Demographic, Clinical and Histopathological Features of Oral Neural Neoplasms: A Retrospective Study

Abstract

Intraoral neural neoplasms though unusual may be clinically significant. The aim of this study was to categorize and evaluate oral neural tumors in a large oral pathology biopsy service. With IRB approval, a retrospective search of all neural neoplasms of the oral cavity in the archives of the University of Florida Oral Pathology Biopsy Service spanning from 1994 to 2015 was performed. Extraoral cases as well as cases with insufficient patient information were excluded. A total of 340 out of 164,578 submitted specimens in a 22 year period (0.2%) were included with a mean age of 43.3 years (range: 6-89), and 44% male and 56% female. The most commonly affected locations were: tongue (37.5%), palate (22%), lip (19%), and gingiva (14%). The microscopic diagnoses rendered, in descending order of frequency were: neurofibromas (NFs): 123 (36%), granular cell tumor (GCT): 108 (32%), schwannomas: 61 (17%), palisaded encapsulated neuromas: 39 (11%), benign neural lesion not otherwise specified: 8 (2%), and mucosal neuroma c/w multiple endocrine neoplasia type 2B (MEN 2B): 1 (< 0.5%). Six cases of NF reported a history of neurofibromatosis Type 1 (NF 1). Four cases showed multifocal lesions. Immunohistochemical staining was performed on equivocal cases (25% of the lesions) and all were confirmed by their S-100 positivity. Intraoral neural neoplasms, though uncommon should be in the differential diagnosis of oral soft tissue entities and specific consideration to syndromal linkage is paramount as this may impact patient management.

Schwannoma of the lower lip mimicking a mucocele in children

“…1 Schwannomas tend to occur in adults between the third and fifth decades of life and do not show sex predilection. 2 Most of the lesions occur in the head and neck regions (25-40%). 3 However, despite the lips and the oral cavity are highly innervated anatomic sites, they are rarely found in these locations.…”

Solitary mucosal neuroma in the maxillary incisor gingival papilla without multiple endocrine neoplasia type 2B (MEN 2B): a case report and literature review

“…MNs usually occur in the oral cavity as a component of MEN 2B, which is a syndrome of multiple MNs, medullary thyroid carcinoma (MTC), pheochromocytoma (PCC), bumpy lips, and marfanoid habitus, although not always concurrently. Oral MNs are the most common component among these components, presenting usually at early infancy, and are most often found in the lips, tongue and buccal mucosa, other less common sites being the palate and gingiva [4,24]. When the lips are involved, the lips are diffusely enlarged (bumpy lips).…”

Tumor de células granulares: relato de caso

“…As células granulares parecem envolver ou substituir as fibras musculares (Tamiolakis et al, 2019). Além disso, a presença da hiperplasia pseudoepiteliomatosa que pode acometer 1/3 dos casos, pode induzir ao diagnóstico erróneo de carcinoma de células escamosas bem diferenciado (Alotaiby et al, 2019;Mendoza et al, 2020;Tamiolakis et al, 2019).…”