Malignant melanoma transformation within a nevus of Ito

Wise, Sean R; Capra, Gregory; Martin, Peter; Wallace, Donna; Miller, Charles H.

doi:10.1016/j.jaad.2009.09.003

Cited by 26 publications

(21 citation statements)

References 20 publications

(31 reference statements)

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“…Also the physician will be more vigilant while dealing with either of the nevi as far as the prognosis and management strategy is concerned as malignant transformation may rarely occur in both the nevi. [28]…”

Section: Discussionmentioning

confidence: 99%

Unilateral nevus of ota with bilateral nevus of Ito and palatal lesion: A case report with a proposed clinical modification of tanino′s classification

Mukhopadhyay¹

2013

Indian J Dermatol

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Nevus of Ota and nevus of Ito are rare dermal melanocytoses. Nevus of Ota may be very rarely associated with the nevus of Ito and other extra cutaneous features. Both nevi are similar in all respect apart from the area of distribution. Bilateral distribution of nevus of Ito is seldom reported in the literature. A 24-year-old male patient reported with nevus of Ota of the right side of his face since his infancy and nevus of Ito on both shoulder regions since early childhood. He had bluish lesions on the right side of his hard palate. Systemic examination was normal. Relevant laboratory investigations were non contributory. The histopathological examination of the skin from the affected areas showed the presence of elongated dendritic dermal melanocytes. The present case is the first report of an association of bilateral nevus of Ito with nevus of Ota and palatal lesions. Tanino classified Nevus of Ota into four groups. As both the nevi are similar in all respect except the area of distribution, a minor modification of the existing Tanino's classification to incorporate the nevus of Ito into the classification for the Ota's nevus may be appropriate.

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Section: Discussionmentioning

confidence: 99%

Unilateral nevus of ota with bilateral nevus of Ito and palatal lesion: A case report with a proposed clinical modification of tanino′s classification

Mukhopadhyay¹

2013

Indian J Dermatol

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“…All dermal melanocytosis are generally considered benign, although rare cases of malignant transformation have been described in literature 6. Although nevus of Ito is much more prevalent in Asian populations, it is generally recognised that the risk of malignant transformation appears to be much more common in Caucasian individuals 3 6.…”

Section: Discussionmentioning

confidence: 99%

“…Although nevus of Ito is much more prevalent in Asian populations, it is generally recognised that the risk of malignant transformation appears to be much more common in Caucasian individuals 3 6. Consequently, vigilance may be necessary, particularly, when these lesions occur in Caucasian individuals 6. Skin biopsies after the diagnosis are necessary only if clinical changes or malignant transformation are suspected within the involved skin, ocular or mucosal tissues 8…”

Section: Discussionmentioning

confidence: 99%

“…These lesions are typically associated with Asians, but can also appear in Caucasians patients 4 5. Because of their similar histology, differentiating dermal melanocytic lesions is most often supported on clinical features and anatomic distribution 1 6…”

Section: Introductionmentioning

confidence: 99%

“…The Mongolian spot, nevi of Ota and Ito are the most common morphological forms of dermal melanocytosis 6. Nevus of Ito is often unilateral and clinically similar to nevus of Ota,6 except in anatomic location, which corresponds to the distribution of the posterior supraclavicular and cutaneous brachial nerves 6 7…”

Section: Introductionmentioning

confidence: 99%

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Late onset Ito's nevus

et al. 2013

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SUMMARYDermal melanocytoses include a variety of congenital and acquired melanocytic lesions characterised by the presence of multiple spindle-shaped dendritic melanocytes in the dermis. These lesions are commonly found in the skin of Asians, but they can also appear in Caucasians. The Mongolian spot, nevi of Ota and Ito are the most common morphological forms. We report a case of a 24-year-old Caucasian woman presented with a 10-months history of progressive darkening of the right side of her upper back. Cutaneous examination revealed a macular blue-grey hyperpigmentation of the right side of her upper back. Biopsy specimen from the macule showed multiple darkly pigmented, spindle-shaped dendritic melanocytes in the superficial dermis, interstitially arranged between collagen bundles. The diagnosis of nevus of Ito was established. Our patient is maintaining vigilance in dermatology consultation. BACKGROUND

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Benign Melanocytic Proliferations and Melanocytic Naevi

Stefanaki

Antoniou

Stratigos

2016

Rook's Textbook of Dermatology, Ninth Edition

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Benign cutaneous melanocytic proliferations are the most common neoplasms occurring in humans. Although benign in nature, they are often problematic for the patient due to aesthetic concerns or their association with other medical conditions. For dermatologists, melanocytic lesions are generally considered risk factors, precursors or simulants of melanoma, posing significant diagnostic and management issues in clinical practice. This chapter describes the spectrum of benign melanocytic lesions, their divergent clinical varieties and underlying pathogenetic pathways, their histological features, their association with other diseases – particularly melanoma – and their current principles of treatment.

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Malignant melanoma transformation within a nevus of Ito

Cited by 26 publications

References 20 publications

Unilateral nevus of ota with bilateral nevus of Ito and palatal lesion: A case report with a proposed clinical modification of tanino′s classification

Unilateral nevus of ota with bilateral nevus of Ito and palatal lesion: A case report with a proposed clinical modification of tanino′s classification

Late onset Ito's nevus

Benign Melanocytic Proliferations and Melanocytic Naevi

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