Malignant Melanoma in Infancy

Lyall, David

doi:10.1001/jama.1967.03130260075024

Cited by 59 publications

(23 citation statements)

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“…This finding was concordant with most previous literature. Of note, no "invasive" melanoma had been reported in childhood LM [20,21], but only a few cases of melanoma "in situ" had been reported [8][9][10][11]. The presence of worrisome clinical features, such as the Hutchinson sign or a band width of more than 3 mm, was not pathognomonic of melanoma.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Melanonychia: Differences in Etiology Are Associated with Patient Age at Diagnosis

Tseng¹,

Liang²,

Liau³

et al. 2017

Dermatology

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Background: Longitudinal melanonychia (LM) may occur as a result of nail apparatus melanoma. Knowledge of etiology plays an important role in the management of LM. Objectives: The study is aimed to compare the diagnosis of LM in different age groups. Methods: We collected 63 cases (45 adults and 18 children) with LM who underwent nail matrix biopsy or excision in a 21-year cohort and assessed their clinicopathological features. Results: Melanomas in adults and children were 40% and none, while nevi accounted for 15.6% in adults and 94.4% in children. There was a statistically significant difference between the average age at diagnosis for melanoma (54.5 ± 13.3 years) and nevus (15.2 ± 18.5 years). Logistic regression related the occurrence of melanoma to older ages with a relative risk of 1.2 compared to nevus, but no cutoffs between age groups could be deﬁned between LM-associated nevus and melanoma. Conclusion: The adult group has a significantly higher risk of melanoma, while children with LM show mostly nonmelanoma etiologies. Tissue proof is more warranted in adult cases, and it is needed in selected cases of children with LM.

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Section: Discussionmentioning

confidence: 99%

Longitudinal Melanonychia: Differences in Etiology Are Associated with Patient Age at Diagnosis

Tseng¹,

Liang²,

Liau³

et al. 2017

Dermatology

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“…In an extensive lit erature search only 1 case was found. Lyall [19] reported a malignant melanoma which developed at a pigmented spot on the tip of the right middle fingernail in a 12-month-old boy. Therefore, malignant melanoma in the nail area in children is extremely rare.…”

Section: Discussionmentioning

confidence: 99%

Regressing Nevoid Nail Melanosis in Childhood

Kikuchi¹,

Inoue

Sakaguchi

et al. 1993

Dermatology

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The natural course of nail pigmentation was documented in 4 Japanese children. Although initial progression of melanosis concerning size and degree of pigmentation was noted, all cases showed a tendency to fade during the follow-up period. The published cases of nevoid nail melanosis in childhood were reviewed, and we concluded that they were essentially benign. However, should there be any suspicion of malignant changes, punch biopsy is indicated for medico-legal reasons. Management of growing pigmented nail streaks in childhood is one of the most difficult and delicate problems facing dermatologists, as they can be precursors of malignant melanoma. There is a condition of the nail known as longitudinal melanonychia or naevus striae unguis, possibly of nevoid nature. Prevalence rates of nevoid diseases showing pigmentation of the skin vary depending on the ethnic origin. In order to understand the natural course of nail area pigmentation in childhood, we have followed 4 Japanese children with such a condition. We report our observations and review the literature.

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“…Nail matrix nevi are typically seen in childhood, and they may be congenital or acquired. Nail melanoma in children is extremely rare [25,26,27]. Clinical and dermoscopic parameters used in adults are not valid for children [28].…”

Section: Alterations Of the Nail Platementioning

confidence: 99%

Dermoscopy in the Evaluation of Nail Disorders

Alessandrini

Starace

Piraccini³

2017

Skin Appendage Disord

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Nail dermoscopy was initially used only in the assessment of nail pigmentation, but now it is widely utilized for the evaluation of many nail disorders. In daily practice, dermoscopy may confirm clinical diagnoses and guides in the management of nail diseases and treatments, permitting a better visualization of symptoms. Dry dermoscopy is required for evaluation of the nail plate surface, while gel as an interface is necessary for assessment of nail pigmentation and onycholysis, as well as for the evaluation of the distal nail margin. In this review, we describe the dermoscopic features of the most important nail disorders, looking at the different areas of the nail. Dermatoscopic changes that usually accompany specific nail diseases are also reviewed.

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Malignant Melanoma in Infancy

Cited by 59 publications

References 0 publications

Longitudinal Melanonychia: Differences in Etiology Are Associated with Patient Age at Diagnosis

Longitudinal Melanonychia: Differences in Etiology Are Associated with Patient Age at Diagnosis

Regressing Nevoid Nail Melanosis in Childhood

Dermoscopy in the Evaluation of Nail Disorders

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