Malignant Pleural and Peritoneal Mesothelioma Consequential to Brief Indirect Asbestos Exposure

Singhal, Bharati; Kohli, Supreethi; Singhal, Anu; Kumar, Vinod

doi:10.4103/2156-7514.135662

Cited by 4 publications

(3 citation statements)

References 8 publications

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“…Among our study population, the number of male patients was higher than females, similar to the results of the previous studies, to explain such a gender difference, it has been proposed that compared with women, men have more occupational exposure to asbestos, thereby leading to a higher incidence in males [25,26]. Different from previous studies, in our study, the elderly patients had a larger proportion of male than the adults group (58.80% vs 52.60%), while a multinational multi-center study published in 2011 suggested a prominent higher proportion of men aged 55 and below than patients over 55 (59% vs 41%) [27].The reason may be that all cases in this study were taken from the SEER database, which is only a collection of data from 18 regions in the U.S. mainland, there are some regional limitations to the results.…”

Section: Discussionsupporting

confidence: 88%

Clinical-pathological Characteristics and Prognostic Factors for Malignant Peritoneal Mesothelioma in the Elderly

Pan

Wang

Liu

et al. 2021

Preprint

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Background: Malignant peritoneal mesothelioma (MPM) is a rare disease characterized by atypical symptoms, difficult diagnosis, variable course and poor prognosis, and it develops mainly in the elderly. The authors aimed to identify the clinical-pathological characteristics, prognosis, and prognostic factors in the elderly MPM patients.Methods: From the National Cancer Institute Surveillance Epidemiology End Results (SEER) database, 1492 patients with MPM from 1975 to 2016 were selected and divided into the elderly group (≥65) and the adult group (<65). We compared the clinical-pathological characteristics and treatment methods of elderly group (N=665) and adult group (N=827). At the same time, we analyzed specific selected clinical-pathological parameters and prognostic factors for the elderly MPM patients.Results: Compared with the adult group, the elderly group had a higher percentage of male patients (P = 0.017), white patients (P = 0.043), a lower proportion of insured patients (P < 0.001), married patients (P < 0.001), patients with peritoneal tumors (P = 0.006), patients who underwent surgery (P < 0.001), and chemotherapy (P < 0.001). There was a significant difference in the differentiation grade between the two groups (P = 0.003). The elderly patients had a shorter median survival time compared with the adult patients (6 months vs 19 months). Uninsured (hazard ratio (HR): 5.187, P = 0.005), sarcomatoid type (HR: 3.913, P <0.001), poorly differentiated (HR: 3.900, P < 0.001), distant metastasis (HR: 1.735, P = 0.001), no cancer-directed surgery (HR: 1.733, P < 0.001), and no chemotherapy (HR: 1.532, P < 0.001) were independently associated with poorer prognosis of elderly MPM patients.Conclusion: Compared with the adult patients, elderly MPM patients had higher male ratio, poor differentiation and relatively conservative treatment. The cancer-specific survival (CSS) rate of elderly MPM patients was significantly lower than that of adult patients. Insurance status, histology type, differentiation grade, stage, surgery status, and chemotherapy status were all independent prognostic factors for elderly MPM patients.

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Section: Discussionsupporting

confidence: 88%

Clinical-pathological Characteristics and Prognostic Factors for Malignant Peritoneal Mesothelioma in the Elderly

Pan

Wang

Liu

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Among our study population, the number of male patients was higher than that of females, similar to the results of previous studies. To explain such a sex difference, it has been proposed that compared with women, men have more occupational exposure to asbestos, thereby leading to a higher incidence of MPM in males [22,23]. In contrast to previous studies, in our study, there was a larger proportion of males among the elderly patients than in the adult group (58.80% vs. 52.60%), while a multinational, multicentre study published in 2011 suggested a prominently higher proportion of men aged 55 and below than patients over 55 (59% vs. 41%) [24].…”

