Malignant mesothelioma of the tunica vaginalis testis: a malignancy associated with recurrent epididymitis?

Yen, Ching-Heng; Lee, Chun-Te; Su, Chin Cheng; Lo, Hua‐Cheng

doi:10.1186/1477-7819-10-238

Cited by 30 publications

(26 citation statements)

References 35 publications

(23 reference statements)

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“…It comprises of a larger group of paratesticular malignant mesotheliomas, which comprise 0.3% to 1.4% of all MM 2. MMs of the paratesticular region commonly present as hydrocoeles and/or inguinoscrotal swellings mimicking more common lesions of this region 5 6. These tumours are most common in the 55–75-year-age group 5.…”

Section: Discussionmentioning

confidence: 99%

Primary malignant mesothelioma of the spermatic cord

Ahmed¹,

Singh

Mangal

et al. 2016

BMJ Case Reports

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Primary spermatic cord malignant mesothelioma is an extremely rare tumour with only 12 cases reported so far. It is an aggressive tumour with a high recurrence rate. A 45-year-old man presented with a slow growing right inguinal swelling for the past 1 year. Physical examination revealed a well-circumscribed, hard, non-reducible swelling palpable along the medial extent of the inguinal canal with no cough impulse. Fine-needle aspiration cytology suggested metastatic carcinoma. Contrast-enhanced CT of the thorax and abdomen did not reveal any primary. Right high inguinal orchidectomy was performed at another institution. Postoperative histopathological examination (HPE) and immunohistochemistry suggested biphasic malignant mesothelioma with resected margin positive. The patient was referred to us for revision surgery and adjuvant therapy. Postoperative course was uneventful. Currently, he is undergoing radiotherapy.Surgery is the first-line treatment. Patients should receive adjuvant radiotherapy and/or chemotherapy and long-term follow-up surveillance.

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Section: Discussionmentioning

confidence: 99%

Primary malignant mesothelioma of the spermatic cord

Ahmed¹,

Singh

Mangal

et al. 2016

BMJ Case Reports

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“…Ultrasonography revealed several nodes of different sizes. Under such circumstances, CT should be performed to stage the tumor, diagnose distant metastases and, particularly, evaluate the pathological status of the retroperitoneal lymph nodes (18). Prior to radical left inguinal orchiectomy, whole-body PET-CT was performed and revealed no evidence of local lymphadenopathy or distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

Malignant mesothelioma of the tunica vaginalis testis: A case report and literature review

Zhang

et al. 2017

mol clin onc

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Abstract. Malignant mesothelioma of the tunica vaginalis testis is an extremely rare tumor without specific clinical manifestations, mainly including hydrocele formation and a painless mass. We herein present the case of a patient with hydrocele of the left testis, without any other complaints. Tunica vaginalis subinvolution was performed, and postoperative pathological examination revealed a malignant mesothelioma arising from the left tunica vaginalis testis. Whole-body positron emission tomography-computed tomography (PET-CT) and subsequent abdominal and pelvic magnetic resonance imaging (MRI) revealed no evidence of local lymphadenopathy. Radical left orchiectomy was performed after the pathological diagnosis. The pathological examination after the second surgery demonstrated that the tumor had invaded the adjacent periorchium and spermatic cord, but there was no evidence of local lymph node metastasis. Pemetrexed and cisplatin were administered at a dose of 900 and 130 mg, respectively, on the first day of a 28-day cycle. After 6 months of therapy, the disease had not progressed on abdominal and pelvic PET-CT and MRI. The patient was still followed up in our urology outpatient clinic at the time of the present report. Although testicular hydrocele is a common and easily diagnosed condition, detailed medical history and physical examination are required. Thus, when clinicians encounter patients with testicular hydrocele, a variety of possible causes must be considered, including testicular or paratesticular tumors, even rare tumors such as mesothelioma of the tunica vaginalis testis.

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“…Ultrasonography is noninvasive and simple, and 90% accurate when used to detect testicular tumours. (9) Furthermore, it can be used for differential diagnosis to exclude: (a) epididymitis; (b) florid mesothelial hyperplasia; (c) adenomatoid tumour; (d) carcinoma of the rete testis; (e) serous papillary tumour; (f) various types of testicular germ cell tumours including seminomas, embryonal carcinomas, and intratubular germ cell tumours; (g) and pleomorphic sarcomas, (10) all of which should be considered differential diagnoses. The levels of testis tumour markers including αFP, β-HCG, and LDH can aid in the diagnosis of testicular tumours.…”

Section: Discussionmentioning

confidence: 99%