Malignant melanoma presenting as multiple discharging sinuses

Bhagwat, Pradeep Vittal; Kudligi, Chandramohan; S, Bm; Thirunavukkarasu, Arun; Me, Rao Shendre; Ss, Giriyan

doi:10.4103/0019-5154.62742

Cited by 3 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…KRT13 is a keratin family protein that pairs with KRT4 47 and co-localizes in the non-cornified stratified epithelia. 48 Consistent with the expression pattern of KRT13 , KRT4 also exhibited a ‘Temporary Peak’ pattern 10 days of post-delivery ( Fig. 3B ).…”

Section: Resultssupporting

confidence: 80%

Comprehensive analysis of 124 transcriptomes from 31 tissues in developing, juvenile, and adult Japanese Black cattle

Arishima¹,

Wakaguri

Nakashima³

et al. 2022

DNA Research

View full text Add to dashboard Cite

Omic analyses of economically important animals, including Japanese Black cattle, are currently underway worldwide. In particular, tissue-and developmental stage-specific transcriptome characterization is essential for understanding the molecular mechanisms underlying the phenotypic expression of genetic disorders and economic traits. Here, we conducted a comprehensive analysis of 124 transcriptomes across 31 major tissues from fetuses, juvenile calves, and adult Japanese Black cattle using short-read sequencing. We found that genes exhibiting high tissue-specific expression tended to increase after 60 days from fertilization and significantly reflected tissue-relevant biology. Based on gene expression variation and inflection points during development, we categorized gene expression patterns as stable, increased, decreased, temporary, or complex in each tissue. We also analyzed the expression profiles of causative genes (e.g., SLC12A1, ANXA10, and MYH6) for genetic disorders in cattle, revealing disease-relevant expression patterns. Additionally, to directly analyze the structure of full-length transcripts without transcript reconstruction, we performed RNA sequencing (RNA-seq) analysis of 22 tissues using long-read sequencing and identified 232 novel non-RefSeq isoforms. Collectively, our comprehensive transcriptomic analysis can serve as an important resource for the biological and functional interpretation of gene expression and enable the mechanistic interpretation of genetic disorders and economic traits in Japanese Black cattle.

show abstract

Section: Resultssupporting

confidence: 80%

Comprehensive analysis of 124 transcriptomes from 31 tissues in developing, juvenile, and adult Japanese Black cattle

Arishima¹,

Wakaguri

Nakashima³

et al. 2022

DNA Research

View full text Add to dashboard Cite

show abstract

“…Another case of primary skin cancer, a malignant melanoma, has been reported to present as multiple discharging sinuses, that too from India. [ 63 ] Other rare variants of SCC are the adenoid, pseudovascular, clear cell, “signet ring”, pigmented, inflammatory, basaloid, infiltrative, desmoplastic and rhabdoid types.…”

Section: Clinical Aspectsmentioning

confidence: 99%

Nonmelanoma skin cancer in India: Current scenario

Panda

2010

Indian J Dermatol

View full text Add to dashboard Cite

Incidence of skin cancers has been increasing since the last few decades worldwide. Nonmelanoma skin cancer (NMSC) is the commonest variety of cutaneous malignancy. Conventional wisdom has it that the incidence of all varieties of skin cancers is lower among Indians due to the protective effects of melanin. Though national surveys and cross-country data in India are unavailable, there are indirect indications from several smaller reports that NMSCs may be on the rise in India. Reports of quite a few atypical cases lead us to hypothesize that factors other than ultraviolet radiation may be important in the occurrences of these cancers, particularly in the skin types prevalent in India. The descriptive epidemiology and clinical characteristics of squamous and basal cell carcinoma in India, including their variants, are discussed here along with hypotheses on their etiopathogenesis. Novel management techniques currently available in India are also highlighted.

show abstract

“…Other malignancies such as non‐Hodgkin lymphoma 2 and inflammatory disorders such as histiocytosis‐X 3 can also present as discharging sinuses. Other case reports of malignancies on the skin presenting with sinuses include sarcomatoid SCC, thyroid carcinoma and malignant melanoma 4–6 . SCC can usually be confirmed easily by biopsy, but in our case the first two biopsies showed only nonspecific infiltrate, and a third biopsy was required to confirm the diagnosis.…”

Section: Reportmentioning

confidence: 61%

Squamous cell carcinoma presenting as multiple discharging sinuses on the chin

Pahwa¹,

Sharma²,

Chouhan³

et al. 2011

Clinical and Experimental Dermatology

View full text Add to dashboard Cite

Squamous cell carcinoma (SCC) usually presents as a raised, firm, pink to skin-coloured keratotic papule, plaque or ulcer, arising on sun-exposed skin. We report an unusual case of a 65-year-old male patient who presented with a 1-year history of multiple discharging sinuses on his chin, which on investigation was found to be an SCC. A malignancy should be considered in the differential diagnoses of patients presenting with multiple discharging sinuses on the chin. We discuss other possible diagnoses for sinuses presenting on the face.

show abstract

Malignant melanoma presenting as multiple discharging sinuses

Cited by 3 publications

References 4 publications

Comprehensive analysis of 124 transcriptomes from 31 tissues in developing, juvenile, and adult Japanese Black cattle

Comprehensive analysis of 124 transcriptomes from 31 tissues in developing, juvenile, and adult Japanese Black cattle

Nonmelanoma skin cancer in India: Current scenario

Squamous cell carcinoma presenting as multiple discharging sinuses on the chin

Contact Info

Product

Resources

About