Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review

Mullins, Brandon T.; Hackman, Trevor

doi:10.1155/2014/368920

Cited by 17 publications

(32 citation statements)

References 34 publications

(60 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Malignant peripheral nerve sheath tumors (MPNST) are highly aggressive malignant mesenchymal tumors that usually arise from peripheral nerves or cells of the peripheral nerve sheath and show variable differentiation toward one of the cellular components of the nerve sheath. MPNSTs account for approximately 5–10% of all soft tissue sarcomas, of which only approximately 8–16% occur in the head and neck region [ 41 ]. They occur mainly in adults; the age at presentation may vary widely, although the peak incidence is in the fifth decade of life.…”

Section: Sinonasal Malignanciesmentioning

confidence: 99%

“…They occur mainly in adults; the age at presentation may vary widely, although the peak incidence is in the fifth decade of life. They are commonly associated with neurofibromatosis type 1 (NF1) but can also arise through sporadic mutation [ 41 ]. The cases associated with NF1 occur in younger patients (mean patient age in the third to fourth decades).…”

Section: Sinonasal Malignanciesmentioning

confidence: 99%

See 1 more Smart Citation

Imaging Characteristics of Malignant Sinonasal Tumors

Kawaguchi

Kato

Tomita

et al. 2017

JCM

View full text Add to dashboard Cite

Malignancies of the nasal cavity and paranasal sinuses account for 1% of all malignancies and 3% of malignancies of the upper aerodigestive tract. In the sinonasal tract, nearly half of all malignancies arise in the nasal cavity, whereas most of the remaining malignancies arise in the maxillary or ethmoid sinus. Squamous cell carcinoma is the most common histological subtype of malignant tumors occurring in this area, followed by other epithelial carcinomas, lymphomas, and malignant soft tissue tumors. Although many of these tumors present with nonspecific symptoms, each tumor exhibits characteristic imaging features. Although complex anatomy and various normal variants of the sinonasal tract cause difficulty in identifying the origin and extension of large sinonasal tumors, the invasion of vital structures such as the brain, optic nerves, and internal carotid artery affects patients’ prognosis. Thus, diagnostic imaging plays a key role in predicting the histological subtype and in evaluating a tumor extension into adjacent structures. This article describes the computed tomography and magnetic resonance imaging findings for malignant sinonasal tumors.

show abstract

Section: Sinonasal Malignanciesmentioning

confidence: 99%

Section: Sinonasal Malignanciesmentioning

confidence: 99%

Imaging Characteristics of Malignant Sinonasal Tumors

Kawaguchi

Kato

Tomita

et al. 2017

JCM

View full text Add to dashboard Cite

show abstract

“…Malignant peripheral nerve sheath tumor (MPNST) is a kind of highly aggressive neoplasm originated from Schwann cells. As the name implies, MPNST develops in the peripheral nerves and scarcely affects the cranial nerves [ 1 ].The total incidence is extremely low, about 0.001 % of the population [ 2 ].About 20–30 % of MPNST are seen in patient with neurofibromatosis type 1(NF-1) [ 3 ], with mortality up to 4.6–13 % [ 4 ]. Unresectable because of adjacency to big vessel or nerve trunk, frequent recurrence and distant metastasis of this tumor can be fatal.…”

Section: Introductionmentioning

confidence: 99%

Radiological findings of malignant peripheral nerve sheath tumor: reports of six cases and review of literature

Yu¹,

Wu²,

Ye³

et al. 2016

World J Surg Onc

View full text Add to dashboard Cite

BackgroundMalignant peripheral nerve sheath tumor (MPNST) is a kind of rare neurogenic tumor. If associated with neurofibromatosis type 1, MPNST usually has a higher mortality. The aim of the article is to assess the imaging characteristics of MPNST and compare them with those of benign peripheral nerve sheath tumor (BPNST) to characterize this tumor.MethodsClinical and imaging data of six cases with MPNST and 28 cases with BPNST in our institution since 2011 were retrospectively reviewed. Thirty-three patients have available MR imaging data, and two patients of MPNST also accepted CT scan. One patient accepted CT scan only. Location, size, shape, signal or density, boundary, bone destruction, relation to adjacent nerve, contrast-enhanced features as well as some other signs were assessed and compared with statistical software. Student’s t test was used for comparison of continuous variables. Fisher’s exact test was used for analysis of nominal variable. A P value ≤0.05 was considered to be statistically significant.ResultsDifferences existed between two groups in tumor size ((7.2 ± 3.3)cm in MPNST vs. (3.8 ± 1.4)cm in BPNST), unclear margin (4/6 in MPNST vs. 1/28 in BPNST), eccentricity to the nerve (1/6 in MPNST vs. 21/28 in BPNST), intratumoral lobulation (4/6 in MPNST vs. 2/28 in BPNST), peritumoral edema (3/6 in MPNST vs. 0 in BPNST), and peripheral enhancement (4/6 in MPNST (three of five MR, one CT) vs. 4/28 in BPNST). Bone destruction was observed in one MPNST.ConclusionsMR imaging is a valuable, non-invasive modality for the diagnosis of MPNST. Peripheral enhancement with non-cystic appearance or remarkable heterogeneous enhancement may be useful for differential diagnosis. Other imaging features such as large size (over 5 cm in diameter), ill-defined margin, intratumoral lobulation, peritumoral edema, and adjacent bone destruction are also supportive of MPNST.

show abstract

“…In fewer cases, head and neck may be involved [1]. These tumors generally present as an enlarging palpable mass [8]. In our patient, MPNST was confined to the left frontal sinus area.…”

Section: Discussionmentioning

confidence: 59%

“…To the best of our knowledge, only few cases of MPNSTs involving frontal sinus have been reported. Surgery is used to treat MPNSTs of the head and neck [8]. Previous studies have noticed the role of radiotherapy as adjunctive treatment [11,12].…”

Section: -Year Old/ Malementioning

confidence: 99%

Malignant Peripheral Nerve Sheath Tumor of Frontal Sinus: A Case Report, Literature Review, and Immunohistochemical Study

Zarch¹,

Moghimi²,

Dadgarnia³

et al. 2017

Foc Sci

View full text Add to dashboard Cite

Introduction: Malignant peripheral nerve sheath tumors are rare sarcomas derived from peripheral nerves or their sheaths. Head and neck region involvement in malignant peripheral nerve sheath tumors has been reported in only 15% of cases. Case Presentation: A 45-year-old man presented to us because of left forehead area swelling. Computed tomography scan demonstrated a mass originating from left frontal sinus which was associated with bone destruction and soft tissue invasion. Post-operative histopathologic studies and immunohistochemical analysis of the lesion, confirmed «malignant peripheral nerve sheath tumor» as a diagnosis. Conclusions: This case provides evidence that, although rare, malignant peripheral nerve sheath tumors can occur in frontal sinus. Combination of microscopic and immunohistochemical analysis is required for diagnosis of MPNSTs.

show abstract

Malignant Peripheral Nerve Sheath Tumors of the Head and Neck: A Case Series and Literature Review

Cited by 17 publications

References 34 publications

Imaging Characteristics of Malignant Sinonasal Tumors

Imaging Characteristics of Malignant Sinonasal Tumors

Radiological findings of malignant peripheral nerve sheath tumor: reports of six cases and review of literature

Malignant Peripheral Nerve Sheath Tumor of Frontal Sinus: A Case Report, Literature Review, and Immunohistochemical Study

Contact Info

Product

Resources

About