Malignant Phyllodes Tumor of the Breast: A Case Report

Alzoubaidi, Mohammed; Qiu, Suimin; Bonnen, Mark; Joyner, Melissa; Roehl, Kendall R.; Silva, Colleen; Chao, Celia

doi:10.2174/1876817201103010045

Cited by 9 publications

(8 citation statements)

References 15 publications

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“…This is the second case reported in Kermanshah, Iran. [1] Malignant PT represents less than 1% of all breast malignancies and commonly has an indolent clinical course with a propensity for local recurrence [9]. Abusalem et al [10] reported that in their study, the mean age of patients with borderline PT was 42 years and higher than benign (37 years) and malignant (41 years) Ts.…”

Section: Discussionmentioning

confidence: 99%

Low Grade Malignant (Borderline) Phyllodes Tumor of the Breast: Case Report and Review of Literature

Ramezani¹,

Sadeghi²

2017

JCRT

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Phyllodes tumor (PT) of the breast is a rare disease usually presents as a large lump. The aim of this study was to report low grade malignant (borderline) PT of the breast in Kermanshah, Iran. A 55-year-old lady was admitted to the surgery ward with left breast mass since 2-3 months ago. In past medical history, the patient had left breast surgery due to fibrocystic change seven years ago. Grossly her specimen consisted in a piece of gray soft tissue measuring 10*8*4.5 cm with lobulated appearance and small cystic areas. In permanent diagnosis, the pathologist reported low-grade malignant (borderline) PT. Microscopically the tumor was composed of benign glandular elements and hypercellular spindle-shaped stroma. Mitotic index was 3/10 high power field (HPF). The border was well-circumscribed with satellite lesion. In conclusion, the diagnosis of borderline phyllodes tumor cannot be made only on age, the size of tumor, imaging or clinical features. Microscopic evaluation with evaluation of stromal cellularity, atypia, mitotic counts and border of the tumor is necessary for definite diagnosis and categorizing of this tumor.

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Section: Discussionmentioning

confidence: 99%

Low Grade Malignant (Borderline) Phyllodes Tumor of the Breast: Case Report and Review of Literature

Ramezani¹,

Sadeghi²

2017

JCRT

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“…Giant MPTB can lead to the development of hypoglycemia, which results from increased insulin-like growth factor 2 levels produced by the tumor ( 15 , 16 ). Metastasis from MPTB occurs in 6.2–25% of cases ( 17 ), most frequently metastasizing to the lung, bone and liver ( 18 , 19 ).…”

Section: Discussionmentioning

confidence: 99%

Giant malignant phyllodes tumor of the breast: A rare case report and literature review

et al. 2016

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Malignant phyllodes tumor of the breast (MPTB) is rarely encountered in clinical practice. Preoperative diagnosis is challenging due to nonspecific radiological and histological features, and the prognostic factors and optimal treatment remain controversial. The current report describes the case of a middle-aged female with giant MPTB who underwent multidisciplinary intervention, including surgery, postoperative chemotherapy and radiotherapy. To date, the disease-free survival (DFS) of the patient has reached 18 months. Furthermore, a related literature review summarize the clinicopathological characteristics and treatment progress regarding MPTB is presented, along with an analysis of the indications for therapeutic strategy in the current case. In the future, multi-center clinical trials must be initiated to identify the criteria for diagnosis and optimal treatment consensus for MPTB. In conclusion, the present case highlights that multidisciplinary management may contribute to DFS following the treatment of giant MPTB.

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“…[2] Approximately 16% to 30% of phyllodes tumors are malignant [3] ; while difficult to identify, they are generally characterized by rapidly growing huge masses that may present with delayed metastases, mainly to the lung. [4] Surgery with sufficient resection margins is the standard treatment for phyllodes tumors, and adjuvant radiotherapy is recommended to reduce local recurrence. Adjuvant chemotherapy is suggested for selected patients with large, high risk, or recurrent tumors only after thorough evaluation.…”

Section: Introductionmentioning

confidence: 99%

Complete remission of giant malignant phyllodes tumor with lung metastasis

Moon¹,

Jung²,

Lee³

et al. 2019

Medicine

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Rationale: Malignant phyllodes tumors are rare breast neoplasms that are associated with a 6.2% to 25% incidence rate of distant metastasis; the lung is the most common metastatic site. To date, there is no consensus regarding the treatment of metastatic malignant phyllodes breast tumors. Patient concern: A 48-year-old woman was admitted into the breast clinic for a rapidly growing right breast tumor that was first noticed 1 month prior. Diagnosis: Core needle biopsy revealed a malignant phyllodes tumor. A chest computed tomography and positron emission tomography/CT showed metastatic lymph nodes that appeared to have spread to the right axilla, as well as multiple solitary pulmonary nodules in the right lung. Fine needle aspiration on the axillary lymph node confirmed metastasis. Interventions: A right mastectomy with axillary lymph node dissection was conducted and a thoracoabdominal flap and a split thickness skin graft were performed for the skin defect. Palliative chemotherapy with doxorubicin plus ifosfamide was performed. Outcomes: An examination conducted 3 years postsurgery showed no signs of recurrence, and the patient's overall health status was satisfactory. Lessons: As standard treatment guidelines for metastatic malignant phyllodes tumors are lacking, we opted for the aforementioned aggressive treatments that resulted in complete remission of the lung metastasis. Therefore, aggressive treatment, whenever possible, is warranted.

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Malignant Phyllodes Tumor of the Breast: A Case Report

Cited by 9 publications

References 15 publications

Low Grade Malignant (Borderline) Phyllodes Tumor of the Breast: Case Report and Review of Literature

Low Grade Malignant (Borderline) Phyllodes Tumor of the Breast: Case Report and Review of Literature

Giant malignant phyllodes tumor of the breast: A rare case report and literature review

Complete remission of giant malignant phyllodes tumor with lung metastasis

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