Regressing Nevoid Nail Melanosis in Childhood

Kikuchi, Ichiro; Inoue, Shuhei; Sakaguchi, Ei; Ono, Tomomichi

doi:10.1159/000247314

Cited by 55 publications

(33 citation statements)

References 10 publications

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“…This finding was concordant with most previous literature. Of note, no "invasive" melanoma had been reported in childhood LM [20,21], but only a few cases of melanoma "in situ" had been reported [8][9][10][11]. The presence of worrisome clinical features, such as the Hutchinson sign or a band width of more than 3 mm, was not pathognomonic of melanoma.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Melanonychia: Differences in Etiology Are Associated with Patient Age at Diagnosis

Tseng¹,

Liang²,

Liau³

et al. 2017

Dermatology

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Background: Longitudinal melanonychia (LM) may occur as a result of nail apparatus melanoma. Knowledge of etiology plays an important role in the management of LM. Objectives: The study is aimed to compare the diagnosis of LM in different age groups. Methods: We collected 63 cases (45 adults and 18 children) with LM who underwent nail matrix biopsy or excision in a 21-year cohort and assessed their clinicopathological features. Results: Melanomas in adults and children were 40% and none, while nevi accounted for 15.6% in adults and 94.4% in children. There was a statistically significant difference between the average age at diagnosis for melanoma (54.5 ± 13.3 years) and nevus (15.2 ± 18.5 years). Logistic regression related the occurrence of melanoma to older ages with a relative risk of 1.2 compared to nevus, but no cutoffs between age groups could be deﬁned between LM-associated nevus and melanoma. Conclusion: The adult group has a significantly higher risk of melanoma, while children with LM show mostly nonmelanoma etiologies. Tissue proof is more warranted in adult cases, and it is needed in selected cases of children with LM.

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Section: Discussionmentioning

confidence: 99%

Longitudinal Melanonychia: Differences in Etiology Are Associated with Patient Age at Diagnosis

Tseng¹,

Liang²,

Liau³

et al. 2017

Dermatology

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“…Fading of melanonychia accompanies the disappearance of the dots. These dots are then a sign of regression of a nevus and not a warning sign of a melanoma [29]. Dermoscopic patterns that may suggest a melanoma in children are the rapid evolution of a brown background with longitudinal brown-to-black lines with an irregular color, spacing, and thickness and ending abruptly.…”

Section: Alterations Of the Nail Platementioning

confidence: 99%

Dermoscopy in the Evaluation of Nail Disorders

Alessandrini

Starace

Piraccini³

2017

Skin Appendage Disord

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Nail dermoscopy was initially used only in the assessment of nail pigmentation, but now it is widely utilized for the evaluation of many nail disorders. In daily practice, dermoscopy may confirm clinical diagnoses and guides in the management of nail diseases and treatments, permitting a better visualization of symptoms. Dry dermoscopy is required for evaluation of the nail plate surface, while gel as an interface is necessary for assessment of nail pigmentation and onycholysis, as well as for the evaluation of the distal nail margin. In this review, we describe the dermoscopic features of the most important nail disorders, looking at the different areas of the nail. Dermatoscopic changes that usually accompany specific nail diseases are also reviewed.

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“…Although Hutchinson's sign is not necessarily characteristic of subungual malignant melanoma but can be also seen in melanocytic nevi, it is useful as an early clinical sign of subungual malignant melanoma because it is believed to be present from the earliest stage (16) and, as Hutchinson properly said in his report of melanotic whitlow in 1886 (17), "it is, from the beginning, malignant." Some authors strongly propose that melanonychia in children be left untouched even if they are atypical in appearance, because they frequently disappeared clinically (18). Nevertheless, clinical loss of visibility does not always mean actual disappearance of the lesion.…”

Section: Discussionmentioning

confidence: 99%

Malignant Melanoma In situ Arising in the Nail Unit of a Child

Kiryu

1998

The Journal of Dermatology

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A very rare case of malignant melanoma in situ of the nail unit of a child is presented. Clinically, a pigmented streak was present on the finger nail of a 3-year-old girl, and the lesion increased in size and in darkness of the color associated with periungual pigmentation in the following two years. Histopathologically, sections showed proliferation of atypical melanocytes, arranged mostly in single units but some in nests, in and above the basal layer of the epithelium and admixed with long dendrites and a few mitotic figures. Pigmented lesions of nail units of children often show fading or loss of pigmentation clinically; however, a biopsy should be done when they show augmentative changes which clinically suggest malignancy, because subungual malignant melanoma can exist even in children, and proper biopsy can detect it in its early stages.

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Regressing Nevoid Nail Melanosis in Childhood

Cited by 55 publications

References 10 publications

Longitudinal Melanonychia: Differences in Etiology Are Associated with Patient Age at Diagnosis

Longitudinal Melanonychia: Differences in Etiology Are Associated with Patient Age at Diagnosis

Dermoscopy in the Evaluation of Nail Disorders

Malignant Melanoma In situ Arising in the Nail Unit of a Child

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