Malignant peripheral nerve sheath tumour of the urinary bladder in a cat

Abstract

A 14-year-old domestic shorthair cat presented with a 5-month history of urinary incontinence and inappro-priate elimination. Ultrasonography revealed a well-marginated, vascular mass of mixed echogenicity ex-tending from the dorsal wall of the urinary bladder into the lumen. Partial cystectomy was performed for re-moval of the urinary bladder mass; histopathological evaluation revealed a spindle cell neoplasm with a prominent palisading pattern. Histomorphologic features and immunohistochemical demonstration of vimentin, glial fibrillary acidic protein and S-100 protein, combined with negativity for smooth muscle actin and desmin were consistent with malignant peripheral nerve sheath tumour. This case report describes a novel location of malignant peripheral nerve sheath tumour; to the authors' knowledge, the bladder has not been described as a site of origin in the cat or any other domestic species.

Retrospective canine skin peripheral nerve sheath tumors data with emphasis on histologic, immunohistochemical and prognostic factors

“…Amid these tumors, peripheral nerve sheath tumors (PNST), commonly diagnosed in humans (Weiss & Goldblum 2001) and less frequently in domestic animals (Veazey et al 1993, Omi et al 1994, Nielsen et al 2007, Schulman et al 2009, Pavia et al 2012, Pavarini et al 2013, comprise a heterogeneous group of neoplasms with exceptionally confusing nomenclature (Gross et al 2009). …”

Malignant peripheral nerve sheath tumour with metastasis and expression of endothelial differentiation factors in a horse

“…These types of tumours are well characterized, especially as a consequence of neurofibromatosis. In veterinary species, there are rare reports of such neoplasms affecting dogs (Carmichael and Griffiths 1991;Silva et al 2007;Bergmann et al 2009), cats (Watrous et al 1999;Pavia et al 2012), cattle (Beytut 2006) and goats (Ram ırez et al 2007). In a survey of equine cutaneous neoplasia, only 1.1% were schwannomas (Sch€ oniger et al 2011).…”

Lower Urinary Tract Cancer

“…[68][69][70][71][72][73][74] Like dogs, the most common lower urinary tract tumor is TCC. [75][76][77][78][79][80] Others include various sarcomas, 75,81,82 leiomyomas, 83 lipomas, 84 and lymphoma, either as part of multicentric disease or localized to the urinary bladder. 75,77,78,85,86 Patient Evaluation Overview Signalment Older cats (median age, 10-15 years) are predisposed to urinary bladder tumors in general, but lymphoma may be seen in cats as young as 1 year of age.…”