Malignant mesenchymal tumor with leiomyosarcoma, rhabdomyosarcoma, chondrosarcoma, and osteosarcoma differentiation: case report and literature review

Li, Yao‐Feng; Yu, Cheng; Wu, Seng-Tang; Dai, Ming‐Shen; Lee, Herng‐Sheng

doi:10.1186/1746-1596-6-35

Cited by 12 publications

(15 citation statements)

References 21 publications

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“…Although leiomyosarcoma has also been described elsewhere in the pelvis including the cervix [17] and urinary bladder [18], it is more commonly found in the uterus. ULMS have high metastatic potential and 5 year survival rates vary from 0% to 73% in the literature [19-21].…”

Section: Discussionmentioning

confidence: 99%

Isolated cutaneous metastasis of uterine leiomyosarcoma: case report and review of literature

et al. 2012

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A 54 year old lady presented for routine excision of a scalp lesion thought clinically to represent a sebaceous cyst of the right occiput. 4 years earlier she underwent total abdominal hysterectomy and right salpingo-oophorectomy for 3 large uterine fibroids. Histo-pathological examination of the hysterectomy specimen revealed an incidental low-grade leiomyosarcoma. Staging imaging was negative for metastatic disease. She made an uneventful recovery and was treated further by adjuvant pelvic radiotherapy.She noticed an uncomfortable and unsightly cystic swelling on her occiput four years after hysterectomy and was referred for routine excision of what was believed to be a benign lesion. The lesion was excised and sent for histopathological examination. Microscopic analysis including immuno-histochemistry demonstrated an ER and PR positive metastatic deposit of leiomyosarcoma. The margins of excision were histologically clear of disease.At Multi-Disciplinary Team (MDT) discussion a diagnosis of metastatic scalp deposit from previous uterine leiomyosarcoma was made. Re-staging CT brain, thorax, abdomen and pelvis and MRI brain were negative for local recurrence or distant metastases. She is currently undergoing radiotherapy to the scalp and surrounding tissues and will be followed up closely by the involved teams.To the best of our knowledge, this is the first case described in the worldwide literature of isolated cutaneous metastasis to the scalp of uterine leiomyosarcoma without evidence of disseminated disease at other sites.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1311834987345566.

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Section: Discussionmentioning

confidence: 99%

Isolated cutaneous metastasis of uterine leiomyosarcoma: case report and review of literature

et al. 2012

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“…Both of these features may be used to differentiate adamantinoma from GCAB [11]. Some of the malignant mesenchymomas, including leiomyosarcoma, rhabdomyosarcoma, chondrosarcoma, osteosarcoma and myxomatous components, should also be considered as differential diagnoses [12], and are distinguishable from GCAB by its lack of malignancy.…”

Section: Differential Diagnosis and Prognosismentioning

confidence: 99%

Clinical and pathological characteristics of giant cell angioblastoma: a case report

et al. 2012

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Giant cell angioblastoma (GCAB) is an extremely rare soft tissue tumor of early childhood and only five cases have been described to date. As such the clinical, pathological, and prognostic features are poorly defined. We prensent here a new case of GCAB in bone of a child aged 4-years old. The lesion was composed of dense and loose cell regions. The dense regions were characterized by nodular, linear, and plexiform aggregates of oval- to spindle-shaped tumor cells around small vascular channels and interspersed with large mononuclear cells and multinucleate giant cells. The loose cell areas were characterized by distributed fibroblasts and abundant myxoid matrix, which diminished with patient age. Infiltrative growth was observed in some areas. Oval-to-spindle cells showed positivity for Vimentin, CD31 and CD34 staining, and partial positivity for smooth muscle actin. Mononuclear cells and multinucleate giant cells showed Vimentin and CD68 positivity. Seventeen months after thorough curettage of the lesion, a local recurrence was found. Based upon the clinical, histological and immunohistochemical findings, infiltrate condition, and prognosis, we classified GCAB into two subtypes. Type I does not infiltrate surrounding tissues and has good prognosis. Type II infiltrates the surrounding tissues, relapses earlier, and has worse prognosis. This report augments the limited GCAB literature to promote our understanding and guide therapy of this rare disease.Virtual slidesThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/6699811297488137

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“…Focal keratin positivity is comon in anaplastic carcinomas. Immunohistochemically, leiomyosarcomas are reactive for desmin or vimentin and actin [9]. In our patient, the diagnosis of leiomyosarcoma was favored because smooth muscle markers and desmin were positive and immunostains for keratins were negative.…”

Section: Discussionmentioning

confidence: 77%

Primary leiomyosarcoma of the thyroid

Ege¹,

Leventoğlu

2013

J Korean Surg Soc

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Malignant mesenchymal tumor with leiomyosarcoma, rhabdomyosarcoma, chondrosarcoma, and osteosarcoma differentiation: case report and literature review

Cited by 12 publications

References 21 publications

Isolated cutaneous metastasis of uterine leiomyosarcoma: case report and review of literature

Isolated cutaneous metastasis of uterine leiomyosarcoma: case report and review of literature

Clinical and pathological characteristics of giant cell angioblastoma: a case report

Primary leiomyosarcoma of the thyroid

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