Malignant Mesothelioma of the Tunica Vaginalis Testis

Boyum, James H.; Wasserman, Neil F.

doi:10.7863/jum.2008.27.8.1249

Cited by 21 publications

(9 citation statements)

References 38 publications

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“…8 Likewise, color Doppler ultrasound may reveal the vascular characteristics of malignant mesothelioma, though its interpretation can be challenging. 9 Recently there have been case reports of obtaining a correct preoperative diagnosis via US-guided fine-needle aspiration cytology of the suspected scrotal mass. 10 None of the patients in this series received preoperative cytology.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Outcomes of Tunica Vaginalis Mesothelioma: A Case Series From the National Institutes of Health

Kim

Tanakchi

et al. 2017

Clinical Genitourinary Cancer

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OBJECTIVE To present our single-institution experience with management of seven patients with mesothelioma of the tunica vaginalis. MATERIALS AND METHODS Our institution database was queried from 2003 to 2014. Clinical, surgical and pathological features were retrospectively collected and evaluated. RESULTS Seven patients were identified with tunica vaginalis mesothelioma. Average age at the time of diagnosis was 63.6 years. Four patients presented with hydrocele, one with scrotal mass, one with inguinal mass, and one with spermatocele. Two (28.6%) patients reported possible asbestos exposure. Radical orchiectomy was performed in all patients. Two patients received adjuvant radiotherapy, one patient received both chemotherapy and radiation. All patients were followed up postoperatively with serial imaging detect for recurrence. One of 7 patients in our cohort experienced recurrence at 12 months. Our mean follow-up time on these patients is 52.2 months. CONCLUSION Previous reported cases have described poor prognosis of tunica vaginalis mesothelioma despite aggressive surgery and systemic therapy. Our single-institution experience suggests relatively good outcomes with surgery and limited adjuvant therapies. Post treatment surveillance is also imperative and should include imaging routinely within the first 2 years. Negative asbestos exposure screening during history should not eliminate clinical suspicion.

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Section: Discussionmentioning

confidence: 99%

Clinical Features and Outcomes of Tunica Vaginalis Mesothelioma: A Case Series From the National Institutes of Health

Kim

Tanakchi

et al. 2017

Clinical Genitourinary Cancer

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“…In addition to hydrocele being commonly presented, scrotal mesothelioma could be associated with an extratesticular mass with atypical sonographic features [36]. Color Doppler ultrasound might have the potential to be used to unveil the vascular characteristics of malignant mesothelioma [32,37]. However, either hypervascularity or hypovascularity in mass lesions has been described in articles, and thus color Doppler ultrasound could not be used as a definitive diagnostic tool.…”

Section: Discussionmentioning

confidence: 99%

Malignant mesothelioma of the tunica vaginalis testis: a malignancy associated with recurrent epididymitis?

Yen¹,

Lee²,

Su³

et al. 2012

World J Surg Onc

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A 53-year-old Taiwanese male had several episodes of left epididymitis with hydrocele refractory to antibiotic treatment. Partial epididymectomy plus preventive vasectomy were planned, and, incidentally, an ill-defined nodule was found lying on the tunica vaginalis near the epididymal head. The pathological diagnosis was malignant mesothelioma of the tunica vaginalis testis. Radical orchiectomy with wide excision of the hemi-scrotal wall was performed. So far, there is no evidence of recurrence after more than 3 years of follow-up. Malignant tumor should be considered in the case of recurrent epididymitis refractory to empirically effective antibiotic treatment. Although the nature of this tumor is highly fatal, the malignancy can possibly be cured by early and aggressive surgical treatment.

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“…A wide age range has been reported for this tumor, ranging between 7 and 91 years, with the mean age at diagnosis being 53.5 years (Boyum & Wasserman 2008 ; Chekol & Sun 2012 ). Only 10% of the cases occur in patients younger than 25 years old (Plas et al.…”

Section: Tunica Vaginalis Mesotheliomamentioning

confidence: 98%

The legacy of the F344 rat as a cancer bioassay model (a retrospective summary of three common F344 rat neoplasms)

Maronpot

Nyska

Foreman

et al. 2016

Critical Reviews in Toxicology

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The Fischer 344 (F344) rat was used by the National Toxicology Program (NTP) for over 5 decades for toxicity and carcinogenicity studies. However, in 2006, the NTP decided to switch to a different rat stock due largely to high background control incidences of Leydig cell tumors (LCTs) and mononuclear cell leukemia (MNCL), also known as large granular lymphocytic (LGL) leukemia. In the current review, we aim (1) to provide a summary of NTP bioassays with treatment-associated effects involving MNCL and LCTs in addition to male F344-specific tunica vaginalis mesothelioma (TVM); (2) to describe important pathobiological differences between these F344 rat tumor responses and similar target tissue-tumor response in humans; and (3) to present the NTP reasons for switching away from the F344 rat. We show that due to the highly variable background incidence of F344 MNCL, more reliance on historical control data than is usual for most tumor responses is warranted to evaluate potential effect of any chemical treatment in this rat strain. The high spontaneous incidence of LCTs in the testes of male F344 rats has made this tumor endpoint of little practical use in identifying potential testicular carcinogenic responses. TVM responses in F344 rats have a biological plausible relationship to LCTs unlike TVM in humans. Given their high spontaneous background incidence and species-specific biology, we contend that MNCL and LCT, along with TVM responses, in F344 rat carcinogenicity studies are inappropriate tumor types for human health risk assessment and lack relevance in predicting human carcinogenicity.

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Malignant Mesothelioma of the Tunica Vaginalis Testis

Cited by 21 publications

References 38 publications

Clinical Features and Outcomes of Tunica Vaginalis Mesothelioma: A Case Series From the National Institutes of Health

Clinical Features and Outcomes of Tunica Vaginalis Mesothelioma: A Case Series From the National Institutes of Health

Malignant mesothelioma of the tunica vaginalis testis: a malignancy associated with recurrent epididymitis?

The legacy of the F344 rat as a cancer bioassay model (a retrospective summary of three common F344 rat neoplasms)

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