Malignant peripheral nerve sheath tumour arising de novo from ganglioneuroma

A 49-Year-Old Woman With Right Apical Thoracic Mass

“…Ganglioneuroma also has a potential for malignant behavior with several cases of transformation into neuroblastoma, and other soft tissue aggressive neoplasms were reported as well. 10,11 Because of this risk, surgical resection is preferred and can often proceed without a tissue biopsy in the setting of appropriate clinical and imaging findings.…”

Malignant peripheral nerve sheath tumour with multilineage divergent differentiation including a neuroblastic component

“…1,5 It is of note that, rarely MPNST may arise in association with ganglioneuroma or ganglioneuroblastoma (either de novo or at a site of previous radiation therapy); the clinical presentations of these exceptional tumours are quite different from those of the current case. 7,8 In summary, we have described the first case of MPNST with neuroblastic elements, in conjunction with multilineage divergent differentiation. As glial neoplasms may show neuronal or primitive neuroectodermal differentiation, given the plasticity observed in MPNST, perhaps it is surprising that neuroblastic differentiation has not previously been reported in this tumour type.…”