Giant pedunculated pilomatrix carcinoma on the upper limb: A rare clinical appearance

Sato, Sayuri; Nakamura, Yasuhiro; Shimizu, Michio; Yamada, Katsuhiro; Teramoto, Yukiko; Yamazaki, Naoya; Yamamoto, Akifumi

doi:10.1684/ejd.2014.2476

Cited by 4 publications

(5 citation statements)

References 8 publications

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“…PC is exceedingly rare cutaneous malignancy derived from the hair follicle matrix. It shows a predilection for middle aged and elderly individuals [3,4], but the cases involving the young people have also been described [5][6][7]. PC has no specific anatomic location and may arise anywhere in the body.…”

Section: Discussionmentioning

confidence: 99%

“…PC has no specific anatomic location and may arise anywhere in the body. Although it has been shown a slight predilection for the head and neck region [3,4,[8][9][10][11][12], various other sites affected have been reported to date, such as the back [3,13], chest [3,4], upper limbs [3,7,14], lower limbs [2,15], buttock [3] or vulva [5]. The origin of PC still controversial.…”

Section: Discussionmentioning

confidence: 99%

“…In both, pilomatrixoma and PC, the basaloid cells showed a nuclear and cytoplasmic expression of β-catenin [17] and in pilomatrixoma, they showed strong positivity for CD138 and CD10 [18]. Two papers [7,12] also demonstrated a reactivity for BerEP4 in PC.…”

Section: Discussionmentioning

confidence: 99%

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Pilomatrical carcinoma – a case report and review of the literature

Bartoš¹,

Kullová²

2018

Our Dermatol Online

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We report a case of an 85-year-old man, who presented with a polypoid skin tumor in the left lumbal region. Histology revealed a malignant tumor composed predominantly of pleomorphic basaloid cell population with a high mitotic and proliferative activity. This cellular component was admixed with aggregates of anuclear cells with eosinophilic cytoplasm reminiscent of "shadow" cells seen in pilomatrixoma, as well as with whorls of keratin material reminiscent of squamoid pearls. Immunohistochemically, the basaloid tumor part was positive for CD10, p120catenin and CD138 and very sporadically positive for cytokeratin 19 and BerEP4. Cytokeratin 20 was negative and epithelial membrane antigen labelled only eosinophilic squamoid structures. In some areas, numerous interspersed dentritic melanocytes strongly immunoreactive for S-100 protein were arranged singly and in larger expansile nests within basaloid tumor mass. Histopathology and immunoprofile of lesion favored a diagnosis of pilomatrical carcinoma with intratumorous melanocytic proliferation. To the best of our knowledge, only a few such cases have been described untill now.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Pilomatrical carcinoma – a case report and review of the literature

Bartoš¹,

Kullová²

2018

Our Dermatol Online

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“…Pilomatrix carcinoma is a rare, low-grade, malignant skin tumor of the hair matrix initially described in 1980 with approximately 125 cases reported in the literature [1][2][3][4]. It is related to pilomatrixoma, a common benign skin tumor.…”

Section: Introductionmentioning

confidence: 99%

“…Pilomatrix carcinoma is characterized by a slow growth, firm, mobile nodule often misdiagnosed on initial evaluation [2,5]. They typically occur in middle-aged white males in the head and neck region, although there are several reported cases arising in extremities [3,4,[6][7][8][9]. When caught early, these lesions are often treated by a dermatologist with Mohs surgery [10][11][12].…”

Section: Introductionmentioning

confidence: 99%