Malignant potential of oral lichen planus: observations in 722 patients from India

Murti, P. R.; Daftary, D. K.; Bhonsle, R. B.; Pc, Gupta; Mehta, Fali S.; Pindborg, J. J.

doi:10.1111/j.1600-0714.1986.tb00580.x

Cited by 143 publications

(83 citation statements)

References 18 publications

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“…Since there are no universally accepted specific diagnostic criteria for OLP, the diagnostic approaches of the studies vary. Some are based on a diagnosis of OLP established solely on clinical features (Kovesi and Ban6czy, 1973, Silverman and Griffith, 1974, Murti et al, 1986, others have used microscopical criteria (Barnard et al, 1993), and yet others have included both clinical and histological criteria (Fulling, 1973;Silverman et alc, 1985b, 1991, Holmstrup et ci., 1988, Herrmann, 1992Voute et cil, 1992).…”

Section: Candidosismentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

467

461

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Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

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Section: Candidosismentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

467

461

View full text Add to dashboard Cite

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“…The prevalence of OLP in the population ranges between 0.2 % to 3.3 % in a selected Japanese population [1][2][3][4] , 2.6 % in an Indian population 5) , 0.4 % in a Malaysian population 6) , and 1.9 % in a Swedish population 7) . Microscopically, OLP is characterized by hyperkeratosis of the mucosal epithelium, hydropic degeneration of the epithelial basal layer, and a band-like infiltrate of inflammatory cells in the dermal-epidermal interface 8,9) .…”

Section: Introductionmentioning

confidence: 99%

Human Papillomavirus in Oral Lichen Planus of Japanese Patients

Kato

Kawai

Isomura

et al. 2015

J. Hard Tissue Biology.

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Oral lichen planus (OLP) can undergo malignant transformation and become squamous cell carcinoma (SCC). Oral infection with human papillomavirus (HPV) is associated with a significant risk of developing oral cancer. Although HPV DNA is detected more often in OLP tissue than in normal oral mucosa, there is as yet no firm evidence that HPV is a causative factor of malignant transformation in OLP. The objective of the present investigation was to assess HPV-genotype distribution in OLPs of Japanese patients and additionally to clarify the relationship between malignant transformation in OLP and HPV infection using PCR, in situ hybridization, and immunohistochemistry. DNA of 200 formalin-fixed, paraffin-embedded biopsy and surgical specimens of OLP was extracted. HPV infection was first detected by PCR using consensus HPV primers. Positive PCR samples were then further analyzed by PCR using HPV type-specific primers (HPV-6, -11, -16, -18 and -33). Eighty-three samples (41.5 %) out of the total 200 OLP specimens analyzed were HPV positive. In the HPV type-specific PCR assay, the most frequent type of HPV was HPV-16 (25.5 %), which is a high-risk type of HPV that is associated with malignant disorders and is often detected in SCC. The highest HPV-16 positive rate was obtained for the erosive type of OLP (28.3 %). Positive staining for HPV DNA by in situ hybridization was observed in the nuclei of cells in all layers of the epithelium in all HPV PCR positive samples. Immunohistochemically, nuclei of cells in the upper layer of the epithelium in all HPV PCR positive samples stained positive for the anti-HPV antibody. These results indicated that HPV-16 was often present in OLP of Japanese patients, especially in the erosive type of OLP, and suggested that HPV infection is a risk factor for malignant transformation in OLP lesions.

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“…It is well known that the risk of malignant transformation of oral lichen planus (OLP) remains a controversial issue (1)(2)(3)(4)(5)(6)(7)(8)(9). Krutchkoff et aI., who in 1978 critically reviewed 223 cases published between 1950 and 1976 found only 15 cases of malignant transformation of OLP, acceptable based on certain strict guidelines that they outlined (1).…”

Section: Introductionmentioning

confidence: 99%