Section: Discussionmentioning

confidence: 99%

Clinical-pathological characteristics and prognostic factors for malignant peritoneal mesothelioma in the elderly

et al. 2022

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Background Malignant peritoneal mesothelioma (MPM) is a rare disease characterized by atypical symptoms, difficult diagnosis, variable course and poor prognosis, and it develops mainly in elderly individuals. The authors aimed to identify the clinical-pathological characteristics, prognosis, and prognostic factors in elderly MPM patients. Methods From the National Cancer Institute Surveillance Epidemiology End Results (SEER) database, 1492 patients with MPM from 1975 to 2016 were selected and divided into the elderly group (≥ 65) and the adult group (< 65). We compared the clinical-pathological characteristics and treatment methods of the elderly group (N = 665) and the adult group (N = 827). At the same time, we analysed specific selected clinicopathological parameters and prognostic factors for elderly MPM patients. Results Compared with the adult group, the elderly group had higher percentages of male patients (P = 0.017) and white patients (P = 0.043) and lower proportions of insured patients (P < 0.001) married patients (P < 0.001), patients with peritoneal tumours (P = 0.006) and patients who underwent surgery (P < 0.001) and chemotherapy (P < 0.001). There was a significant difference in the differentiation grade between the two groups (P = 0.003). Elderly patients had a shorter median survival time than adult patients (6 months vs. 19 months). Uninsured (hazard ratio (HR): 5.187, P = 0.005), sarcomatoid type (HR 3.913, P < 0.001), poorly differentiated (HR 3.900, P < 0.001), distant metastasis (HR 1.735, P = 0.001), no cancer-directed surgery (HR 1.733, P < 0.001), and no chemotherapy (HR 1.532, P < 0.001) were independently associated with poorer prognosis in elderly MPM patients. Conclusion Compared with adult patients, elderly MPM patients had a higher male ratio, poor differentiation and relatively conservative treatment. The cancer-specific survival (CSS) rate of elderly MPM patients was significantly lower than that of adult patients. Insurance status, histology type, differentiation grade, stage, surgery status, and chemotherapy status were all independent prognostic factors for elderly MPM patients.

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“…7,20,21 Brief or low exposures to asbestos are capable of causing mesothelioma. 22,23 . In fact, Lacourt et al 24 found a four-fold increased risk of mesothelioma at cumulative exposure levels less than 0.1 f/cc, the U.S. occupational standard.…”

Section: Mesotheliomamentioning

confidence: 99%

Asbestos in Talc and Mesothelioma: Review of the Causality Using Epidemiology

Kanarek

Liegel

2020

MRAJ

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Talcum powder has long been contaminated with asbestos fibers depending on the source of the talc. Pleural and peritoneal mesothelioma are scientifically established as caused by asbestos exposures. However, when investigating causality of mesothelioma from asbestos fibers in talcum powder, epidemiology is complicated by various methodological issues and inadequacies in existing studies. The occupational and case studies are explored in an effort to bring clarity to the issue of talcum powder usage and mesothelioma. Talc is randomly and sporadically contaminated with asbestos fibers including chrysotile, tremolite and anthophyllite. Case studies of mesothelioma victims whose only asbestos exposure was to talc, found anthophyllite, tremolite and chrysotile asbestos fibers in their tissues. Exposure to all three types of asbestos fibers increases the risk of mesothelioma. The Hill criteria of causality, which considers all aspects of toxicology, biology and epidemiology, are applied to the issue. This analysis results in compelling evidence that asbestos in talcum powder is causative for mesothelioma. Thus, precaution would dictate the avoidance of the use of talcum powders.

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Malignant Pleural and Peritoneal Mesothelioma Consequential to Brief Indirect Asbestos Exposure

Cited by 4 publications

References 8 publications

Clinical-pathological Characteristics and Prognostic Factors for Malignant Peritoneal Mesothelioma in the Elderly

Clinical-pathological Characteristics and Prognostic Factors for Malignant Peritoneal Mesothelioma in the Elderly

Clinical-pathological characteristics and prognostic factors for malignant peritoneal mesothelioma in the elderly

Asbestos in Talc and Mesothelioma: Review of the Causality Using Epidemiology

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