Malignant plasmacytoma cutis

Mikhail, G. R.

doi:10.1001/archderm.101.1.59

Cited by 9 publications

(5 citation statements)

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“…There are two categories of cutaneous plasmacytoma: primary cutaneous plasmacytoma develops without evidence of myeloma and has been associated with paraproteinemia. [9][10][11] It has been reported to progress to multiple myeloma in approximately 20% of cases, despite a negative evaluation at presentation. [11][12][13] Secondary cutaneous plasmacytoma develops in association with multiple myeloma (called "metastatic plasmacytoma"), or as a direct extension of an underlying bone lesion.…”

Section: Discussionmentioning

confidence: 99%

Case of multiple myeloma associated with extramedullary cutaneous plasmacytoma and pyoderma gangrenosum

2004

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A variety of cutaneous manifestations has been described in multiple myeloma including extramedullary cutaneous plasmacytomas, cutaneous amyloidosis, pyoderma gangrenosum, leukocytoclastic vasculitis, necrobiotic xanthogranuloma, scleromyxedema, Sweet's syndrome, subcorneal pustular dermatosis, scleredema, and plane xanthomas etc. An 89-year-old Korean man, who had been suffering from multiple myeloma 1 year previous, presented for evaluation of two nodules on the right side of the forehead, left side of the chest (7th rib area), and multiple ulcers with papulopustules on both the thigh and the left side of the chest (2nd rib area) during 15 days, which developed at the same time. A biopsy of a lesion which manifested as a cutaneous nodule on the right side of the forehead revealed dermal infiltration by well-differentiated plasma cells, similar to those found on a bone marrow biopsy, and a biopsy of the lesion manifested as a painful ulceration on the right thigh area showing dermal neutrophilic infiltration. Histologic findings were consistent with plasmacytoma and pyoderma gangrenosum, respectively. We present a case of multiple myeloma which developed extramedullary cutaneous plasmacytoma and pyoderma gangrenosum simultaneously, which is very rare. The patient was treated with a systemic steroid and conservative therapy.

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Section: Discussionmentioning

confidence: 99%

Case of multiple myeloma associated with extramedullary cutaneous plasmacytoma and pyoderma gangrenosum

2004

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“…Plasma cell granuloma (12) is also characterized by the proliferation of plasma cells, but the lesions usually develop as large nodules within the respiratory system. Cutaneous plasmacytoma without detectable multiple myeloma in the bones has recently been reported (2)(3)(4)(5)(6)(7)(8)(9). Most of these cases, however, are related to multiple myeloma.…”

Section: Discussionmentioning

confidence: 99%

“…Although cases of solitary cutaneous plasmacytoma have occasionally been reported (2)(3)(4)(5)(6)(7)(8)(9), only a few cases of multiple cutaneous plasma-By Invitation: Received and accepted for publication April 8, 1980.…”

Section: Introductionmentioning

confidence: 99%

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A Case of Plasmacytosis With Multiple Peculiar Eruptions

Kitamura¹,

Tamura

Hatano

et al. 1980

The Journal of Dermatology

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A !l2-year-old man had been in good health until he noticed painful swelling of the lymph nodes in the left occipital region in spring of 1975. Half a year later, multiple, infiltrating erythematous or nodular lesions appeared on the anterior chest and then spread over almost his entire body except for the lower extremities. These skin lesions were reddish brown to purplish brown in color, and irregular in shape and size. All of his superficial lymph nodes were palpable, and pain was felt on pressure. No other systemic symptoms were noted.Laboratory findings showed polyclonal gammopathy; total protein, 9.6g/dl; IgG, 4,900mg/dl; IgA, 590mg/dl and an increased erythrocyte sedimentation rate of 92mm/hr. A skin biopsy revealed prominent perivascular proliferation of plasma cells and follicular hyperplasia in the dermis. Lymph node biopsy also revealed proliferation of plasma cells in both the paracortical area and medulla. No neoplastic growth was recognized.These pathological findings and polyclonal hypergammaglobulinemia were consistent with reactive plasmacytosis.The patient is now under observation, and the skin lesions and systemic lymphadenopathy have not been changed.This peculiar B-cell proliferative disorder was discussed in relation to other diseases.

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“…In Krutsay's (1959) patient there was no recurrence i year after local excision. The patient reported by Mikhail, Spindler & Kelly (1970) had metastatic spread to a regional lymph node from a solitary plasmacytoma cutis. After excision of both lesions there has not been any evidence of multiple myeloma.…”

Section: Discussionmentioning

confidence: 99%

Multiple extra-medullary plasmacytomas of the skin

Stankler

Davidson

1974

Br J Dermatol

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SUMMARY Multiple plasma cell tumours of the skin may, on rare occasions, precede clinical, radiological and laboratory evidence of systemic myelomatosis. A man presented with several plasma cell tumours of the skin but with no detectable evidence of the disseminated myelomatosis to which he succumbed 16 months later. Multiple cutaneous extra‐medullary plasmacytomas should be regarded as a cutaneous expression of multiple myelomatosis.

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Malignant plasmacytoma cutis

Cited by 9 publications

References 0 publications

Case of multiple myeloma associated with extramedullary cutaneous plasmacytoma and pyoderma gangrenosum

Case of multiple myeloma associated with extramedullary cutaneous plasmacytoma and pyoderma gangrenosum

A Case of Plasmacytosis With Multiple Peculiar Eruptions

Multiple extra-medullary plasmacytomas of the skin

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