Malignant phyllodes tumor of prostate

López-Beltrán, Antonio; Gaeta, John F.; Huben, Robert P.; Croghan, Gary A.

doi:10.1016/0090-4295(90)80068-x

Cited by 36 publications

(26 citation statements)

References 12 publications

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“…Clinically, most patients with prostatic sarcoma suffered from urinary retention [6,7], although hematuria, dysuria, frequency, and nocturia also could occur. Prostatic sarcoma is generally considered an aggressive malignancy and it easily metastasizes to lung [8] and bone [9]. Prognosis is generally poor, with a medium survival less than 15 months and only 10% of patients surviving more than 3 years [10].…”

Section: Discussionmentioning

confidence: 99%

Prostatic Stromal Sarcoma in a Young Adult: A Case Report

Chang

Chuang

et al. 2005

Archives of Andrology

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Section: Discussionmentioning

confidence: 99%

Prostatic Stromal Sarcoma in a Young Adult: A Case Report

Chang

Chuang

et al. 2005

Archives of Andrology

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“…Phyllodes tumor is a rare neoplasm of the prostate which may undergo sarcomatous transformation, is prone to early recurrences, infiltrative growth, and has potential for extraprostatic spread. [3][4][5][6][7] Benign clinical courses have been cited, but the follow-up time has been limited. 33 In regards to the stroma, Gaudin et al 34 proposed the clinicopathologic categories of prostatic stromal proliferation of uncertain malignant potential and prostatic stromal sarcoma to differentiate these entities from other mesenchymal lesions of the prostate, using immunohistochemical staining data in conjunction with morphological criteria.…”

Section: Discussionmentioning

confidence: 99%

“…Unquestionably, the potential for sarcomatous transformation, recurrence, and infiltrative growth exists, but the frequency of these changes and their prognostic significance is unclear. [3][4][5][6][7] Little is known about the genetic abnormalities in this tumor. Oncogene activation and tumor suppressor gene inactivation are important mechanisms in the genesis, propagation, and spread of most cancers, but the role of these processes in phyllodes tumor has not been previously explored.…”

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confidence: 99%

Molecular Genetic Evidence for Different Clonal Origins of Epithelial and Stromal Components of Phyllodes Tumor of the Prostate

McCarthy

Zhang

Bostwick

et al. 2004

The American Journal of Pathology

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Phyllodes tumor of the prostate is a rare neoplasm, composed of epithelium-lined cysts and channels embedded in a variably cellular stroma. The pathogenetic relationship of the epithelium and stroma is unknown and whether each is a clonal neoplastic element is uncertain. We studied the clonality of phyllodes tumors from six patients who underwent either enucleation or transurethral resection as their initial treatment. This was followed by total prostatectomy in three of the patients. Laser-assisted microdissection was performed to extract epithelial and stromal components of phyllodes tumor from formalin-fixed, paraffinembedded tissue. Polymerase chain reaction was used to amplify genomic DNA at specific loci on chromosome 7q31 (D7S522), 8p21.3-q11.1 (D8S133, D8S137), 8p22 (D8S261), 10q23 (D10S168, D10S571), 17p13 (TP53), 16q23.2 (D16S507), 12q11-12 (D12S264), 17q (D17S855), 18p11.22-p11 (D18S53), and 22q11.2 (D22S264). In each tumor, stroma and epithelium were analyzed separately. Gel electrophoresis with autoradiography was used to detect loss of heterozygosity. All tumors showed allelic loss in one or more loci of both the epithelial and stromal components. The frequency of allelic loss in the epithelial component was 2 of 5 (40%) at D7S522, 2 of 6 (33%) at D8S133, 1 of 5 (20%) at D8S137, 3 of 6 (50%) at D8S261, 4 of 4 (100%) at D10S168, 4 of 6 (67%) at TP53, 2 of 6 (33%) at D10S571, 6 of 6 (100%) at D16S507, 1 of 5 (20%) at D12S264, 1 of 6 (17%) at D17S855, 2 of 6 (33%) at D18S53, and 2 of 5 (40%) at D22S264. The frequency of allelic loss in the stromal component was 2 of 5 (40%) at D7S522, 1 of 6 (17%) at D8S133, 2 of 5 (40%) at D8S137, 3 of 6 (50%) at Phyllodes tumor of the prostate is a rare neoplasm with poorly understood pathogenesis. Histologically, it resembles phyllodes tumor of the breast with hyperplastic epithelium-lined cysts and channels embedded in a variably cellular stroma.1,2 A variety of terms have been used to describe these lesions, including phyllodes type of atypical hyperplasia, cystosarcoma phyllodes, and prostatic cystic epithelial-stromal tumor.

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“…7 To better study the outcome, Bostwick and colleagues 2 introduced a grading system for PTP based on 5 histologic features (stromal cellularity, cytological atypia, mitotic number of figures, stroma-to-epithelium ratio and necrosis) determining a low, intermediate and high grade. They found a trend towards a higher incidence of recurrence and decreased survival in high-compared to lowgrade tumours.…”

Section: Discussionmentioning

confidence: 99%

Onset of hydronephrosis and lower urinary tract symptoms in a previously healthy young man: Phyllodes tumour of the prostate as a potential diagnosis.

Ferrari

Capitanio

Rizzo

et al. 2014

CUAJ

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Cite as: Can Urol Assoc J 2014;8(7-8):e561-3. http://dx.doi.org/10.5489/cuaj.1984 Published online August 11, 2014. AbstractWe report the case of a 50-year-old healthy man with early onset of micturition symptoms associated with an elevated total prostatespecific antigen. On physical examination, we found an enlarged prostate; a first-line ultrasound of the urinary tract revealed local disease which covered the entire small pelvis. A computed tomography scan confirmed the presence of a 12.5 × 11.0 × 9.5-cm multicystic prostatic mass, compressing the bladder and pelvic ureters, associated with right hydronephrosis. Renal function was preserved and prostatic biopsies was negative for malignant disease. The mass was completely removed through transvesical approach and histological analysis diagnosed a low-grade phyllodes tumour of the prostate. The patient was free of local recurrence and metastasis 36 months after surgery.

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Malignant phyllodes tumor of prostate

Cited by 36 publications

References 12 publications

Prostatic Stromal Sarcoma in a Young Adult: A Case Report

Prostatic Stromal Sarcoma in a Young Adult: A Case Report

Molecular Genetic Evidence for Different Clonal Origins of Epithelial and Stromal Components of Phyllodes Tumor of the Prostate

Onset of hydronephrosis and lower urinary tract symptoms in a previously healthy young man: Phyllodes tumour of the prostate as a potential diagnosis.

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