schwannoma of the Sinonasal Tract and the Pterygopalatine Fossa with or without Intracranial Extension

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