Malignant Meningioma with Cartilage and Giant Cells

Abstract

An autopsy case of recurrent and malignant meningioma is reported. This case was originally typical benign transitional meningioma of the falx, however, the histology of the tumor changed to show malignant features during successive recurrences. At autopsy, the tumor revealed findings consistent with malignant meningioma. One of the most interesting features was the presence of cartilage and giant cells in some parts. Immunohistochemistry showed positive immunoreactivity for S‐100 protein in some cartilage and giant cells and for cytokeratin in some giant cells. Multi‐differential potential of the meningioma cells was suggested in this case.