Malignant Peripheral Nerve Sheath Tumor of the Oral Cavity

Ramalingam, W.V.B.S.; Nair, Satish; Mandal, Ghanashyam

doi:10.1016/j.joms.2012.05.027

Cited by 13 publications

(10 citation statements)

References 7 publications

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“…They have nonspecific histological features which makes the diagnosis highly challenging. They either arise from preexisting NF or de novo [36,37]. Up to the half of MPNST cases have a family history of NF1 [37].…”

Section: Discussionmentioning

confidence: 99%

Demographic, Clinical and Histopathological Features of Oral Neural Neoplasms: A Retrospective Study

Alotaiby

Fitzpatrick

Upadhyaya

et al. 2018

Head and Neck Pathol

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Intraoral neural neoplasms though unusual may be clinically significant. The aim of this study was to categorize and evaluate oral neural tumors in a large oral pathology biopsy service. With IRB approval, a retrospective search of all neural neoplasms of the oral cavity in the archives of the University of Florida Oral Pathology Biopsy Service spanning from 1994 to 2015 was performed. Extraoral cases as well as cases with insufficient patient information were excluded. A total of 340 out of 164,578 submitted specimens in a 22 year period (0.2%) were included with a mean age of 43.3 years (range: 6-89), and 44% male and 56% female. The most commonly affected locations were: tongue (37.5%), palate (22%), lip (19%), and gingiva (14%). The microscopic diagnoses rendered, in descending order of frequency were: neurofibromas (NFs): 123 (36%), granular cell tumor (GCT): 108 (32%), schwannomas: 61 (17%), palisaded encapsulated neuromas: 39 (11%), benign neural lesion not otherwise specified: 8 (2%), and mucosal neuroma c/w multiple endocrine neoplasia type 2B (MEN 2B): 1 (< 0.5%). Six cases of NF reported a history of neurofibromatosis Type 1 (NF 1). Four cases showed multifocal lesions. Immunohistochemical staining was performed on equivocal cases (25% of the lesions) and all were confirmed by their S-100 positivity. Intraoral neural neoplasms, though uncommon should be in the differential diagnosis of oral soft tissue entities and specific consideration to syndromal linkage is paramount as this may impact patient management.

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Section: Discussionmentioning

confidence: 99%

Demographic, Clinical and Histopathological Features of Oral Neural Neoplasms: A Retrospective Study

Alotaiby

Fitzpatrick

Upadhyaya

et al. 2018

Head and Neck Pathol

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“…MPNSTs that arise from brain parenchyma, so-called malignant intracerebral nerve sheath tumors (MINSTs), as seen in two lesions in this study (Fig. 3), are extremely rare, with only 15 cases reported in the literature (10). Schwann cells of the perivascular nerves and pluripotent mesenchymal cells are suggested as the possible tumor source (10,15).…”

Section: Discussionmentioning

confidence: 78%

“…3), are extremely rare, with only 15 cases reported in the literature (10). Schwann cells of the perivascular nerves and pluripotent mesenchymal cells are suggested as the possible tumor source (10,15). Any sites of the brain can be affected and conventional imaging findings of MINSTs are similar to those of high-grade gliomas.…”

Section: Discussionmentioning

confidence: 99%

CT, MRI, and ¹⁸F-FDG PET/CT findings of malignant peripheral nerve sheath tumor of the head and neck

et al. 2017

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Background Malignant peripheral nerve sheath tumor (MPNST) is a highly malignant tumor and rarely occurs in the head and neck. Purpose To describe the imaging features of MPNST of the head and neck. Material and Methods We retrospectively analyzed computed tomography (CT; n = 14), magnetic resonance imaging (MRI; n = 16), and F-FDG PET/CT (n = 5) imaging features of 18 MPNSTs of the head and neck in 17 patients. Special attention was paid to determine the nerve of origin from which the tumor might have arisen. Results All lesions were well-defined (n = 3) or ill-defined (n = 15) masses (mean, 6.1 cm). Lesions were at various locations but most commonly the neck (n = 8), followed by the intracranial cavity (n = 3), paranasal sinus (n = 2), and orbit (n = 2). The nerve of origin was inferred for 11 lesions: seven in the neck, two in the orbit, one in the cerebellopontine angle, and one on the parietal scalp. Attenuation, signal intensity, and enhancement pattern of the lesions on CT and MRI were non-specific. Necrosis/hemorrhage/cystic change within the lesion was considered to be present on images in 13 and bone change in nine. OnF-FDG PET/CT images, all five lesions demonstrated various hypermetabolic foci with maximum standard uptake value (SUV) from 3.2 to 14.6 (mean, 7.16 ± 4.57). Conclusion MPNSTs can arise from various locations in the head and neck. Though non-specific, a mass with an ill-defined margin along the presumed course of the cranial nerves may aid the diagnosis of MPSNT in the head and neck.

