Malignant mixed germ cell tumor of ovary: a rare case report

Tiwary, Bhawana; Sinha, Hemali Heidi; Pandey, Vivek Kumar

doi:10.5455/2320-1770.ijrcog20150450

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…These tumours are rare cancers, which are seen in 8% cases of germ cell tumours but are very aggressive in nature. 5 The Endodermal Sinus Tumour (EST) and dysgerminoma are the most common combination reported in the literature 6 and the embryonal carcinoma and immature teratoma are the rarest combination as its components. 4 Embryonal carcinoma, although very rare, but it holds the very malignant potential.…”

Section: Introductionmentioning

confidence: 99%

Malignant mixed germ cell tumours- A rare case report with unusual presentation in a 05 years old female child

Sonkar¹,

Kumar

Nagayach³

et al. 2021

IJPO

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Mixed germ cell tumours (MGCT) of the ovary are malignant neoplasms of the ovary comprising of two or more types of germ cell components. Most of the malignant MGCT consists of dysgerminoma accompanied by endodermal sinus tumours, immature teratoma or choriocarcinoma. There are only few case reports of MGCTs with different combinations of malignant components. We present a very rare case of malignant MGCT in a 05 years old female child, who presented with difficulty in defecation for 6 months, swelling over sacral region for 2 months, along with bilateral inguinal swellings and difficulty in urination for 1 week. Swelling was firm, non-mobile & non-tender measuring 6.6x5 cm. On cytology it was diagnosed as malignant germ cell tumour, which was confirmed on histology as malignant MGCT (predominantly yolk sac tumour >90% and embryonal carcinoma (<10%)), metastasizing into bilateral inguinal lymph nodes.

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Section: Introductionmentioning

confidence: 99%

Malignant mixed germ cell tumours- A rare case report with unusual presentation in a 05 years old female child

Sonkar¹,

Kumar

Nagayach³

et al. 2021

IJPO

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“…Mixed germ cell tumour is termed so, because of its characteristics of involving at least more than one type of germ cell tumours. To date, the most common combination of mixed germ cells reported is dysgerminoma and endodermal sinus tumour [1], whereas the rarest counts embryonal carcinoma and immature teratoma [2]. It is primarily found in children and adolescent.…”

Section: Introductionmentioning

confidence: 99%

Mixed Germ Cell Tumour of Ovary WTH Chemotherapy Side Effect

Biswas

Moon

Ankar

2021

JPRI

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Introduction: Mixed germ cell tumour is a very rare type of aggressive cancer, consisting of more than one type of germ cell components. The most common component reported was dysgerminoma, followed by endodermal sinus tumour, teratoma, choriocarcinoma and embryonal carcinoma respectively. This study focuses on the combination of dysgerminoma and endodermal sinus tumour (yolk sac tumour) along with the hearing loss as the side effect of chemotherapy. Clinical Findings: Pain in the lower abdomen (lump is visible and has occupied hypogastrium along with bilateral iliac region extending 2-3 cm above the umbilicus), backache, fever (100.6 °F). Later after the third chemo cycle, it was found that the patient has progressive mild hearing loss. Diagnostic Evaluation: HB= 9.7gm%, TLC= 10300/cumm, PLT= 5,49 lakhs/cumm, CA 125= 909 U/ML. Histopathology Report: Ascitic fluid along with thirteen containers containing right ovarian mass, right ovary with mass, right fallopian tube, bowel deposits as well as residual nodules and pelvic deposits were sent of which, the reports indicated mixed germ cell tumour of the ovary. Therapeutic Intervention: Packed red blood cells transfusion, Pre-chemo and post-chemo hydration, Pre-chemo and post-chemo drugs, BEP Chemotherapy (Bleomycin, Etoposide, Cisplatin). Conclusion: My patient aged 11 years old female was admitted to Gynaecology Ward No – 16, AVBRH on 27/12/2020 for the first cycle of chemotherapy with the complaints of lower abdominal pain, backache and fever. The patient was diagnosed as the case of mixed germ cell tumour, further had mild hearing loss as the side effect of chemotherapy The patient is on chemo and is advised for follow up care once a month.

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A 10-year retrospective single-center study of alpha-fetoprotein and beta-human chorionic gonadotropin in Romanian children with (para)gonadal tumors and cysts

Ataikiru

Iacob

Miron³

et al. 2021

Journal of Pediatric Endocrinology and Metabolism

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Objectives Malignant tumor is a top-ranking cause of pediatric (>1-year) mortality in America and Europe. Among pediatric tumors, germ cell tumors (GCT) and gonadal tumors rank fourth (6%) by the Surveillance, Epidemiology, and End Results (SEER) program (seer.cancer.gov). Continuous research on tumor markers harnesses their full potential in tumor detection and management. We evaluated the effectiveness of beta-human chorionic gonadotropin (β-hCG) and Alpha-fetoprotein (AFP) in Romanian children with (para)gonadal tumors and cysts, determining their accuracy in detecting malignancy, tumor-type, stage, complications, prognosis, and treatment response. Methods A 10-year retrospective study of AFP and β-hCG in 134 children with cysts and (para)gonadal tumors aged one month to 17 years was performed. Results AFP/β-hCG was unelevated in patients with cysts and nonmalignant tumors. Forty-eight/86 patients (43 GCT and 5 non-GCT) with malignant tumors had elevated AFP/β-hCG, 3/48 patients had recurrences, and 25/48 had mixed-GCT (68% had elevated AFP + β-hCG). All 30 patients with Yolk sac tumors (YST) or their components had elevated AFP. Area under the curve, sensitivity and specificity for GCT were: AFP + β-hCG- 0.828, 67.2%, 100%; AFP- 0.813, 64.1%, 100%; and β-hCG- 0.664, 32.8%, 100%. Two patients whose AFP/β-hCG levels remained elevated died. Common mixed-GCT components were YST-80% and embryonal carcinoma-72%. Thirty of 34 metastasis cases were GCT, with 26/34 patients having elevated AFP/β-hCG. Conclusions AFP/β-hCG detects malignant GCT and can determine tumor-type. GCT patients with markedly elevated AFP + β-hCG had poor prognosis, especially if recurrence or metastasis was present. Recurrence is unrelated to elevated AFP/β-hCG. The tumor components and quantity present determine AFP/β-hCG values in mixed-GCT.

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Malignant mixed germ cell tumor of ovary: a rare case report

Cited by 3 publications

References 4 publications

Malignant mixed germ cell tumours- A rare case report with unusual presentation in a 05 years old female child

Malignant mixed germ cell tumours- A rare case report with unusual presentation in a 05 years old female child

Mixed Germ Cell Tumour of Ovary WTH Chemotherapy Side Effect

A 10-year retrospective single-center study of alpha-fetoprotein and beta-human chorionic gonadotropin in Romanian children with (para)gonadal tumors and cysts

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