Atypical Presentation of Sinonasal Cellular Schwannoma: A Nonsolitary Mass with Osseous, Orbital, and Intracranial Invasion

Gencarelli, John R.; Rourke, Ryan; Ross, Tracy; Gravel, Denis; Purgina, Bibianna; Jordan, David R.; Agbi, Charles; Kilty, Shaun

doi:10.1055/s-0034-1376424

Cited by 15 publications

(10 citation statements)

References 13 publications

(29 reference statements)

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“…Typical is positivity for S100, even if these results do not differentiate between a benign and malignant neoformation [20]. The distinction between benign and malignant schwannoma is evident only with absent or scarce mitotic activity and the lack of necrosis, significant cellular atypia and infiltrative aspects seen with microscopic examination [21]; instead the lack of encapsulation is not a pathognomonic feature of malignancy. Moreover, local bone remodeling without infiltration is typical of schwannoma, particularly in the oro-sinusal region; in fact, in this case an orbital wall thinning was present, without infiltration of the right orbit.…”

Section: Discussionmentioning

confidence: 99%

Cystic Schwannoma of the Maxillary Sinus: Clinical and Radiological Findings

et al. 2018

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Schwannomas are common tumors of the nerve sheath that frequently involve the peripheral nerves of the head and neck. This benign slow-growing neoplasm is composed of nerve-supporting cells, and rarely affects the paranasal sinuses. This lesion usually occurs in the middle-aged patients, with an equal sex distribution. Schwannomas are usually solid tumors, although cystic components are rarely seen in head and neck area. MRI can prompt the diagnosis that however relies on histological examination. The present study reports a case of schwannoma of the maxillary sinus, diagnosed in a 38-year-old woman that presented nasal obstruction, pain in the right facial area and hypoesthesia in the area of right infraorbital nerve for past six months. Clinical presentation, radiologic aspects, histological features and treatment of this tumor were reported.

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Section: Discussionmentioning

confidence: 99%

Cystic Schwannoma of the Maxillary Sinus: Clinical and Radiological Findings

et al. 2018

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“…Immunohistochemistry staining plays an important role in accurate diagnosis. Sinonasal schwannomas demonstrate intense, diffuse S-100 protein immunoreactivity [14] [15]. These tumors may also demonstrate positive staining for neuron-specific enolase and vimentin and negative staining for epithelial membrane antigen (EMA), glial fibrillary acidic protein, and CD56 [3].…”

Section: Discussionmentioning

confidence: 99%

Sinonasal Schwannoma: A Case Report and Updated Review of the Literature

Takahashi¹,

Hull²,

Stevens³

et al. 2015

OJMI

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Sinonasal schwannomas are rare, benign and slow-growing peripheral nerve sheath tumors without age, race, or gender predilection. We present the unusual case of a 59-year-old female who presented with right-sided retro-orbital pressure and rhinorrhea. Radiographic imaging revealed a mass centered in the right superior nasal cavity with extension through the cribriform plate into the right more than the left subfrontal region. Biopsy confirmed the diagnosis of a sinonasal schwannoma, which was resected via nasal endoscopic surgery and ethmoidectomy. These tumors, albeit rare, should be considered in the differential diagnosis for patients presenting with a paranasal sinus mass to ensure inclusion of this benign lesion and avoid unnecessary aggressive intervention.

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“…These tumors occur in the head and neck in up to 45% of cases, and most commonly develop from the eighth cranial nerve [1]. In 4% of cases, schwanommas occur in the nose and paranasal sinuses [2]. They are found more frequently in the ethmoid and maxillary sinuses compared to the sphenoid sinus or the nasal cavity.…”

Section: Introductionmentioning

confidence: 99%

Endoscopic resection of nasal schwanomma as a diagnostic and therapeutic adjunct in the treatment of a rare disorder: A case report with literature review

Surapaneni

Hanly

Kadakia

et al. 2017

Acta Oto-Laryngologica Case Reports

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Isolated nasal schwannomas are rare lesions that can be difficult to diagnose due to nonspecific characteristics. We report a unique case of a patient with a polypoid mass abutting the lacrimal sac found to be a nasal schwanomma. A 66-year-old male with a history of previously resected nasal polyposis returned to the office complaining of symptoms suggestive of rhinosinusitis. Endoscopy was significant for a polypoid mass superior to the inferior turbinate. CT imaging revealed a 2 Â 1.8 Â 1.3 cm lesion in the right nasal cavity with bony erosion overlying the lacrimal sac. Following endoscopic resection, pathologic analysis revealed a nasal schwanomma based on S100 and Ki-67 staining patterns. The patient has been doing well for over 6 months without recurrence. Although rare, nasal schwanomma should be kept in the differential of any nasal mass, and endoscopic resection can serve as a useful tool in the management of this disorder.

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Atypical Presentation of Sinonasal Cellular Schwannoma: A Nonsolitary Mass with Osseous, Orbital, and Intracranial Invasion

Cited by 15 publications

References 13 publications

Cystic Schwannoma of the Maxillary Sinus: Clinical and Radiological Findings

Cystic Schwannoma of the Maxillary Sinus: Clinical and Radiological Findings

Sinonasal Schwannoma: A Case Report and Updated Review of the Literature

Endoscopic resection of nasal schwanomma as a diagnostic and therapeutic adjunct in the treatment of a rare disorder: A case report with literature review

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