Malignant neoplasms of the sinonasal tract: report of 71 patients and literature review and analysis

Khademi, Bijan; Moradi, A R; Hoseini, Sara; Mohammadianpanah, Μohammad

doi:10.1007/s10006-009-0170-8

Cited by 100 publications

(103 citation statements)

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“…2,5,7,8,[13][14][15] Epistaksisin özellikle inverted papilloma olmak üzere neoplastik hastalıklarda en sık şi-kayet olduğu tespit edilmiştir. 4,5,7 Çalışmamızdaki 2 inverted papillomlu hastada epistaksis şikayeti tespit edilmedi.…”

Section: 13-15unclassified

Evaluation of patients with unilateral endoscopic sinus surgery

Erkul¹,

Cekin²,

Kurt³

et al. 2013

Turk Arch Otolaryngol

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Section: 13-15unclassified

Evaluation of patients with unilateral endoscopic sinus surgery

Erkul¹,

Cekin²,

Kurt³

et al. 2013

Turk Arch Otolaryngol

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“…Literature supported that the fifth edition of the AJCC staging system was inappropriate for presuming the prognosis of the disease when compared with the 1997 Union Internationale Contre de Cancer (UICC)-AICC staging system. These factors were taken into consideration when proposing a revised sixth edition [10].…”

Section: Discussionmentioning

confidence: 99%

Management of Sinonasal Tumors: Prognostic Factors and Outcomes: A 10 Year Experience at a Tertiary Care Hospital

Kazi

Awan

Junaid

et al. 2013

Indian J Otolaryngol Head Neck Surg

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Sinonasal malignancies are said to be a highly heterogeneous group of cancers, accounting for less than 1 % of all cancers and less than 3 % of all upper aerodigestive tract tumors. Originating from any histologic components of the sinonasal cavity, the histopathology of these tumors is diverse. Accordingly, treatment options vary, surgery being the mainstay in most of them. Recurrence rates differs with each histological type of tumor, dependent on various factors. In this article, we have tried to identify the prevalent characteristics of sinonasal malignancies and to outline the prognostic factors affecting the outcome. It is a retrospective study design with a total number of 102 patients. Patients diagnosed with sinonasal malignancies were included and any patient previously operated outside our institute or having received prior radiation or chemotherapy were excluded. The patients were selected over a period of 10 years, from 2000 to 2010. Data was analyzed using SPSS 17. Majority of the sinonasal tumors were squamous cell carcinomas involving the maxillary sinus. Locoregional recurrence was found to be more frequent in patients with positive neck nodes on final histopathology. Sinonasal malignancies are mostly squamous cell in variety and recurrence of these rare entities is dependent on the histological variety and the presence of positive neck nodes.Keywords Sinonasal malignancy Á Locoregional recurrence Á Squamous cell carcinoma Á Positive neck nodes Malignant lesions involving the sino-nasal tract account for 0.2-0.8 % overall and 3 % of all head and neck malignancies [1]. Approximately 55 % of these lesions are carcinomas with involvement of neck nodes in 7-15 % of the conditions. Treatment involves a wide variety of modalities, including surgery, radiotherapy, and chemotherapy, alone or in combination, however, there is still great controversy about the ideal treatment [1,2]. In 2003, the American Joint Committee on Cancer (AJCC) published the sixth edition of the sino-nasal tumor staging system [3]. This was in contrast to the fifthedition staging system of sino-nasal cancer in which the surgically resectable tumors and non-resectable tumors were all grouped together in the T4 stage [4]. As a result it was difficult to evaluate the results of surgery and a newer staging system was introduced.Despite these improvements, the fact is that there is no widely accepted staging system for tumors of the nasal cavity and ethmoid/sphenoid sinuses. The AJCC tumor stage classification only includes the maxillary sinus [5]. As obvious, this proves difficulties in tumors involving multiple sites in which the primary originating site is difficult to identify.We analysed retrospectively our 10 years experience of managing sino-nasal tumors, with a series of 63 patients.

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“…Patients with SNcs are often asymptomatic in early stages and are therefore commonly diagnosed at an advanced stage (T3-4), presenting with a large primary tumour that invades the surrounding bone structures and is associated with a high frequency of poor outcome and local failure (7). Due to their rarity, there is a lack of randomized clinical trials assessing the standard treatment options for SNcs, with no clear guidelines concerning their treatment.…”

Section: Introductionmentioning

confidence: 99%