Malignant pilomatricoma: two new observations and review of the relevant literature

Allaoui, Mohamed; Hubert, Elie; Michels, Jean-Jacques

doi:10.5146/tjpath.2013.01205

Cited by 7 publications

(2 citation statements)

References 13 publications

(21 reference statements)

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“…Treatment should be centered on wide excision, with consideration given to MMS in cosmetically sensitive areas. For recurrent or metastatic lesions, consider the role of radiation [ 7 , 8 , 12 ]. Finally, long-term surveillance should involve screening at 6–12-month intervals given the high recurrence rates.…”

Section: Discussionmentioning

confidence: 99%

“…Both lesions have mutations in the CTNNB1 gene which affects the WNT signaling pathway and encodes B-catenin formation [ 5 ]. Some case reports describe the development of a PMXC the setting of an established pilomatrixoma supporting the latter theory, although neither have been established as fact [ 5 , 8 ]. Currently, there are no set guidelines regarding initial treatment or protocol for long-term follow-up/surveillance.…”

Section: Introductionmentioning

confidence: 99%

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Pilomatrix Carcinoma: A Benign-Mimic with Malignant Consequences – A Case Report and Review of the Current Literature

Slovacek,

Li,

Hurley

et al. 2024

Case Rep Dermatol

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Introduction: Pilomatrix carcinomas (PMXCs) are uncommon, locally aggressive tumors with high recurrence rates, metastatic potential, and fewer than 130 cases reported in the literature. Typically, they present as an unassuming, firm, dermal swelling and therefore are frequently mistaken for more common, benign masses, leading to undertreatment which can cause local invasion and metastatic spread. Diagnosis relies on excision with pathologic analysis; however once diagnosed, there are no current recommendations to guide treatment or surveillance for recurrence or metastases. Case Presentation: Here, we present a case of one of these rare tumors. Our case describes a 1.5 × 2.5 cm firm, mobile mass at the supraorbital rim in an otherwise healthy, young patient. Prior to removal, we suspected a benign pathology; however, excision proved difficult and pathologic diagnosis was consistent with PMXC. Following discussion with tumor board, decision was made to perform Mohs micrographic surgery and staging via CT scans with regular follow-up and surveillance scans. Conclusion: PMXCs are exceedingly rare diagnoses and present like many benign lesions. Therefore, we elected to document this case to encourage providers to keep these biologically aggressive tumors on their list of differential diagnoses in an unsuspecting mass, as well as to provide our own recommendations for treatment and screening for recurrence and metastatic spread.

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Section: Discussionmentioning

confidence: 99%