Malignant peripheral nerve sheath tumour in an unusual location of the urinary bladder: case report and review of literature

Abstract

Background Malignant peripheral nerve sheath tumour (MPNST) is a rare malignant soft tissue neoplasm of ectomesenchymal origin. They usually arise from a major or minor peripheral nerve branch or its sheath and also from somatic soft tissues. The most common sites of origin include the extremities and trunk but can sometimes arise an unusual site resulting in the demise of the patient before any intervention. Case presentation We report a case of 58-year-old male who presented with complaints of weight loss of a year duration, abdominal swelling of 10 months duration and easy fatigability of 3 weeks duration. Digital rectal examination revealed a huge firm mass 6 cm from the anal verge which was non-tender. Abdomino-pelvic ultrasound scan revealed an irregular heterogeneous mass in the posterior wall of the urinary bladder measuring 15.1cmx 14.0 cm with bilateral dilatation of the renal pelvi-calyceal system and ureters. His clinical condition continued to deteriorate while on hospital admission, and he died on the12th day of admission. Post-mortem examination showed a rough ovoid tumour mass firmly adherent to the posterior wall of the bladder with compression of both ureters. Histological and immunohistochemical analysis of the tumour revealed the diagnosis of a MPNST. The final anatomical diagnosis and cause of death was that of a malignant peripheral nerve sheath tumour of the urinary bladder with obstructive uropathy and severe sepsis. Conclusion MPNST can arise at unusual sites other than its common location in the extremities and the existence of neurofibromatosis may not be present. High index of suspicion of MPNST should be raised in rapidly growing painless tumour in and around a nerve tissue. Prompt radio-imaging with biopsy and expert immunohistochemical analysis of lesions will lead to early diagnosis and intervention. Molecular targeted therapies following surgery for MPNST should be developed to improve prognosis and patient outcomes.

Intrapelvic malignant nerve sheath tumors presenting as acute urinary retention: A case report and literature review

“…The intrapelvic area is an extremely rare location for MPNST, and only a few cases have been reported in the literature. Table 1 summarizes a recently reported intrapelvic MNST arising in the bladder wall 4,5,8–12 . Despite having a large tumor, our patient had no neurological complaints but had urinary retention due to mass compression.…”

“…Table 1 summarizes a recently reported intrapelvic MNST arising in the bladder wall. 4,5,[8][9][10][11][12] Despite having a large tumor, our patient had no neurological complaints but had urinary retention due to mass compression.…”

“…MPNSTs are a rare soft tissue sarcoma that develops from the peripheral nerve or its sheath from Schwann cells and accounts for 30% of all soft tissue sarcomas. The prevalence of MPNSTs in the general population is 0.001% 5 …”

“… 5 To date, there are few cases of MPNST originating from the pelvic area and causing urinary retention in the literature. 5 Hence, we describe our patients' clinicopathologic characteristics, including clinical follow‐up, focusing on the disease diagnosis, treatment option, and outcome.…”

“…The clinical characteristics of MPNST, such as symptoms, malignancy transformation pathway, and attributes of metastasis are widely undefined and are still under investigation 5 . To date, there are few cases of MPNST originating from the pelvic area and causing urinary retention in the literature 5 .…”