A Case of Plasmacytosis With Multiple Peculiar Eruptions

Kitamura, Keijiro; Tamura, Naotoshi; Hatano, Hitoshi; Toyama, Keisuke; Mikata, Atsuo; Watanabe, Shaw

doi:10.1111/j.1346-8138.1980.tb01981.x

Cited by 38 publications

(22 citation statements)

References 13 publications

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“…polyclonal plasma cells, predominantly on the trunk [1][2][3]. This condition has been recognized principally in Asian patients, with a few cases in whites [4][5][6][7].…”

mentioning

confidence: 96%

High ratio of IgG4-positive plasma cell infiltration in cutaneous plasmacytosis—is this a cutaneous manifestation of IgG4-related disease?

Miyagawa‐Hayashino¹,

Matsumura²,

Kawakami³

et al. 2009

Human Pathology

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Cutaneous plasmacytosis is a rare condition affecting middle-aged individuals, characterized by multiple red-brown papules and plaques over the trunk. It has been reported mainly in Japan. The condition is accompanied by polyclonal hypergammaglobulinemia and superficial lymphadenopathy. Lung or retroperitoneal involvement occurs rarely. In the present study, 3 consecutive cases of cutaneous plasmacytosis were observed histologically to have abundant infiltration of IgG4-bearing plasma cells. All 3 were associated with superficial lymphadenopathy, one with interstitial lung involvement showing ground-glass opacity on computed tomography and the others with bone marrow plasmacytosis, showing histologic evidence of more IgG4-positive plasma cells. All 3 had polyclonal hypergammaglobulinemia, one had high serum concentration of IgG4, and all had elevated serum IL-6. The ratios of IgG4+ to IgG+ plasma cells were assessed using skin biopsy specimens with pemphigus (n = 7), discoid lupus erythematosus (n = 5), and morphea (n = 2) (mean ratios, 19%, 0%, and 0%, respectively); we noted the proportion of IgG4-positive plasma cells in cutaneous plasmacytosis (mean, 48%). IgG4-related sclerosing disease is a newly recognized systemic disorder characterized by lymphoplasmacytic infiltration and fibrosis and by a high serum IgG4 level and increased IgG4-positive plasma cells in the tissues. Skin manifestations of this disorder have not been described. Although cutaneous plasmacytosis could be a chronic allergic hypersensitivity reaction, our findings raise the possibility of a relationship in pathogenesis between cutaneous plasmacytosis and IgG4-related sclerosing disease.

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“…polyclonal plasma cells, predominantly on the trunk [1][2][3]. This condition has been recognized principally in Asian patients, with a few cases in whites [4][5][6][7].…”

mentioning

confidence: 96%

High ratio of IgG4-positive plasma cell infiltration in cutaneous plasmacytosis—is this a cutaneous manifestation of IgG4-related disease?

Miyagawa‐Hayashino¹,

Matsumura²,

Kawakami³

et al. 2009

Human Pathology

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“…Cutaneous plasmacytosis is a disorder of unknown etiology, which was first described by Yashiro as a “kind of plasmacytosis” and later redefined by Kitamura et al as “cutaneous plasmacytosis” [1, 5]. Whether pure cutaneous plasmacytosis is a condition distinct from systemic involvement has been debated.…”

Section: Discussionmentioning

confidence: 99%

“…Cutaneous and systemic plasmacytosis are rare, lymphoplasmacytic disorders characterized by red-brown poorly circumscribed plaques and nodules occurring mainly on the trunk primarily in patients of Japanese descent [1, 2]. The disease can be accompanied by fever, lymphadenopathy, anemia, and a polyclonal hypergammaglobulinemia [2, 3].…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Plasmacytosis with Perineural Involvement

Brezinski¹,

Fung²,

Fazel³

2014

Case Reports in Dermatological Medicine

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Importance. Cutaneous and systemic plasmacytosis are rare conditions of unknown etiology with characteristic red-brown skin lesions and a mature polyclonal plasma cell infiltrate within the dermis. Perineural plasma cell infiltrates may be a histologic clue to the diagnosis of cutaneous plasmacytosis. Observations. Our patient had a five-year history of persistent reddish-brown plaques on the neck and trunk without systemic symptoms. Histologic examination showed dermal perivascular and perineural plasma cells with excess lambda light chain expression. Due to decreased quality of life caused by his skin lesions, he was placed on a chemotherapeutic regimen with bortezomib. Conclusions and Relevance. The patient was diagnosed with cutaneous plasmacytosis based on classic histopathology results with a recently characterized pattern of perineural involvement. Bortezomib therapy was initiated to manage his skin eruption, which has not been previously described as a treatment for this chronic condition.

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“…in 1976 and its description was further refined in the 1980s by Kitamura et al (7). To date, the majority of cutaneous and systemic plasmacytosis cases have been observed in Asian populations, and more specifically in Japanese populations; all 41 patients reported by Uhara et al (8) were Japanese.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous and systemic plasmacytosis on the face: Effective treatment of a case using thalidomide

2016

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Abstract. Cutaneous and systemic plasmacytosis is an exceedingly rare condition that is identified in Japanese individuals in particular. The present study describes the case of a patient of mainland Chinese origin who manifested with red-brown macules, papules and plaques limited to the face. Identifying a therapy for cutaneous and systemic plasmacytosis is quite difficult, however, the present patient showed a good response to low-dose thalidomide. The exact mechanism of action is not yet clear, however, we hypothesize that thalidomide may function through decreasing the secretion of interleukin-6 and affecting the growth of plasma cells.

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A Case of Plasmacytosis With Multiple Peculiar Eruptions

Cited by 38 publications

References 13 publications

High ratio of IgG4-positive plasma cell infiltration in cutaneous plasmacytosis—is this a cutaneous manifestation of IgG4-related disease?

High ratio of IgG4-positive plasma cell infiltration in cutaneous plasmacytosis—is this a cutaneous manifestation of IgG4-related disease?

Cutaneous Plasmacytosis with Perineural Involvement

Cutaneous and systemic plasmacytosis on the face: Effective treatment of a case using thalidomide

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