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“…It also shows the complexity of a diagnosis of rare bone tumors when based on clinical and radiographic features only. Besides, MPNST onset occurs in a peripheral nerve that may exhibit differentiation of nerve sheath elements, which is more common in the proximal extremities and stem of the nerve [4]. Although uncommon, occurrence in cranial nerves usually targets the fiftieth cranial nerve pair [1].…”

Section: Discussionmentioning

confidence: 99%

“…The recommended treatment option for MPNST is surgical excision. However, it is a difficult procedure due to poor anatomical accessibility and its probability of recurrence varies approximately between 40 and 65% in head and neck region and approximately between 40 and 68% elsewhere [4]. Surgical approaches to malignant soft tissue tumor vary based on the extent of the disease, age of the patient, and pathological findings.…”

Section: Discussionmentioning

confidence: 99%

A Rare Malignant Peripheral Nerve Sheath Tumor of the Maxilla Mimicking a Periapical Lesion

Arruda

Álvares

Silva

et al. 2016

Case Reports in Dentistry

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Malignant peripheral nerve sheath tumor is a malignant neoplasm that is rarely found in the oral cavity. About 50% of this tumor occurs in patients with neurofibromatosis type I and comprises approximately 10% of all soft tissue sarcomas of head and neck region. Intraosseous malignant peripheral nerve sheath tumor of the maxilla is rare. This article is the first to address malignant peripheral nerve sheath tumor of the maxilla presenting as a periapical radiolucency on nonvital endodontically treated teeth in the English medical literature. Surgical approaches to malignant soft tissue tumor vary based on the extent of the disease, age of the patient, and pathological findings. A rare case of intraosseous malignant peripheral nerve sheath tumor is reported in a 16-year-old woman. The patient presented clinically with a pain involving the upper left incisors region and with defined unilocular periapical radiolucency lesion involved between the upper left incisors. An incisional biopsy was made. Histological and immunohistochemical examination were positive for S-100 protein and glial fibrillary acidic protein showed that the lesion was an intraosseous malignant peripheral nerve sheath tumor of the maxilla. Nine years after the surgery, no regional recurrence was observed.

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Malignant Peripheral Nerve Sheath Tumor of the Oral Cavity

Cited by 13 publications

References 7 publications

Demographic, Clinical and Histopathological Features of Oral Neural Neoplasms: A Retrospective Study

Demographic, Clinical and Histopathological Features of Oral Neural Neoplasms: A Retrospective Study

CT, MRI, and ¹⁸F-FDG PET/CT findings of malignant peripheral nerve sheath tumor of the head and neck

A Rare Malignant Peripheral Nerve Sheath Tumor of the Maxilla Mimicking a Periapical Lesion

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Malignant Peripheral Nerve Sheath Tumor of the Oral Cavity

Cited by 13 publications

References 7 publications

Demographic, Clinical and Histopathological Features of Oral Neural Neoplasms: A Retrospective Study

Demographic, Clinical and Histopathological Features of Oral Neural Neoplasms: A Retrospective Study

CT, MRI, and 18F-FDG PET/CT findings of malignant peripheral nerve sheath tumor of the head and neck

A Rare Malignant Peripheral Nerve Sheath Tumor of the Maxilla Mimicking a Periapical Lesion

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CT, MRI, and ¹⁸F-FDG PET/CT findings of malignant peripheral nerve sheath tumor of the head and neck