Malignant phyllodes tumor with associated osteosarcomatous, chondrosarcomatous, and liposarcomatous overgrowth

Phyllodes tumour with heterologous sarcomatous differentiation: Case series with literature review

“…PTs are usually solitary tumours but can be associated with other malignancies of the breast [5,6] . In particular, malignant differentiation of both the epithelial and stromal components of PTs can occur with carcinomas, invasive and in situ, arising from the epithelial component sarcomas such as chondrosarcomas, osteosarcomas and liposarcomas, can be seen in association with the stromal component of a PT [6] .…”

“…PTs can also co-exist with a distinctly separate malignant tumour in both the ipsilateral and/or contralateral breast [3] . The association of PTs with heterologous sarcomatous differentiation is a rare occurrence with only 4 previously reported cases in English literature [5–8] .…”

Malignant phyllodes tumor of the breast with heterologous osteosarcoma and chondrosarcomatous differentiation: A rare case report with imaging findings

“…The stromal cells can exhibit heterologous sarcomatous differentiation, while the epithelial component can become malignant with in situ or invasive carcinoma [14] . Heterologous differentiation in malignant phyllodes tumor of the breast is exceedingly rare, but there are a few reported cases of malignant phyllodes tumor with chondrosarcomatous or osteosarcomatous differentiation [13 , [15] , [16] – 17] , although the reporting of radiological features of such cases is even rarer [18] . Formation of bone or cartilage tissue in mammary tumors is rare, and as a primary breast tumor, osteosarcoma or chondrosarcoma may occur in 3 different forms: as a pure neoplasm (pure osteosarcoma or chondrosarcoma), as the stromal component of a histologically malignant phyllodes tumor, or as osteosarcomatous or chondrosarcomatous differentiation in a metaplastic carcinoma [19 , 20] .…”

A Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review

“… 9 Moreover, malignant PT is common with well-differentiated liposarcoma (WDL) or dedifferentiated liposarcoma (DDL), whereas malignant PT with MLP and PLP is rare. To date, only three cases of PT with mixed differentiation of sarcoma have been reported; one was malignant PT mixed with differentiation of MLP and PLP; 10 another was malignant PT mixed with differentiation of osteosarcoma, chondrosarcoma, and liposarcoma; 11 and the remaining one was malignant PT mixed with WLD and MLP. 12 In our case, malignant PT was accompanied by MLP and PLP.…”

“… Myxoid and pleomorphic liposarcoma S NA Sancheti SM 46 27/F 5 Pleomorphic liposarcoma arising in a malignant phyllodes tumor of breast: A rare occurrence. Pleomorphic liposarcoma S NA TomasD 11 71/F 3 Malignant phyllodes tumor with associated osteosarcomatous, chondrosarcomatous, and liposarcomatous overgrowth. Not specified S&R NED Lee JW 47 53/M 15 Malignant phyllodes tumor of a genotypic male, phenotypic female with liposarcomatous differentiation.…”